Antiulcerogenic activity of Anogeissus pendula hydroalcoholic extract on pylorus ligated induced gastric ulcers in Albino Wistar rats

Danai, Priyanka; Patel, Saraswati; Pandey, Varsha; Singh, Prakash; Yadav, Govind; Kumar, Amit; Agarwal, Teena

doi:10.1016/j.phyplu.2021.100127

Cited by 9 publications

(4 citation statements)

References 31 publications

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“…For example, Flavonoids are well-known antioxidants that protect the stomach mucosa by clearing reactive oxygen species, stabilizing mucous membranes, and increasing gastric mucosal prostaglandin levels (Ahmed & Rahman, 2016;Onwukwe et al, 2018). These active bioactive compounds, according to previous studies, have the ability to boost mucus, bicarbonate, and prostaglandin secretion, as well as counteract the negative effects of reactive oxidants in the gastrointestinal lumen (Sahoo et al, 2016;Danai et al, 2021).…”

Section: Discussionmentioning

confidence: 97%

“…Terpenoids have also been reported to have high antioxidant and antiulcer properties (Mohod & Bodhankar, 2013). In various experimental models of gastric ulcer, terpenoid has also shown anti-secretory and cytoprotective effects (Danai et al, 2021). Thus, the antiulcer activity exhibited by MEMB may due to the presence of tannins, flavonoids, and terpenoids (Sahoo et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

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Protective Effect of Mormodica balsamina Leaf Extract on the Gastric Morphology of Experimental Rats Against Ethanol Induced Gastric Ulcers

Onyemelukwe,

Onwukwe,

Azubuike

et al. 2023

Int. J. Morphol.

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Mormodica balsamina is a valuable medicinal plant that is used to treat wounds and inflammation; its leaves are also used as an antibiotic and in the treatment of stomach pain. This study was conducted to determine the anti-ulcer activity of methanolic leaf extract of Mormodica balsamina on ethanol-induced ulcer in albino rats. A total of 32 rats were used for the study. Groups I and II served as the baseline and negative controls respectively, while groups III-VII served as the test groups. Group I was untreated, while group II received 1ml/kg body weight of the vehicle (2 % DMSO). Three test groups (III -V) received methanol extracts (75 mg, 150 mg, 300 mg/kg body weight respectively) while the other three test groups (VI -VIII) received aqueous extracts (75 mg, 150mg, 300 mg/kg body weight respectively) via oral gavage for seven days prior to ulcer induction. The rats were sacrificed, stomachs excised and ulcers scored. Histological sections were produced and examined. Findings revealed that M. balsamina extracts protected the rats' gastric epithelia from ethanol induced ulceration to varying degree with the high dose (150 and 300 mg/kg) of both extracts offering the best preservation (42 % and 50 % ulcer protective index respectively) when compared to untreated animals. Histological findings correlated with calculated ulcer indices, with treated animals having less severe gastric mucosal lesions. In conclusion, extracts of M. balsamina may possess reasonable antiulcer activities in rats against ethanol induced gastric ulcer.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Protective Effect of Mormodica balsamina Leaf Extract on the Gastric Morphology of Experimental Rats Against Ethanol Induced Gastric Ulcers

Onyemelukwe,

Onwukwe,

Azubuike

et al. 2023

Int. J. Morphol.

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“…Medicinal plants have been used for centuries in different cultures and traditional healing systems around the world as a source of healing [1,2,5,6] . These plants contain natural chemical compounds such as alkaloids, flavonoids, terpenoids, and phenolic which possess pharmacological effects on the animal and human body [3,4] . The compounds can interact with physiological processes and help alleviate symptoms or treat various illnesses and diseases.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profiling, Antimicrobial, Antiproliferative and Apoptotic Effects of Stemodia viscosa Roxb. of Western Ghats Region, India

