Antiulcer Activity of Methanol Extract of &lt;b&gt;&lt;i&gt;Melastoma malabathricum&lt;/i&gt;&lt;/b&gt; Leaves in Rats

Zabidi, Zalina; Zainulddin, Wan Noraziemah Wan; Mamat, Siti Syariah; Din, Syafawati Shamsahal; Kamisan, Farah Hidayah; Yahya, Farhana; Ismail, Nurul Ain; Rodzi, R.; Hassan, Heba A.; Mohtarrudin, Norhafizah; Somchit, M. N.; Zakaria, Zaki Yamani

doi:10.1159/000337406

Cited by 18 publications

(18 citation statements)

References 20 publications

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“…Researchers have proved the antinociceptive, anti-inflammatory, antipyretic [15, 16], antidiarrhoeal [17], antimicrobial [18], antiproliferative and antioxidant [19], antiulcer activity [20], acute toxicity evaluation, antibacterial, antioxidant and immunomodulatory effects and hepatoprotective activity [21, 22] of the plant. However, this plant is not scientifically explored for its antiarthritic activity.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Melastoma malabathricum Linn attenuates complete freund’s adjuvant-induced chronic inflammation in Wistar rats via inflammation response

Kumar

Bhatt

Sharma

et al. 2016

BMC Complement Med Ther

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BackgroundNatural products use for arthritis treatment is gaining importance in the medical worldt. Various studies reports medical importance of Melastoma malabathricum Linn. (MM) (Melastomataceae), also known as “putki,” has a broad range of health benefits, for its free radical scavenging constituents. The current investigation scrutinizes the antioxidant and anti-inflammatory effect of MM against adjuvant-induced arthritis in experimental rats.MethodsHigh-performance thin layer chromatography (HPTLC) was used for estimation of phytochemical-constituents present in the MM extract. Protective effect of MM extract in Wistar rats was estimated using CFA-induced model. The rats were divided into different groups with six rats in each group. All animals received oral administration of MM and indomethacin for 28 days. The body weight and arthritic score were scrutinized at regular intervals. At the end of experimental protocol, the rats were sacrificed, and blood samples were used for antioxidant, hematological parameters, pro-inflammatory and inflammatory mediator, respectively. Histopathological observation was used to evaluate the protective effect of MM extract.Result & discussionCurrent study confirmed the preventive effect of MM against adjuvant-induced paw edema, paw redness and arthritic progression. MM significantly (P < 0.001) modulated the oxidative stress parameters as well as hematological parameter induced by CFA. The result also altered the distorted level of proinflammatory mediators and inflammatory mediator, which further reinforce the implication of MM in CFA induced arthritis. Histological analyses of joints of rats showed a reduction in the synovial hyperplasia and mononuclear infiltration in the MM treated group which provides evidence for the antiarthritic effect of MM.ConclusionFrom above parameters our study states that the MM is capable of restraining the alteration produced via adjuvant-induced arthritis in aminals. The repressing effect of MM could be attributed, at least in part, to antioxidant, hematological and anti-inflammatory effect.Graphical abstractFigure Caption: Melastoma Malabathricum Linn Attenuates Complete Freund’s Adjuvant-Induced Chronic Inflammation in Wistar rats by Inflammation Response

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Melastoma malabathricum Linn attenuates complete freund’s adjuvant-induced chronic inflammation in Wistar rats via inflammation response

Kumar

Bhatt

Sharma

et al. 2016

BMC Complement Med Ther

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“…The solvent was then evaporated under reduced pressure (204 mbar) and controlled temperature (40°C) using a vacuum rotary evaporator (Buchi Rotavapor R210/215, Switzerland). The whole processes were repeated twice for the remaining residue [11]. …”

Section: Methodsmentioning

confidence: 99%

Amelioration of Paracetamol-Induced Hepatotoxicity in Rat by the Administration of Methanol Extract ofMuntingia calaburaL. Leaves

