Antiviral activity and mechanism of action of arbidol against Hantaan virus infection

Xiong, Hairong; Zhang, Yihui; Deng, Kan; Liu, Qiang; Liu, Yuan-Yuan; Luo, Fan; Hou, Wanwan; Yang, Zhaoen

doi:10.4314/tjpr.v15i7.12

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…Arborol's enormous potential as a broad‐spectrum antiviral drug, as established in vitro and in vivo investigations, provides promise for its clinical application against a variety of infectious illnesses that are now untreatable. And arbidol also exerts anti‐inflammatory effects anti‐inflammatory activities against various types of viruses, such as influenza viruses, herpes simplex virus type II (HSV‐2) and hantavirus 31–33 . Here, we used a mouse‐adapted HCoV‐OC43 model with typical pulmonary disease symptoms and invested the effect of arbidol against HCoV‐OC43 infection.…”

Section: Introductionmentioning

confidence: 99%

“…And arbidol also exerts anti-inflammatory effects anti-inflammatory activities against various types of viruses, such as influenza viruses, herpes simplex virus type II (HSV-2) and hantavirus. [31][32][33] Here, we used a mouse-adapted HCoV-OC43 model with typical pulmonary disease symptoms and invested the effect of arbidol against HCoV-OC43 infection. Sucking mice were inoculated by injection of 10 000 LD 50 ( were both followed when performing animal experiments.…”

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confidence: 99%

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Arbidol increases the survival rate by mitigating inflammation in suckling mice infected with human coronavirus OC43 virus

Zhou,

Xie,

Qiu

et al. 2023

Journal of Medical Virology

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Human coronavirus OC43 (HCoV‐OC43) often causes common cold and is able to neuroinvasive, but it can also induce lower respiratory tract infections (LRTI) especially in children and the elderly adults with underlying diseases. HCoV‐OC43 infections currently have no approved antiviral treatment. Arbidol (ARB) is a broad‐spectrum antiviral and is an antiviral medication for the treatment of influenza used in Russia and China. Due to its multiple mechanisms of action, such as inhibition of viral fusion and entry, immunomodulation, and modulation of host cell signaling pathways, ARB has the potential to be an effective treatment option for viral infections. Therefore, the study aims to investigate the activities of ARB against HCoV‐OC43 infections. Suckling mice were infected with HCoV‐OC43 and treated with ARB (50, 25 and 12.5 mg/kg/d) by gavage once daily for 4 days. the survival rates and body weight were recorded, the viral titer was measured by real‐time quantitative polymerase chain reaction, cytokine levels were measured by Bio‐Plex assays. Histopathological changes of the lungs and brain were analyzed. Our results show ARB increased the survival rate, reduced viral copy numbers in the lung, mitigated pro‐inflammatory cytokine production, and improved brain and lung histopathology significantly without any significant toxicity or side effects in vivo. Our results suggest ARB could be a promising approach for the prevention and treatment of HCoV‐OC43 while further studies are needed to address these possibilities and the underlying mechanism.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Arbidol increases the survival rate by mitigating inflammation in suckling mice infected with human coronavirus OC43 virus

Zhou,

Xie,

Qiu

et al. 2023

Journal of Medical Virology

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New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (−)-fenchone hydrazonesv

Yarovaya

Kovaleva

Zaykovskaya

et al. 2021

Bioorganic & Medicinal Chemistry Letters

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Small molecules against viruses causing hemorrhagic fevers in Russia

Laev,

Yarovaya,

Salakhutdinov

2024

RUSS CHEM REV

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This review is devoted to small molecules (compounds with molecular weights of up to 800–900 Da) that show activity against viruses causing hemorrhagic fevers. Despite the wide occurrence of hemorrhagic fevers, effective medications for their prevention and treatment are virtually absent. Currently, the search for a new drug to fight these viruses is still a relevant task, since the synthetic nucleoside ribavirin used in clinical practice is not sufficiently effective. The review presents compounds that have antiviral action against the causative agents or alleviate symptoms of three acute infectious diseases occurring in Russia: Omsk hemorrhagic fever, Crimean-Congo hemorrhagic fever, and hemorrhagic fever with renal syndrome. The structures and activity parameters (half maximal inhibitory concentration) of the compounds are given and hypothesized mechanisms of their action are considered. The data published during the whole period of studies of these diseases are summarized. <br>The bibliography includes 160 references.

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Antiviral activity and mechanism of action of arbidol against Hantaan virus infection

Cited by 3 publications

References 17 publications

Arbidol increases the survival rate by mitigating inflammation in suckling mice infected with human coronavirus OC43 virus

Arbidol increases the survival rate by mitigating inflammation in suckling mice infected with human coronavirus OC43 virus

New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (−)-fenchone hydrazonesv

Small molecules against viruses causing hemorrhagic fevers in Russia

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