Antiulcer and in vitro antioxidant activities of Jasminum grandiflorum L.

Umamaheswari, Muthuswamy; Asokkumar, Kuppusamy; Rathidevi, R.; Sivashanmugam, A.T.; Subhadradevi, Varadharajan; Ravi, T. K.

doi:10.1016/j.jep.2006.10.017

Cited by 110 publications

(71 citation statements)

References 21 publications

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“…The reduction in gastric fluid volume, total acidity and an increase in the pH of the gastric fluid in APL rats proved the anti secretary activity of JGLE. Additionally, JGLE completely healed the ulcer within 20 days of treatment in AC model as evidenced by histopathological studies [22] . In our study alcian blue stain is used to evaluate the extent of mucus secretion by mucosal cells carried out in histological and histochemical examination of gastric glandular mucosa revealed that as when compared to stress induced stomach (Control): lot of mucosal surface layer distortions and ulceration are visible, (Fig.…”

Section: Discussionmentioning

confidence: 83%

“…Both the antisecretory and cytoprotection hypothesis were evaluated. The antioxidant activity of Jasminum grandiflorum L. (JGLE) has been assayed by using in vitro methods like 2,2-diphenyl-1-picrylhydrazylhydrate (DPPH) assay [22] . Phytochemical investigation of Byrsonima crassa leaves consists of 5phenolic compounds may probably revealed antiulcerogenic effects; The MeOH extract reduced the ulceration by 93 and 99% only at the doses of 500 and 1000 mg kg −1 .…”

Section: Discussionmentioning

confidence: 99%

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Cytoprotective Effect of UlGen, a Polyherbal Formulation against Physical and Chemical Factor Induced Gastric Ulcers in Wister Albino Rats

Muralidhar¹,

Balaji²,

Bandopadhyay³

et al. 2009

American J. of Pharmacology and Toxicology

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Problem statement: UlGen, a Polyherbal formulation, was investigated for its possible Ulcero-protective activity in ulcerogen and Cold-restraint stress induced Wister rats (Rattus rattus). Oral administration of UlGen, at a dose of 800 mg kg −1 significantly protected the onset of coldresistance stress induced ulcerations. Approach: It significantly inhibited gastric ulceration induced by alcohol and aspirin. Control group: Alcohol 80% induced ulcer was 42.00±2.30 and in UlGen treated rats showed 10.00±1.62. Using alcian blue stain to study the mucus secretion by mucosal cells carried out histological examination of gastric glandular mucosa. Results: The volume and acidity of gastric juice in pyloric-ligated rats was reduced in treated rats. Gastric volume (mL 100 g −1 ) in control rats showed 4.12±0.32 and in UlGen treated rats showed 2.50±0.20. Conclusion: UlGen, Cytoprotective effect may be due to the enhancement of defensive mechanism through an improvement of gastric cytoprotection as well as acid inhibition.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Cytoprotective Effect of UlGen, a Polyherbal Formulation against Physical and Chemical Factor Induced Gastric Ulcers in Wister Albino Rats

Muralidhar¹,

Balaji²,

Bandopadhyay³

et al. 2009

American J. of Pharmacology and Toxicology

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“…Results of study also revealed that plant extract caused a significant decrease in ulcerative lesions, gastric volume and acidity which was comparable to synthetic antiulcer drug. Phytochemical investigations has demonstrated the presence of alkaloids, flavonoids, phenolic compounds, saponins, carbohydrates, carotenoids and glycosides as active constituents (Umamaheswari et al, 2007).…”

Section: Jasminum Grandiflorummentioning

confidence: 99%

Medicinal plants with gastroprotective potential

Majeed¹,

Khaliq²,

Aslam³

et al. 2015

Bangladesh J Pharmacol

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<p class="Abstract">Peptic ulcer disease (PUD) is a main source of morbidity and mortality worldwide. It is characterized by erosions in mucosal linings of stomach and duodenum. Non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori are mainly responsible for peptic ulcer disease. Histamine receptor blockers and proton pump inhibitors are most prominent therapies in the treatment of peptic ulcer. However, severe adverse effects of NSAIDs have been reported. Therefore, focus is now diverted towards herbal formulations of medicinal plants for the treatment of ulcer. Plants contain different phytoconstituents which are responsible for increasing defensive mechanisms of body against peptic ulcer. The current review focuses on the commonly used gastroprotective plants as antiulcer agents.</p><p> </p>

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“…Further ethanol is metabolized in the body and releases superoxide anion and hydroperoxy free radicals. It has been found that oxygen-derived free radicals are implicated in the mechanism of acute and chronic ulceration in the stomach (Umamaheswari et al, 2007). HCl, a well known necrotizing agent, was also mixed with ethanol to augment the formation of gastric lesions.…”

Section: Discussionmentioning

confidence: 99%