Antiulcerogenic effect of Cuphea ignea extract against ethanol-induced gastric ulcer in rats

Abstract

BackgroundCuphea ignea is one of the herbal resources belonging to Lythraceae family. Some species of this family have been used traditionally in South and Central America’s folk medicine for treating stomach disorders. Therefore, the present study was performed to evaluate the gastropreventive effect of aqueous ethanolic extract of C. ignea aerial parts on ethanol-induced gastric ulcer.MethodsGastric ulcers were induced in Sprague Dawley rats using one oral dose of absolute ethanol (1.5 mL/rat). The C. ignea aerial parts extract at doses of 250 and 500 mg/kg body weight and ranitidine (a reference drug) at a dose of 30 mg/kg body weight were orally administrated daily for 7 days before ulcer induction. One hour after ethanol administration blood samples were collected and then stomachs of sacrificed rats were subjected to biochemical, macroscopic and microscopic studies.ResultsOral administration of C. ignea extract significantly attenuated gastric ulcer as revealed by significant reduction in the gastric ulcer index and volume of gastric juice while significantly increased preventive percentage, gastric pH value and pepsin activity. Pre-treatment of C. ignea extract markedly improved the serum level of TNF-α, the gastric MPO activity and NO content. Furthermore, C. ignea pre-treatment significantly increased the gastric levels of enzymatic and non- enzymatic antioxidants namely CAT, SOD, GSH-Px, and GSH with concomitant reduction in MDA level compared with those in the ethanol group. These results were further supported by histopathological findings which revealed the curing effect of C. ignea on the hemorrhagic shock induced by ethanol toxicity.ConclusionsC. ignea extract showed a potential gastroprotective effect on ethanol-induced gastric ulcer, and its effect may be mediated through suppression of oxidative stress and gastric inflammation.

Protective Effects of Radix Sophorae Flavescentis Carbonisata-Based Carbon Dots Against Ethanol‐Induced Acute Gastric Ulcer in Rats: Anti-Inflammatory and Antioxidant Activities

“…The ulcer index (UI) and percentage inhibition were determined using formulas from the literature. 25 , 26 The UI and percentage inhibition were calculated by the following formulas:…”

Study of the Potential Antiulcerous Action of Hydroalcoholic Extracts From Prunella Vulgaris L. Of Romanian Origin

“…The antioxidant effect of flavonoids and phenolcarboxylic acids responsible for the decrease in markers of oxidative stress (MDA -malonyldialdehyde) and the increase in the capacity of enzymatic and nonenzymatic antioxidants (catalase, superoxide dismutase, glutathione peroxidase, high glutathione) has been demonstrated for the polyphenolic extract of Cuphea ignea and of some Salvia species [23,36]. These effects of plant polyphenols have been described by Farzaei MH et al in a systematic analysis concerning the inverse relationship between the intake of polyphenols and peptic ulcer: capture of free radicals, increased synthesis of glutathione and inhibition of the intracellular inflammatory pathway (MAPKprotein kinase activated by a mitogen, ERKregulated extracellular kinase, NF-kBnuclear factor kappa B) [18].…”

Codonopsis Decoction Inhibits Aspirin-Induced Gastric Mucosal Injury in Rats by Regulating COX, COX-1, COX-2, TNF-α, IL-6 and TGF-α

“…IL-6 can activate the central nervous system to regulate injury and defense, and at the same time regulate immune response and acute phase response, which is significantly increased in patients with gastric ulcer [33]. TNF-α is a kind of endogenous multidirectional inflammatory cell factors that can activate neutrophils and continue to damage the gastric mucosa, causing ulcers to be difficult to heal [34]. Aspirininduced the high levels of TNF-α and IL-6 in serum and stomach tissue of rats were also significantly attenuated by Codonopsis decoction at all doses.…”