Antiulcer activity of hydroalcoholic extract of unripe fruit of carica papaya in experimental rats

Abstract

Background: Carica papaya has previously reported antioxidant, analgesic and anti-inflammatory, antibacterial and anti-histaminic activity. Peptic ulcer disease involves inflammation and oxidative stress, so hydroalcoholic extract of Carica papaya fruits may have strong potential for an antiulcer agent. Aim and objectives of the study were in this study pharmacological evaluation of antiulcer effect of hydroalcoholic extract of Carica papaya fruits was performed by pyloric ligation induced gastric ulcers.Methods: Preliminary phytochemical investigation, estimation of phenolic and flavonoid content, In vitro antioxidant activities, antiulcer activity to find out the efficacy of hydroalcoholic extract of Carica papaya fruits.Results: Treatment with 500 mg/kg of hydroalcoholic extract of Carica papaya fruits efficacious in reducing ulcer index in pyloric ligation induced gastric ulcer model. Hydroalcoholic extract Carica papaya of showed a dose dependent decrease in ulcer and reduces ulcer index which was supported by morphological and histological studies.Conclusions: Thus it can be concluded that hydroalcoholic extract of Carica papaya fruits have antiulcer activity, which can be attributed to its antioxidant mechanism of action.

Anti-Ulcer Agents: A Pharmacological Update of the Past Ten Years

“…The fruit of this plant contains papain which is responsible for anti-ulcer activity [9]. Hydroalcoholic extract of unripe fruit of c. papay was evaluated in pylorus ligation induced ulcer model and the result showed reduction in the ulcer index [39]. In a recent study, the aqueous seed extract of this plant with the doses 50 and 100 mg/kg intraperitoneally was evaluated in rats against ethanolinduced gastric ulcer which protected the gastric mucosa against ethanol effect by significantly (p<0.001) decreased ulcer index, as a result reducing the gastric juice volume and gastric acidity [40].…”