Antitumour polycyclic acridines. Part 5.1 Synthesis of 7H-pyrido[4,3,2-kl ]acridines with exploitable functionality in the pyridine ring

Cyanoacetylation of 5-Aminopyrazole: Synthesis of 2-(1-Aryl-4- substituted pyrazolo[3,4-d]pyrimidin-6-yl)acetonitrile Derivatives

“…Pyrazolopyrimidines and related fused heterocycles are of interest as potential bioactive molecules. They are known to function as CNS (Central Nervous System) depressants [1], neuroleptic agents [2], and tuberculostatic agents [3]. Pyrazolo [3,4-d]pyrimidines were identified as a general class of adenosine receptors [4,5].…”

Synthesis of novel pyrazolopyridine and pyridopyrimidine derivatives

“…Pyridobenzodiazepine derivatives [1][2][3], pyrazolopyridine, and related fused heterocycles are of interest as potential bioactive molecules. They are known to exhibit pharmacological activities such as CNS depressant [4,5], neuroleptic [6], and turberculostatic [7]. Pyrazolo [3,4-b] pyridines were reported as antimicrobial agents [8], inhibitors of glycogen synthesis kinase-3(GSK-3) [9], and potent antitumor agents [10].…”

Anti-Hepatitis B Virus Activity of New N4-β-D-Glycoside Pyrazolo[3,4-d]pyrimidine Derivatives

“…Pyrazolopyrimidines and related fused heterocycles are of interest as potential bioactive molecules. They are known to exhibit pharmacological activities such as CNS-depressant (Abdou et al, 2004;Julino and Stevens, 1998), antiviral (Gadhachanda et al, 2007) anticancer (Capdeville et al, 2002;Taylor et al, 1992;Al-Saadi et al, 2008) and tuberculostatic (Ghorab et al, 2004) activities. Pyrazolo [3,4-d]pyrimidines were identifi ed as a general class of adenosine receptors (Davies et al, 1983(Davies et al, , 1984.…”