Antiviral activities of <i>Glycyrrhiza uralensis</i> components against Singapore grouper iridovirus

Li, Mengmeng; Liu, Mingzhu; Wei, Hongling; Huang, Lin; Yu, Qing; Huang, Shuaishuai; Li, Jinyuan; Li, Pengfei

doi:10.1111/jwas.12878

Cited by 9 publications

(4 citation statements)

References 39 publications

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“…studied the antiviral effects of Glycyrrhiza uralensis against SGIV and identified several major components, including glycyrrhizin, glycyrrhetinic acid, liquiritin, isoliquiritigenin and liquiritigenin. 88 These studies highlight the potential of natural compounds as effective treatments for SGIV infections, which can cause significant damage to fish farms and result in high economic losses.…”

Section: Antiviral Effect Of Medicinal Plants and Their Active Ingred...mentioning

confidence: 99%

The antiviral activity of currently used medicinal plants in aquaculture and structure–activity relationship of their active ingredients

Zhang

Shan

et al. 2023

Reviews in Aquaculture

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Aquaculture is an important source of high‐quality protein and plays a crucial role in ensuring global food security. However, viral diseases have caused significant damage to aquaculture production, making it necessary to develop effective measures to treat them. Although drugs are commonly used to treat viral diseases, recent studies have shown that crude extracts of medicinal plants and their active ingredients have potential applications in the treatment of aquatic viral diseases. Furthermore, natural small molecule compounds from herbs could be used as lead compounds to develop more potent anti‐aquatic virus derivatives. As such, there is an urgent need to develop and apply drugs for the treatment of viral disease outbreaks in aquaculture. In this review, we summarize previous studies on the efficacy of different agents used as antiviral drugs in aquaculture, with a focus on their protective effects. Additionally, we highlight the potential of active natural compounds isolated from medicinal plants, which could serve as lead compounds for developing aquatic‐specific drugs. However, the relationship between the structure of a compound and its antiviral activity in aquaculture has not been clearly elucidated, posing a challenge for further drug optimisation. Therefore, this study also analyses the structure–activity relationship of several reported lead compounds and their derivatives in aquaculture, providing a reference for subsequent drug development efforts.

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Section: Antiviral Effect Of Medicinal Plants and Their Active Ingred...mentioning

confidence: 99%

The antiviral activity of currently used medicinal plants in aquaculture and structure–activity relationship of their active ingredients

Zhang

Shan

et al. 2023

Reviews in Aquaculture

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“…As previously mentioned, Glycyrrhiza uralensis (GUF) has a variety of beneficial effects, including but not limited to antiviral, antibacterial, and anti-inflammatory activities. Li et al [130] investigated the antiviral effects of licorice against SGIV and found several major components of GUF, glycyrrhizin, glycyrrhetinic acid, liquiritin, isoliquiritigenin, and liquiritigenin. Although none of them exhibited significant anti-SGIV effects, the aqueous extract of GUF had significant anti-SGIV infection activity in a concentration-dependent manner.…”

Section: Medicinal Plants Against Dna Viruses 221 Medicinal Plants Ag...mentioning

confidence: 99%

“…f. Qct Promoting the recognition of SGIV and activating the IFN pathway [123,124] Curcuma kwangsiensis CKEE; urdione Inhibiting virus replication [126] Lonicera japonica Thunb. IAA, IAB, IAC, CA, LT, IS Inhibiting virus replication [127] Viola philippica Extract Disturbing virus binding, entry, and replication in host cells [129] Glycyrrhiza uralensis (GUF) Extract Impacting the binding of virus particles to cell receptors and the replication of viruses in host cells [130] WSSV Green tea EGCG Inducing gene expression involved in the innate immune response [138,139] Typha angustifolia Naringenin (NAR) Restraining early viral gene replication [140] Pericarpium Citri Reticulatae Hesperidin Improving nonspecific immunity [142] Gardenia…”

Section: Medicinal Plants Against Wssvmentioning

confidence: 99%

Review of Medicinal Plants and Active Pharmaceutical Ingredients against Aquatic Pathogenic Viruses

