Antitumorigenic effect of damnacanthal on melanoma cell viability through p53 and NF‑κB/caspase‑3 signaling pathways

Zhang, Xin; Fang, Ping; Zhao, Zhiyun; Ding, Xiangyu; Xie, Fang; Wang, Yilin; Li, Chang-Jiu

doi:10.3892/ol.2018.9379

Cited by 2 publications

(1 citation statement)

References 22 publications

(27 reference statements)

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“…IFN-α/β signaling affects the p53 responses in tumor suppression and antiviral defense (43). The sensitization effect of IFN-β in TMZ-treated melanoma cells is dependent on p53 (15), in which p21 is directly activated (44). In addition to growth inhibition, G 2 /M cell cycle arrest as a result of p21 activation following treatment with TMZ plus IFN-β was observed in the present study.…”

Section: Discussionsupporting

confidence: 66%

Interferon-β sensitizes human malignant melanoma cells to temozolomide-induced apoptosis and autophagy

et al. 2019

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Malignant melanoma is a highly aggressive skin cancer that is highly resistant to chemotherapy. Adjuvant therapy is administered to patients with melanoma that possess no microscopic metastases or have a high risk of developing microscopic metastases. Methylating agents, including dacarbazine (DTIC) and temozolomide (TMZ), pegylated interferon (IFN)-α2b and interleukin-2 have been approved for adjuvant immuno-chemotherapy; however, unsatisfactory results have been reported following the administration of methylating agents. IFN-β has been considered to be a signaling molecule with an important therapeutic potential in cancer. The aim of the present study was to elucidate whether antitumor effects could be augmented by the combination of TMZ and IFN-β in malignant melanoma. We evaluated the efficacy of TMZ and IFN-β by comparing O 6-methylguanine-DNA transferase (MGMT)-proficient and-deficient cells, as MGMT has been reported to be associated with the resistance to methylating agents. Cell viability was determined by counting living cells with a Coulter counter, and apoptosis was analyzed by dual staining with Annexin V Alexa Fluor ® 488 and propidium iodide. The expression of proteins involved in the cell cycle, apoptosis and autophagy was evaluated by western blot analysis. The combined treatment with TMZ and IFN-β suppressed cell proliferation and induced cell cycle arrest. We also demonstrated that a combination of TMZ and IFN-β enhanced apoptosis and autophagy more efficiently compared with TMZ treatment alone. These findings suggest that antitumor activity may be potentiated by IFN-β in combination with TMZ.

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Section: Discussionsupporting

confidence: 66%

Interferon-β sensitizes human malignant melanoma cells to temozolomide-induced apoptosis and autophagy

et al. 2019

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Efficacy and Safety of Morinda citrifolia L. (Noni) as a Potential Anticancer Agent

et al. 2022

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Cancer is a major cause of morbidity and mortality worldwide and therefore there has been interest in discovering the phytoconstituents of medicinal plants exhibiting anticancer activities. Morinda citrifolia L., commonly known as Noni, has shown anticancer properties in in vitro, in vivo, and in clinical studies. A systematic review was conducted to collate scientific evidence on the anticancer properties of M. citrifolia using pre-determined keywords on 5 electronic databases: MEDLINE, CENTRAL, LILACS, Web of Science, and EBSCOHost. A total of 51 clinical and preclinical studies comprising 41 efficacy and 10 safety studies were included in this review. Our findings showed that M. citrifolia demonstrated various anticancer properties in different cancer models, via multiple mechanisms including antitumor, antiproliferative, pro-apoptotic, antiangiogenesis, antimigratory, anti-inflammatory, and immunomodulatory activities. M. citrifolia is deemed to be a potentially valuable medicinal plant in the treatment of cancer through its many intrinsic pathways. More well-designed and reported preclinical efficacy and safety studies are needed to allow for better translation into future clinical studies which could further substantiate the role of M. citriflolia in cancer treatment.

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Antitumorigenic effect of damnacanthal on melanoma cell viability through p53 and NF‑κB/caspase‑3 signaling pathways

Cited by 2 publications

References 22 publications

Interferon-β sensitizes human malignant melanoma cells to temozolomide-induced apoptosis and autophagy

Interferon-β sensitizes human malignant melanoma cells to temozolomide-induced apoptosis and autophagy

Efficacy and Safety of Morinda citrifolia L. (Noni) as a Potential Anticancer Agent

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