Anbhule

Moyo

Jagadhane

et al. 2023

Chemistry & Biodiversity

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The present study shows the chemical profile, antimicrobial, antiproliferative, and apoptotic effects of Stemodia viscosa extracts. Thirteen bioactive compounds were identified in the 80 % ethanolic extract by GC/MS analysis. The acetone extract exhibited a higher content of flavonoids and phenols of 805.10 μg QE/mg DW and 89.31 μg GAE/mg DW extracts, respectively. Furthermore, the acetone extract possessed the highest antioxidant activity (IC50=9.96 μg/mL). The 80 % ethanolic extract exhibited significant antimicrobial activity; the highest activity was observed against Staphylococcus aureus with a zone of inhibition of 25±0.51 mm, MIC value of 4 mg/mL, and MBC value of 8 mg/mL. The antiproliferative results revealed the presence of anticancer activity with an IC50=91.562 and 74.362 μg/mL against the B16F10 skin and COLO205 colon cancer cells, respectively. The flow cytometric analysis shows that the plant extracts cause cancer cell death through the induction of apoptosis. Our findings confirmed that Stemodia viscosa is a potential source of biologically active compounds.

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“…With a 10% frequency in human civilization, peptic ulcer disease (PUD) is a widespread gastrointestinal condition [ 1 ], which affects the stomach’s ability to balance aggressive and protective forces [ 2 ]. Along with exogenous factors such as alcohol consumption and the use of non-steroidal anti-inflammatory medicines, aggressive factors also include the production of pepsin and stomach acid, active free radicals and oxidants, leukotrienes, and endothelins [ 3 ]. In contrast, defensive factors include gastric mucus, prostaglandins (PGs), bicarbonate, nitric oxide (NO), growth factors, and antioxidant enzymes or antioxidant peptides, such as glutathione (GSH) [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Metabolites Profiling and Bioassays Reveal Bassia indica Ethanol Extract Protective Effect against Stomach Ulcers Development via HMGB1/TLR-4/NF-κB Pathway

El-Gendy

Taher²,

Elgamal

et al. 2023

Antioxidants

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Clinical manifestation of gastric ulcers is frequent, in addition to their costly drug regimens, warranting the development of novel drugs at lower costs. Although Bassia indica is well characterized for its anti-inflammatory and antioxidant potential, capacity of its ethanol extract (BIEE) to prevent stomach ulcers’ progression has not been reported. A nuclear protein termed high-mobility group box 1 (HMGB1) plays a key role in the formation of stomach ulcers by triggering a number of inflammatory responses. The main purpose of the current investigation was to evaluate the in vivo anti-inflammatory and anti-ulcerogenic capabilities of BIEE against ethanol-induced gastric ulcers in rats via the HMGB1/TLR-4/NF-B signaling pathway. HMGB1 and Nuclear factor kappa (NF-B) expression, IL-1β and Nrf2 contents showed an increase along with ulcer development, concurrent with an increase in immunohistochemical TLR-4 level. In contrast, pre-treatment with BIEE significantly reduced HMGB1 and Nuclear factor kappa (NF-B) expression levels, IL-1β and Nrf2 contents and ulcer index value. Such protective action was further confirmed based on histological and immunohistochemical TLR-4 assays. Untargeted analysis via UPLC-ESI–Qtof-MS has allowed for the comprehensive characterization of 40 metabolites in BIEE mostly belonged to two main chemical classes, viz., flavonoids and lipids. These key metabolites, particularly flavonoids, suggesting a mediation for the anti-inflammatory and anti-ulcerogenic properties of BIEE, pose it as a promising natural drug regimen for treatment of stomach ulcers.

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Antiulcerogenic activity of Anogeissus pendula hydroalcoholic extract on pylorus ligated induced gastric ulcers in Albino Wistar rats

Cited by 9 publications

References 31 publications

Protective Effect of Mormodica balsamina Leaf Extract on the Gastric Morphology of Experimental Rats Against Ethanol Induced Gastric Ulcers

Protective Effect of Mormodica balsamina Leaf Extract on the Gastric Morphology of Experimental Rats Against Ethanol Induced Gastric Ulcers

Phytochemical Profiling, Antimicrobial, Antiproliferative and Apoptotic Effects of Stemodia viscosa Roxb. of Western Ghats Region, India

Metabolites Profiling and Bioassays Reveal Bassia indica Ethanol Extract Protective Effect against Stomach Ulcers Development via HMGB1/TLR-4/NF-κB Pathway

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