2019
DOI: 10.4314/tjpr.v18i1.16
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Antiurolithiatic effect of ferulic acid on ethylene glycolinduced renal calculus in experimental rats

Abstract: Purpose: To evaluate the anti-urolithiatic effect of ferulic acid on ethylene glycol-induced kidney stone in a rat model. Methods: Five groups of adult male Sprague-Dawley rats (6 rats/group) were used in this study. Group I rats served as normal control. Renal calculus was induced through ethylene glycol (0.75 % v/v in drinking water) administration to all rats for 28 days except those in group 1. Prior to ethylene glycol treatment, ferulic acid was given orally (gavage) to rats in groups III and IV at doses … Show more

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Cited by 11 publications
(10 citation statements)
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“…In the present therapeutic study, it was also evidently proved that the G. fruticosus BuOH extracts lowered AST levels very significantly (P < 0.001), which was close to K-Cit compared to the lithiatic control in the curative studies. This can be attributed to the fact that abnormal levels of liver enzymes, particularly aminotransferases including alanine aminotransferase (ALT), and aspartate aminotransferase (AST) are prognostic features (indicators) of the damages of liver cells, and the cellular integrity of the kidneys [71,72].…”
Section: Discussionmentioning
confidence: 99%
“…In the present therapeutic study, it was also evidently proved that the G. fruticosus BuOH extracts lowered AST levels very significantly (P < 0.001), which was close to K-Cit compared to the lithiatic control in the curative studies. This can be attributed to the fact that abnormal levels of liver enzymes, particularly aminotransferases including alanine aminotransferase (ALT), and aspartate aminotransferase (AST) are prognostic features (indicators) of the damages of liver cells, and the cellular integrity of the kidneys [71,72].…”
Section: Discussionmentioning
confidence: 99%
“…Hyperoxaluria reduced markedly the antioxidant enzymes (GSH, SOD, GPx, and CAT levels) due to a collapse of the antioxidant defense system, which leads to the formation of kidney stones. Ferulic acid at 80 mg/kg has the ability to increase the levels of these antioxidant enzymes compared to the EG group (1.20 vs. 1.02 U/mg protein, 1.41 vs. 0.94 U/mg protein, 0.72 vs. 0.42 U/mg protein, and 1.20 vs. 0.96 U/mg protein, respectively), while decreasing LPO (0.73 vs. 0.94 U/mg protein), thereby regulating the ROS [34]. In addition, histopathological analysis revealed that ferulic acid treatment significantly protected EG-induced tissue damage in a dose-dependent manner.…”
Section: Ferulic Acidmentioning
confidence: 92%
“…The oral administration of ferulic acid at 40 and 80 mg/kg by Zhao et al [34] showed significant regulation of biochemical parameters in serum and kidneys in a dose-dependent manner. At 80 mg/kg, aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) in the kidneys were markedly mitigated by ferulic acid to near normal (5.12 ± 0.38 U/mg protein, 31.21 ± 1.13 U/mg protein, 28.36 ± 0.98 U/mg protein, 24.96 ± 0.89 U/mg protein, and 9.36 ± 0.28 U/mg protein, respectively) [34]. Simultaneously, this bioactive molecule significantly decreased renal markers (calcium, oxalate, uric acid, magnesium, urea, creatinine, and total protein) in urine and plasma compared to the EG-treated group.…”
Section: Ferulic Acidmentioning
confidence: 99%
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