Antityphoid properties and toxicity evaluation of Harungana madagascariensis Lam (Hypericaceae) aqueous leaf extract

Kengni, Fabrice; Fodouop, Siméon P. C.; Tala, Donald Sédric; Djimeli, Merline Namekong; Fokunang, Charles; Gatsing, Donatien

doi:10.1016/j.jep.2015.12.037

Cited by 26 publications

(20 citation statements)

References 24 publications

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“…Influenza, pneumonia, wounds, family planning, typhoid, over bleeding during menstruation cycle and birth [105] Antibacterial and antifungal activities (petroleum ether and aqueous leaf extracts) [109], antifungal activity (The methanol leaf extract) [110] in vitro (Agar well and disc diffusion assays) [109], in vitro (Agar well diffusion technique) [110] The LC 50 was reported to be < 250 µg/ mL in the brine shrimp lethality assay [111] Croton dichogamous Pax Chest congestion (wheezing) [112] Polio like-symptoms, gonorrhea, chest pains [39] Threatened abortion, infertility [113] Pesticidal activity [114] No [115] In vitro (Broth dilution technique) [116], in vitro (Solid dilution method, bioautography) [117] The aqueous leaf extract was reported to induce liver damage at high doses of > 100 mg/kg and > 200 mg/kg in female and male rats respectively [118].…”

Section: Diversity Of Medicinal Plants Identified In the Study Area Amentioning

confidence: 99%

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

et al. 2020

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Background: Poor access to healthcare in rural communities causes many people to seek herbalists who use medicinal plants for the treatment of various disease conditions. Most knowledge of traditional herbal medicine makes use of indigenous remedies which are often undocumented and are at risk of being lost. The preservation of this knowledge may facilitate scientific inquiry into promising new therapeutic molecules. Methods: Semi-structured questionnaires were used to collect the sociodemographic information of 30 herbalists in Kisumu East Sub County. The local names of medicinal plants used in managing illnesses of the respiratory system, their habit, active parts, indications, methods of preparation, routes of administration, scientific identity, and conservation status were also recorded. Other reported traditional uses, pharmacological activities, and toxicological data were identified via a literature search. Results: Most herbalists were female (86.7%), aged between 61 and 70 years (43.3%) with no formal education (56.7%), and had 21-30 years of practice (30%). 44 plant species, belonging to 43 genera and 28 families were identified. Leguminosae and Rutaceae plant families were predominant, leaves were frequently used (33%), and trees were the most common habit (44.4%). Most plants were collected in the wild (79.2%), preparation was mainly by decoction (68.8%), and the administration was mainly orally. The main indication was cough and 79.5% of all documented plant species had previously been reported to have a pharmacological activity relevant to the mitigation of respiratory illnesses. Toxicological data was available for 84.1% of the plant species identified. Conclusions: The predominant use of roots, root barks, and root tubers by herbalists in Kisumu East Sub County threatens to negatively impact the ecological survival of some plant species. The preservation of herbalists' knowledge of medicinal plants in the study area is a pressing concern considering their advanced age and little formal education. There is a need to conserve some of the medicinal plants documented in this study. The medicinal claims made by herbalists also warrant scientific scrutiny.

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Section: Diversity Of Medicinal Plants Identified In the Study Area Amentioning

confidence: 99%

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

et al. 2020

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“…The results revealed an oral LD 50 of 3000 mg/kg Acute toxicity: LD 50 of aqueous leaf extract were 11.6 g/kg and 13.2 g/kg bw for female and male mice respectively (Kengni et al, 2013) Subacute toxicity: 25, 50, 100, 200 mg/kg bw of the aqueous leaf extract were administrated orally to rats for 14 days. the extract induced hypercholesterolaemia and liver damage at high doses (Kengni et al, 2016) Polyphenols, tannins, and triterpenes. Alkaloids, saponins, and flavonoids (Tjeck et al, 2017) Irvingiaceae: Irvingia gabonensis (Aubry-Lecomte ex O'Rorke) Baill.…”

Section: Mammea Africana Sabinementioning

confidence: 93%

An overview of anti-diabetic plants used in Gabon: Pharmacology and toxicology

Taika

Bouckandou

Souza

et al. 2018

Journal of Ethnopharmacology

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“…With the development and popularization of computer image processing technology, quickly extracting the required information from an image has become a popular research topic in the field of remote sensing (Sezgin and Sankur, 2004;He et al, 2009;Blaschke, 2010;McKown et al, 2010). Based on previous research, we found that image analysis software such as Photoshop and Image J were generally used in the calculation of leaf vein structure (Hüve et al, 2010;Kengni et al, 2016). These methods were not only time-consuming and laborious but also likely to cause great human error.…”

Section: Introductionmentioning

confidence: 99%

A Fast and Automatic Method for Leaf Vein Network Extraction and Vein Density Measurement Based on Object-Oriented Classification

Zhu

Yao

et al. 2020

Front. Plant Sci.

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Rapidly determining leaf vein network patterns and vein densities is biologically important and technically challenging. Current methods, however, are limited to vein contour extraction. Further image processing is difficult, and some leaf vein traits of interest therefore cannot be quantified. In this study, we proposed a novel method for the fast and accurate determination of leaf vein network patterns and vein density. Nine tree species with different leaf characteristics and vein types were applied to verify this method. To overcome the image processing difficulties at the microscopic scale, we adopted the remote object-oriented classification method applied comprehensively in the field of remote sensing research. The key to this approach is to determine the universally applicable leaf vein extraction threshold values (scale parameter, shape parameter, compactness parameter, brightness feature, spectral feature and geometric feature). Based on our analysis, the following recommended threshold values were determined: the scale parameter was 250, the shape parameter was 0.7, the compactness parameter was 0.3, the brightness feature value was 230∼280, the spectral feature value was 180∼230, and the geometric feature value was less than 2. With the optimal extraction parameters applied, the extraction precision was above 96.40% on average for the nine species studied. The leaf vein density calculation rate increased by more than 87.3% compared to that of the traditional methods. The results showed that this method is accurate, fast, flexible and complementary to existing technologies. It is an effective tool for the fast extraction of vein networks and the exploration of leaf vein characteristics, particularly for large-scale studies in plant vein physiology.

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Antityphoid properties and toxicity evaluation of Harungana madagascariensis Lam (Hypericaceae) aqueous leaf extract

Cited by 26 publications

References 24 publications

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

An overview of anti-diabetic plants used in Gabon: Pharmacology and toxicology

A Fast and Automatic Method for Leaf Vein Network Extraction and Vein Density Measurement Based on Object-Oriented Classification

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