Mahmood

Mamat

Kamisan

et al. 2014

BioMed Research International

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Muntingia calabura L. is a tropical plant species that belongs to the Elaeocarpaceae family. The present study is aimed at determining the hepatoprotective activity of methanol extract of M. calabura leaves (MEMC) using two models of liver injury in rats. Rats were divided into five groups (n = 6) and received 10% DMSO (negative control), 50 mg/kg N-acetylcysteine (NAC; positive control), or MEMC (50, 250, and 500 mg/kg) orally once daily for 7 days and on the 8th day were subjected to the hepatotoxic induction using paracetamol (PCM). The blood and liver tissues were collected and subjected to biochemical and microscopical analysis. The extract was also subjected to antioxidant study using the 2,2-diphenyl-1-picrylhydrazyl-(DPPH) and superoxide anion-radical scavenging assays. At the same time, oxygen radical antioxidant capacity (ORAC) and total phenolic content were also determined. From the histological observation, lymphocyte infiltration and marked necrosis were observed in PCM-treated groups (negative control), whereas maintenance of hepatic structure was observed in group pretreated with N-acetylcysteine and MEMC. Hepatotoxic rats pretreated with NAC or MEMC exhibited significant decrease (P < 0.05) in ALT and AST enzymes level. Moreover, the extract also exhibited good antioxidant activity. In conclusion, MEMC exerts potential hepatoprotective activity that could be partly attributed to its antioxidant activity and, thus warrants further investigations.

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“…The solvent was then evaporated under reduced pressure (204 mbar) and controlled temperature (40°C) using a vacuum rotary evaporator (Buchi Rotavapor R210/215, Switzerland). The residue was collected and subjected to the similar extraction process for another two times [20]. …”

Section: Methodsmentioning

confidence: 99%

Hepatoprotective Activity of Methanolic Extract ofBauhinia purpureaLeaves against Paracetamol-Induced Hepatic Damage in Rats

Yahya

Mamat

Kamarolzaman

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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In an attempt to further establish the pharmacological properties of Bauhinia purpurea (Fabaceae), hepatoprotective potential of methanol extract of B. purpurea leaves (MEBP) was investigated using the paracetamol- (PCM-) induced liver toxicity in rats. Five groups of rats (n = 6) were used and administered orally once daily with 10% DMSO (negative control), 200 mg/kg silymarin (positive control), or MEBP (50, 250, and 500 mg/kg) for 7 days, followed by the hepatotoxicity induction using paracetamol (PCM). The blood samples and livers were collected and subjected to biochemical and microscopical analysis. The extract was also subjected to antioxidant study using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay with the total phenolic content (TPC) also determined. From the histological observation, lymphocyte infiltration and marked necrosis were observed in PCM-treated groups (negative control), whereas maintenance of the normal hepatic structural was observed in group pretreated with silymarin and MEBP. Hepatotoxic rats pretreated with silymarin or MEBP exhibited significant decrease (P < 0.05) in ALT and AST enzyme level. Moreover, the extract also exhibited antioxidant activity and contained high TPC. In conclusion, MEBP exerts potential hepatoprotective activity that could be partly attributed to its antioxidant activity and high phenolic content and thus warrants further investigation.

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Antiulcer Activity of Methanol Extract of <b><i>Melastoma malabathricum</i></b> Leaves in Rats

Cited by 18 publications

References 20 publications

RETRACTED ARTICLE: Melastoma malabathricum Linn attenuates complete freund’s adjuvant-induced chronic inflammation in Wistar rats via inflammation response

RETRACTED ARTICLE: Melastoma malabathricum Linn attenuates complete freund’s adjuvant-induced chronic inflammation in Wistar rats via inflammation response

Amelioration of Paracetamol-Induced Hepatotoxicity in Rat by the Administration of Methanol Extract ofMuntingia calaburaL. Leaves

Hepatoprotective Activity of Methanolic Extract ofBauhinia purpureaLeaves against Paracetamol-Induced Hepatic Damage in Rats

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