Antitussive Effect of Herbal Medicine Bakumondo-to: A Case Report

Mizushima, Yutaka; Hirata, Atsushi; Hori, Tooru; Sawazaki, Shigeki; Sugiyama, Eiji; Kobayashi, Masashi

doi:10.1142/s0192415x96000384

Cited by 4 publications

(2 citation statements)

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“…Interestingly, ophiopogonin-D, an active constituent of bakumondo-to, a Chinese herbal medicine, hyperpolarized the membrane potential via activation of the K + current, reducing the cell excitability of PTG neurons [52]. Bakumondo-to is found to be effective for treating clinically chronic coughs [53,54], and to inhibit codeine-registrant coughs as that expressed in the experimental model described above [55,56]. Therefore, we speculate that the excitability of PTG neurons may contribute to pathological condition, including some kinds of chronic cough.…”

Section: Peripheral Opioid Receptors and Antitussive Effectsmentioning

confidence: 99%

Central and peripheral mechanisms of narcotic antitussives: codeine-sensitive and -resistant coughs

Takahama

Shirasaki

2007

Cough

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Narcotic antitussives such as codeine reveal the antitussive effect primarily via the µ-opioid receptor in the central nervous system (CNS). The κ-opioid receptor also seems to contribute partly to the production of the antitussive effect of the drugs. There is controversy as to whether δ-receptors are involved in promoting an antitussive effect. Peripheral opioid receptors seem to have certain limited roles. Although narcotic antitussives are the most potent antitussives at present, certain types of coughs, such as chronic cough, are particularly difficult to suppress even with codeine. In guinea pigs, coughs elicited by mechanical stimulation of the bifurcation of the trachea were not able to be suppressed by codeine. In gupigs with sub-acute bronchitis caused by SO 2 gas exposure, coughing is difficult to inhibit with centrally acting antitussives such as codeine. Some studies suggest that neurokinins are involved in the development of codeine-resistant coughs. However, evidence supporting this claim is still insufficient. It is very important to characterize opiate-resistant coughs in experimental animals, and to determine which experimentally induced coughs correspond to which types of cough in humans. In this review, we describe the mechanisms of antitussive effects of narcotic antitussives, addressing codeine-sensitive and -resistant coughs, and including our own results.

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Section: Peripheral Opioid Receptors and Antitussive Effectsmentioning

confidence: 99%

Central and peripheral mechanisms of narcotic antitussives: codeine-sensitive and -resistant coughs

Takahama

Shirasaki

2007

Cough

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“…Bakumondo‐to (Maimendong tang), a Chinese herbal medicine which has been used as an anti‐tussive agent, 4–7 was recently proved to exert several pharmacological effects, including attenuating neurogenic inflammation. However, there are no controlled clinical trials nor observation in regard to the effects of Bakumondo‐to on experimental airway inflammation and hyperresponsiveness.…”

Section: Introductionmentioning

confidence: 99%