Antiulcer Activity of Indigenous Plant<i>Operculina turpethum</i>Linn.

Ignatius, Vidya; Narayanan, M.; Subramanian, Venkataraman; Periyasamy, Balasubramanian Maruthaiveeran

doi:10.1155/2013/272134

Cited by 16 publications

(17 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[12][13][14] Previous reports have shown that O. turpethum possesses hepatoprotective, antiulcer, antidiabetic, and anti-inflammatory activities. 13,15,16 This study was aimed at the evaluation of the analgesic and antioxidant activities of the methanolic extract of O. turpethum in mice. …”

Section: -10mentioning

confidence: 99%

Analgesic and antioxidant activities of the methanolic extract of Operculina turpethum leaves in mice

Ezeja¹,

Onoja²,

Omeh³

et al. 2015

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

Section: -10mentioning

confidence: 99%

Analgesic and antioxidant activities of the methanolic extract of Operculina turpethum leaves in mice

Ezeja¹,

Onoja²,

Omeh³

et al. 2015

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

“…One hour after gavage, one millilitre of 70 % ethanol in 250 mM HCl was delivered via oral cannula to the stomach of all the animals and the animals were humanely sacrificed 1 h later. The stomachs were dissected along the greater curvature and rinsed in normal saline in order to observe and score the lesions produced 15 .…”

Section: Antiulcer Activity Study Ethanol / Hcl-induced Gastric Ulcermentioning

confidence: 99%

“…Five animals were randomly selected from each group 4 h, 24 h and 72 h after drug therapy, and sacrificed with the stomach examined to determine the curative properties of the herbal drug, viz-a-viz, its time of onset and duration of action. Ulcer was scored as earlier described 1,15 .…”

Section: Ethanol / Hcl-induced Gastric Ulcers (Curative)mentioning

confidence: 99%

Antiulcer Activity of Aqueous Extract of Fresh Leaf of Brassica Oleraceae Linn. Var. Acephala (D.C) Alef) (Brassicaceae)

Agbaje¹,

Esther²,

Okpara³

et al. 2013

Int. Res. J. Pharm.

View full text Add to dashboard Cite

Brassica oleraceae (BOL) is the common cabbage and a familiar garden plant, widely used as spice all over the world. Cabbage is an excellent source of Vitamin C and has been widely employed locally to treat acute inflammation and peptic ulcers. The present study aimed at evaluating the anti¬ulcer activity of Brassica oleraceae, while identifying the phytoconstituents responsible for the observed effects and exploring some of the possible mechanisms of its anti¬ulcer activity, using standard laboratory procedures. Doses of 100, 300 and 750 mg / kg of Brassica oleraceae were separately administered to groups of overnight fasted rats, with appropriate standard drugs using Ethanol / HCl, Indomethacin and Cysteamine models to explore anti¬ulcer property of BOL on the stomach and duodenum respectively. The extract in a dose¬ dependent fashion, offered better protection against the ulcerogens in the gastric ulcer models, when compared with the positive control groups. However, the smallest dose of 100 mg / kg recorded the highest percentage protection in the cysteamine group. Up to 1200 mg / kg i.p and 10,000 mg / kg oral doses of Brassica oleraceae did not produce any mortality in mice. Phytochemical constituents identified included alkaloids, tannins, cardiac glycosides, flavonoids, phlobatannins, anthraquinones and saponins. The pH was 8.5. The present study has validated the local use of Brassica oleraceae in the treatment of peptic ulcer and the speculated mechanisms of action could be through acid neutralization, cytoprotection and antioxidation by flavonoids

show abstract

“…Operculina turpethum (L.)Silva Manso is a stout perennial climber which is reported to posses hepatoprotective, anticancer, antioxidant, antisecretory, ulcer protective, and antimicrobial activity [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Preliminary evaluation of hepatoprotective potential of polyherbal formulation

Ghosh¹,

Anindita²,

Seth³

et al. 2015

J Intercult Ethnopharmacol

View full text Add to dashboard Cite

Aim:The aim of this study was to investigate the antioxidant and hepatoprotective effects of the polyherbal formulation (PHF)containing Cajanus cajan (L.)Millsp., Lawsonia inermis L. Linn, Mimosa pudica L., Uraria picta (Jacq.)DC. and Operculina turpethum (L.)Silva Manso on carbon tetrachloride (CCl4)induced acute liver damage in albino rats.Materials and Methods:The groups of animals were administered with PHF at the doses 100, 200 and 400 mg/kg b.w. (per oral [p.o.])once in a day for 7 days and at day 6th and 7th the animals were administrated with Carbon tetrachloride (1.0 mL/kg b.w. 50% v/v with olive oil,; p.o.). The effect of PHF on serum glutamine pyruvate transaminase (SGPT), serum glutamine oxaloacetate transaminase, alkaline phosphatase (ALP)and total bilirubin were determined in CCl4 - induced hepatotoxicity in rats. Further, the effects of PHF on glutathione (GSH), superoxide dismutase (SOD)level and lipid peroxidation (LPO)activity were also investigated.Results:The results demonstrated that PHF (400 mg/kg b.w.)significantly reduces the CCl4 induced increase in level of serum SGPT, serum ALP and total bilirubin. PHF (400 mg/kg b.w.)prevents the depletion level of GSH and decrease in the activity of SOD in CCl4 -induced liver injury in rats. In addition, PHF also showed a significant decrease in the LPO levels signifying the potent antioxidant activity.Conclusion:All our findings suggest that PHF could protect the liver cells from CCl4 - induced liver damages and the mechanism may be through the anti-oxidative effect of PHF.

show abstract

Antiulcer Activity of Indigenous PlantOperculina turpethumLinn.

Cited by 16 publications

References 30 publications

Analgesic and antioxidant activities of the methanolic extract of Operculina turpethum leaves in mice

Analgesic and antioxidant activities of the methanolic extract of Operculina turpethum leaves in mice

Antiulcer Activity of Aqueous Extract of Fresh Leaf of Brassica Oleraceae Linn. Var. Acephala (D.C) Alef) (Brassicaceae)

Preliminary evaluation of hepatoprotective potential of polyherbal formulation

Contact Info

Product

Resources

About