Antiviral activity and mode of action of a peptide isolated from Sorghum bicolor

Filho, Ivens Camargo; Cortez, Diógenes Aparı́cio Garcia; Ueda-Nakamura, Tânia; Nakamura, C. V.; Filho, Benedito Prado Dias

doi:10.1016/j.phymed.2007.07.059

Cited by 68 publications

(22 citation statements)

References 22 publications

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“…For example, phaseococcin and sesquin, two antimicrobial peptides isolated, respectively, from the seeds of runner beans (Phaseolus coccineus) and ground beans (Vigna sesquipedalis) are capable of inhibiting the reverse transcriptase activity of the HIV virus, thus hindering viral replication [65,66]. HSV-1 virucidal activity observed in a 2 kDa antiviral peptide isolated from Sorghum bicolor seeds may be explained by the capacity of the peptide to bind and mask essential viral envelope proteins [67]. In fact, modulation in the activity of enzymes involved in viral infection and replication appears to be one of the most prominent mechanisms utilized by plant peptides to inhibit viral proliferation [68].…”

Section: Avps Derived From Plantsmentioning

confidence: 99%

Antiviral peptides as promising therapeutic drugs

Boas

Campos

Berlanda

et al. 2019

Cell. Mol. Life Sci.

251

175

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While scientific advances have led to large-scale production and widespread distribution of vaccines and antiviral drugs, viruses still remain a major cause of human diseases today. The ever-increasing reports of viral resistance and the emergence and re-emergence of viral epidemics pressure the health and scientific community to constantly find novel molecules with antiviral potential. This search involves numerous different approaches, and the use of antimicrobial peptides has presented itself as an interesting alternative. Even though the number of antimicrobial peptides with antiviral activity is still low, they already show immense potential to become pharmaceutically available antiviral drugs. Such peptides can originate from natural sources, such as those isolated from mammals and from animal venoms, or from artificial sources, when bioinformatics tools are used. This review aims to shed some light on antimicrobial peptides with antiviral activities against human viruses and update the data about the already well-known peptides that are still undergoing studies, emphasizing the most promising ones that may become medicines for clinical use.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Section: Avps Derived From Plantsmentioning

confidence: 99%

Antiviral peptides as promising therapeutic drugs

Boas

Campos

Berlanda

et al. 2019

Cell. Mol. Life Sci.

251

175

View full text Add to dashboard Cite

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“…Alternatively, high kafirin may be extracted to make biodegradable plastic films similar to zeins (Buffo, Weller, & Gennadios, ; Da Silva & Taylor, ; Emmanbux, Stading, & Taylor, ; Gao et al., ; Taylor et al., ), potential use for the production of bakery products (Bean, Loerger, and Blackwell (); Bean, Loerger, Smith, and Blackwell (); Goodall, Campanella, Ejeta, & Hamaker, ; Schober, Bean, Tilley, Smith, & Loerger, ), antiviral (Camagro Filho, Cortez, Ueda‐Nakamura, Nkamura, & Dias Filho, ), and antihypertensive activities (Kamath, Niketh, Chandreshekar, & Rajini, ), and as excipient for pharmaceuticals (Elkhalifa, Georget, Barker, & Belton, ).…”

Section: Discussionmentioning

confidence: 99%

Composition, functional components, and physical characteristics of grain from staygreen and senescent sorghum lines grown under variable water availability

Emendack¹,

Burke²,

Bean

et al. 2018

Cereal Chem

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Background and objectives The inclusion of sorghum into human food and feed is limited by its low digestibility compared to corn, due to the presence of high total kafirin levels in sorghum grain. Water stress after pollination reduced grain filling, affecting the grain composition, grain functional components, and grain physical characteristics. Sorghum lines possessing the staygreen trait continue to fill their grain under postflowering water deficit. Understanding the environmental effect on the grain nutritional composition and grain physical characteristics of staygreen and senescent sorghum lines will be critical for breeders when selecting traits. This research evaluated a diverse group of staygreen and senescent sorghum lines subjected to full, preflowering water deficit, and postflowering water deficit irrigations. Findings Staygreen lines had significantly higher levels of total protein and total kafirin, but lower total starch than senescent types. Higher kafirin level was linked to kernel hardness, and this level increased under water deficit. There were no differences between staygreen and senescent sorghum lines in protein digestibility, fermentation efficiency, kafirin per percent protein, kernel hardness, kernel weight, and kernel diameter irrespective of irrigation treatment. Conclusions The nutritional quality and digestibility of sorghum grains were affected by the environment and varies across lines and cultivars. Higher total kafirin level in grains reduces digestibility and impedes energy utilization by interfering with starch digestion. Staygreen lines had significantly higher levels of total protein and total kafirin, but lower total starch than senescent types. Significance and novelty With considerable variability in grain digestibility and feeding value among sorghum cultivars, the effect of environments on grain nutritional composition and other quality traits should be considered to match the user's purpose.

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“…According to the literature, both macro and small molecules can exhibit a broad range of biological properties, among them, the antiviral activity (Camargo Filho et al 2008;Schmourlo et al 2005;Oevermann et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Plants from deer diet in the Brazilian Pantanal Wetland as potential source of antiviral and antioxidant compounds

Simoni

Fernandes²,

Camargo³

et al. 2014

VR&R

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The major part of plants foraged by endangered pampas and marsh deer at the Brazilian Pantanal Wetland belongs to botanical genera containing medicinal species used mainly for healing infectious and inflammatory diseases. In this study, extracts and fractions of 19 plant species from deer diet were in vitro screened against bovine and suid herpesviruses, avian reovirus and infectious bursal disease virus (IBDV). At non-cytotoxicity concentrations, the extract and/or fractions from 14 plant species presented antiviral activity against at least one of these viruses except IBDV. Cecropia pachystachya, Melochia villosa and Polygonum acuminatum presented the most relevant results against bovine and suid herpesviruses while Andira cuyabensis was the most active plant against avian reovirus. C. pachystachya extract and fractions showed virucide effect, and kept their inhibitory activity towards both herpesviruses independent of the addition time in cell culture. Considering the benefit of the antioxidant activity of food and medicinal plants for the health balance, and its important role in viral infections, the extracts were also screened in a DPPH assay. Our findings show that several plants foraged by pampas and marsh deer possess antiviral activity against some pathogenic viruses for mammals. This study proposed an innovative strategy by adopting plants consumed in the diet of wild non-primate mammals for the search of potentially therapeutic substances.

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Antiviral activity and mode of action of a peptide isolated from Sorghum bicolor

Cited by 68 publications

References 22 publications

Antiviral peptides as promising therapeutic drugs

Antiviral peptides as promising therapeutic drugs

Composition, functional components, and physical characteristics of grain from staygreen and senescent sorghum lines grown under variable water availability

Plants from deer diet in the Brazilian Pantanal Wetland as potential source of antiviral and antioxidant compounds

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