Antiulcerogenic effects of Campomanesia xanthocarpa

Markman, Blanca Elena Ortega; Bacchi, Elfriede Marianne; Kato, Edna Tomiko Myiake

doi:10.1016/j.jep.2004.04.025

“…24 Plants with flavonoids, tannins, and saponins in their composition are potential sources of antimicrobial agents. 25 These metabolites are described as constituents of the fruit of C. xanthocarpa, 9,11 and this has been confirmed in this study by standard test reactions and thin-layer chromatography. A recent article describes the fruits of C. xanthocarpa as rich in nutritional compounds and monoterpenes constituting their essential oil.…”

Section: Resultssupporting

confidence: 67%

Antidiarrheal Activity ofCampomanesia xanthocarpaFruit

Souza-Moreira

¹

,

Salvagnini

²

,

Santos

³

et al. 2011

Journal of Medicinal Food

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The growing list of drug-resistant microorganisms and the persistence of deaths due to diarrhea are compelling reasons to study plants in search of new therapeutic agents. The chemical constitution and popular use of the edible fruits of Campomanesia xanthocarpa O. Berg motivated this study to assess the antimicrobial and antidiarrheal properties of the fruits. An extract in 70% ethanol was prepared, and its antimicrobial activity was tested against several strains of bacteria by the agar diffusion and microdilution methods. Antidiarrheal activity was analyzed by testing intestinal motility in an animal model. Preliminary phytochemical study indicated the presence of flavonoids, saponins, and tannins in the hydroalcoholic extract. Antimicrobial activity was significant, but the minimum inhibitory concentration proved to be higher than the maximum extract concentration tested. The extract did not show significant activity for intestinal motility. Although this fruit extract did not show great results as an antimicrobial or antidiarrheal agent, the study contributes to the search for new plant agents and could be referred to as a research protocol by investigators in this area.

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“…24 Plants with flavonoids, tannins, and saponins in their composition are potential sources of antimicrobial agents. 25 These metabolites are described as constituents of the fruit of C. xanthocarpa, 9,11 and this has been confirmed in this study by standard test reactions and thin-layer chromatography. A recent article describes the fruits of C. xanthocarpa as rich in nutritional compounds and monoterpenes constituting their essential oil.…”

Section: Resultssupporting

confidence: 67%

“…Beside the widespread consumption of the fruits, its leaves are used as an antidiarrheal, depurative, and anti-inflammatory, and phytochemical analysis has indicated the presence of flavonoids, saponins, and tannins. 7,[9][10][11] Motivated by these considerations, the aim of the present study was to test the fruit of C. xanthocarpa for antimicrobial activity against a range of bacteria and for antidiarrheal activity in mice, by the method of intestinal motility. This fruit was chosen because, besides its promising chemical composition, it is edible and easily found.…”

Section: Introduction Tmentioning

confidence: 99%

Natural Products fromGarcinia brasiliensisasLeishmaniaProtease Inhibitors

Pereira

¹

,

Assis

²

,

Juliano

³

et al. 2011

Journal of Medicinal Food

View full text Add to dashboard Cite

The growing list of drug-resistant microorganisms and the persistence of deaths due to diarrhea are compelling reasons to study plants in search of new therapeutic agents. The chemical constitution and popular use of the edible fruits of Campomanesia xanthocarpa O. Berg motivated this study to assess the antimicrobial and antidiarrheal properties of the fruits. An extract in 70% ethanol was prepared, and its antimicrobial activity was tested against several strains of bacteria by the agar diffusion and microdilution methods. Antidiarrheal activity was analyzed by testing intestinal motility in an animal model. Preliminary phytochemical study indicated the presence of flavonoids, saponins, and tannins in the hydroalcoholic extract. Antimicrobial activity was significant, but the minimum inhibitory concentration proved to be higher than the maximum extract concentration tested. The extract did not show significant activity for intestinal motility. Although this fruit extract did not show great results as an antimicrobial or antidiarrheal agent, the study contributes to the search for new plant agents and could be referred to as a research protocol by investigators in this area.

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“…Despite its popular use, there is scant pharmacological information available on this plant. Markman et al (2004) described the anti-ulcerogenic activity of the alcoholic extract and Fernandes and Vargas (2003) demonstrated mutagenic and anti-mutagenic potential. The chronic treatment of obese rats with the infusion of the leaves of C. xanthocarpa led to a significant decrease in body mass, as well as a reduction in glycemia (Biavatti et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Vinagre

¹

,

Rönnau

²

,

Pereira

³

et al. 2010

Braz. J. Pharm. Sci.

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The objective of this research was to identify the effects of 3-week treatment of normal and streptozotocininduced diabetic rats using a leaf decoction of Campomanesia xanthocarpa Berg. (20 g/L) on physiological, biochemical and histological parameters. Streptozotocin (STZ, 70 mg/kg in citrate buffer, pH 4.5) was administered IP to induce experimental diabetes one week prior to the treatment. STZ caused typical diabetic symptoms: polydypsia, polyuria, polyphagia, hyperglycemia, hypertriglyceridemia and histopathological modifications in the pancreas, liver and kidney. The treatment of diabetic rats using the decoction decreased blood glucose levels, inhibited hepatic glycogen loss, and prevented potential histopathological alterations in the pancreas and kidneys. No differences were found between the control rats treated with the decoction and the control rats maintained on water only. In conclusion, these results suggest that C. xanthocarpa leaf decoction (20g/L) might be useful for diabetes mellitus management, but further pharmacological and toxicological studies are needed. O objetivo deste trabalho foi identificar os efeitos do tratamento com o decocto das folhas de Campomanesia xanthocarpa Berg. (20 g/L), durante 3 semanas, sobre parâmetros fisiológicos, bioquímicos e histológicos de ratos normais e diabéticos induzidos por estreptozotocina. O diabete melito foi induzido uma semana antes de iniciar o tratamento experimental, pela administração IP de estreptozotocina (STZ, 70 mg/ kg em tampão citrato, pH 4.5). Os ratos tratados com STZ apresentaram sintomas típicos de diabete: polifagia, polidipsia, hiperglicemia, hipertrigliceridemia e alterações histopatológicas no pâncreas, fígado e rim. O tratamento dos ratos diabéticos com o decocto diminuiu os níveis de glicose sanguínea, inibiu a degradação do glicogênio hepático e preveniu possíveis alterações histopatológicas no pâncreas e no rim. Nos ratos controles tratados com o decocto não foram verificadas diferenças significativas em relação aos controles tratados com água. Em conclusão, os resultados sugerem que o tratamento com o decocto das folhas de C. xanthocarpa leaf decoction (20 g/L) possa ser útil para o manejo do diabete melito, porém estudos farmacológicos e toxicológicos ainda são necessários.Unitermos: Campomanesia xanthocarpa/farmacognosia. Diabete Melito/estudo experimental. Planta hipoglicemiante. Carboidratos/metabolismo. Lipídeos/metabolismo.

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Antiulcerogenic effects of Campomanesia xanthocarpa

Cited by 85 publications

References 11 publications

Antidiarrheal Activity ofCampomanesia xanthocarpaFruit

Antidiarrheal Activity ofCampomanesia xanthocarpaFruit

Natural Products fromGarcinia brasiliensisasLeishmaniaProtease Inhibitors

Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

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