Liao

Huang

Han

et al. 2022

Viruses

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Aquaculture offers a promising source of economic and healthy protein for human consumption, which can improve wellbeing. Viral diseases are the most serious type of diseases affecting aquatic animals and a major obstacle to the development of the aquaculture industry. In the background of antibiotic-free farming, the development and application of antibiotic alternatives has become one of the most important issues in aquaculture. In recent years, many medicinal plants and their active pharmaceutical ingredients have been found to be effective in the treatment and prevention of viral diseases in aquatic animals. Compared with chemical drugs and antibiotics, medicinal plants have fewer side-effects, produce little drug resistance, and exhibit low toxicity to the water environment. Most medicinal plants can effectively improve the growth performance of aquatic animals; thus, they are becoming increasingly valued and widely used in aquaculture. The present review summarizes the promising antiviral activities of medicinal plants and their active pharmaceutical ingredients against aquatic viruses. Furthermore, it also explains their possible mechanisms of action and possible implications in the prevention or treatment of viral diseases in aquaculture. This article could lay the foundation for the future development of harmless drugs for the prevention and control of viral disease outbreaks in aquaculture.

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“…Results showed that metformin exerts a dose‐dependent antiviral effect by disrupting SGIV‐Gx particles, suggesting its great potential in dealing with SGIV‐Gx infection. Li et al (2022) assessed the in vivo antiviral effect of Glycyrrhiza uralensis components against SGIV infection. Results showed that the ingredients did not have significant effects against SGIV infection, whereas aqueous extract (GUF) showed significant anti‐SGIV infection activity in a concentration‐dependent manner, and it also destroyed the structure of virus particles, which is similar to the function of metformin.…”

Section: Disease Resistancementioning

confidence: 99%

Presentations by young Chinese aquaculture scientists: From the 2021 China Society of Fisheries—Annual Conference of Youth Scholars

Wang

2022

J World Aquaculture Soc

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Young scientists are the most active force driving scientific advancement and technological innovation. Nonetheless, young scholars also face challenges such as heavy workloads, shortage of research-focused hours, high competition in grant application, and securing an academic job, among others. Mentorship from supervisors and senior peers is important to encourage and reassure the scientific endeavors of young scholars. Favorable policies and activities arranged by public agencies or academic societies are also essential for nurturing and promoting the successful establishment of young scholars. Chinese young scientists have been making great contributions to aquaculture research and applications. The China Society of Fisheries organized the Annual Conference of Youth Scholars in Shanghai on October 18, 2021. There were over 300 attendees to this meeting, which covered the topics of aquaculture techniques and equipment, biotechnologies and breeding, nutrition and feeds, diseases and quality security, aquaculture resources and conservation, and aquaculture economy and management. Here, we summarize some representative work by the attendees who were selected for this special issue, which partially reflects the recent research focus on young aquaculture scientists in China.The healthy and sustainable development of aquaculture depends heavily on research on nutritional feeds in terms of precise nutritional requirements of aquatic animals. The largemouth bass, Micropterus salmoides, characterized by its fast growth and delicious taste, is currently a major species of freshwater aquaculture in China. According to the China Fishery Statistical Yearbook report, the total production of farmed largemouth bass in 2020 was more than 619,500 tons, and the national demand for this fish is also increasing yearly (China Fishery Yearbook, 2021). To date, the requirement of each vitamin of the largemouth bass has its own specific and irreplaceable function, so it is necessary to investigate the optimal level of usage one by one. The requirement for fat-soluble vitamins, including vitamins

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Antiviral activities of Glycyrrhiza uralensis components against Singapore grouper iridovirus

Cited by 9 publications

References 39 publications

The antiviral activity of currently used medicinal plants in aquaculture and structure–activity relationship of their active ingredients

The antiviral activity of currently used medicinal plants in aquaculture and structure–activity relationship of their active ingredients

Review of Medicinal Plants and Active Pharmaceutical Ingredients against Aquatic Pathogenic Viruses

Presentations by young Chinese aquaculture scientists: From the 2021 China Society of Fisheries—Annual Conference of Youth Scholars

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