2013
DOI: 10.1186/1743-422x-10-259
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Antiviral activities of Indonesian medicinal plants in the East Java region against hepatitis C virus

Abstract: BackgroundHepatitis C virus (HCV) is a major cause of liver disease and a potential cause of substantial morbidity and mortality worldwide. The overall prevalence of HCV infection is 2%, representing 120 million people worldwide. Current standard treatment using pegylated interferon and ribavirin is effective in only 50% of the patients infected with HCV genotype 1, and is associated with significant side effects. Therefore, it is still of importance to develop new drugs for treatment of HCV. Antiviral substan… Show more

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Cited by 65 publications
(61 citation statements)
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“…A fixed amount of the J6/JFH1-P47 strain of HCV genotype 2a [10,21], with a multiplication of infection (MOI) of 0.5 focus-forming units (ffu)/cell, was mixed with serial dilutions of the extracts (100, 30, 10, 1 and 0.1 μg/ml) and compounds (30, 10, 3, 1 and 0.1 μg/ml), and inoculated to the cells. After 2 h, the cells were washed with medium to remove the residual virus and further incubated in the medium containing the same concentrations of the test samples as those during virus inoculation.…”
Section: Analysis Of Anti-hcv Activitiesmentioning
confidence: 99%
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“…A fixed amount of the J6/JFH1-P47 strain of HCV genotype 2a [10,21], with a multiplication of infection (MOI) of 0.5 focus-forming units (ffu)/cell, was mixed with serial dilutions of the extracts (100, 30, 10, 1 and 0.1 μg/ml) and compounds (30, 10, 3, 1 and 0.1 μg/ml), and inoculated to the cells. After 2 h, the cells were washed with medium to remove the residual virus and further incubated in the medium containing the same concentrations of the test samples as those during virus inoculation.…”
Section: Analysis Of Anti-hcv Activitiesmentioning
confidence: 99%
“…Time-of-addition experiments were performed to assess the mode of action of the samples, as described previously [10][11][12]. In brief, three sets of experiments were done in parallel.…”
Section: Analysis Of Anti-hcv Activitiesmentioning
confidence: 99%
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“…The stock solutions were stored at −20°C until they were used. Analysis of anti-HCV method was described previously [9,13]. Huh-7.5 cells were seeded in 24-well plates (cell density 1.9×10 5 cells/well).…”
Section: Analysis Of Anti-hcv Activitiesmentioning
confidence: 99%
“…Moreover, some compounds have been isolated and tested for anti-HCV. Previous study reported that chalepin and pseudane IX which isolated from Ruta angustifolia leaves showed strong anti-HCV activities with 50% inhibitory concentration (IC 50 ) value of 1.7 ± 0.5 and 1.4 ± 0.2 µg/ml, respectively, without apparent cytotoxicity [9]. A major catabolite of chlorophyll A, which was isolated from Morinda citrifolia and identified as pheophorbide A, was reported to possess anti-HCV activity with IC 50 value of 0.3 µg/ml.…”
Section: Introductionmentioning
confidence: 99%