Antiviral activity and underlying mechanisms of baicalin against avian infectious bronchitis virus <i>in vitro</i>

Feng, Haipeng; Zhang, Kai; Zhang, Kang; Guo, Zhuang; Liu, Qin; Wang, Lei; Wang, Xuezhi; Qiu, Zhengying; Wang, Guibo; Zhang, Jingyan; Li, Jianxi

doi:10.1080/03079457.2022.2109453

Cited by 9 publications

(3 citation statements)

References 42 publications

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“…Throughout the infection period (days at [13][14][15][16][17][18], the weight gain in IBV-infected broilers was notably slower than the control group. Broilers exhibited a range of clinical signs upon being challenged with IBV, including ruffled feathers, neurological signs, clustering and gathering behaviour, and wing drooping.…”

Section: Observation Of Clinical Signs and Follow Up Of The Changes I...mentioning

confidence: 89%

“…The anti-inflammatory properties of Bai and its low toxicity make it an interesting compound for the potential treatment of viral respiratory tract diseases [11,12]. Our previous findings indicate that Bai significantly inhibited the replication of the IBV Beaudette strain in Vero cells [13]. Despite the positive effect of Bai on respiratory tract microbiota, its potential antiviral effect has not been assessed in chickens.…”

Section: Introductionmentioning

confidence: 99%

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Baicalin Protects Broilers against Avian Coronavirus Infection via Regulating Respiratory Tract Microbiota and Amino Acid Metabolism

Feng,

Zhang,

Wang

et al. 2024

IJMS

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An increasing amount of evidence indicates that Baicalin (Bai, a natural glycosyloxyflavone compound) exhibits an antiviral effect against avian viruses. However, it remains unclear if the antiviral effect of Bai against infectious bronchitis virus (IBV) is exerted indirectly by modulating respiratory tract microbiota and/or their metabolites. In this study, we investigated the protection efficacy of Bai in protecting cell cultures and broilers from IBV infection and assessed modulation of respiratory tract microbiota and metabolites during infection. Bai was administered orally to broilers by being mixed in with drinking water for seven days. Ultimately, broilers were challenged with live IBV. The results showed that Bai treatment reduced respiratory tract symptoms, improved weight gain, slowed histopathological damage, reduced virus loads and decreased pro-inflammation cytokines production. Western blot analysis demonstrated that Bai treatment significantly inhibited Toll-like receptor 7 (TLR7), myeloid differentiation factor 88 (MyD88) and nuclear factor kappa-B (NF-κB) expression both in cell culture and cells of the trachea. Bai treatment reversed respiratory tract microbiota dysbiosis, as shown by 16S rDNA sequencing in the group of broilers inoculated with IBV. Indeed, we observed a decrease in Proteobacteria abundance and an increase in Firmicutes abundance. Metabolomics results suggest that the pentose phosphate pathway, amino acid and nicotinamide metabolism are linked to the protection conferred by Bai against IBV infection. In conclusion, these results indicated that further assessment of anti-IBV strategies based on Bai would likely result in the development of antiviral molecule(s) which can be administered by being mixed with feed or water.

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Section: Observation Of Clinical Signs and Follow Up Of The Changes I...mentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Baicalin Protects Broilers against Avian Coronavirus Infection via Regulating Respiratory Tract Microbiota and Amino Acid Metabolism

Feng,

Zhang,

Wang

et al. 2024

IJMS

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“…SBG, a flowering plant belonging to the Lamiaceae family, is widely distributed in China, Korea, Japan, Mongolia, and Russia [14]. Many scientific studies have demonstrated a wide range of pharmacological effects of SBG, including anti-inflammatory [84,85], antiviral [86], antibacterial [87], antioxidant [88], anticancer [89,90], and immunomodulatory activities [86]. The root of SBG, designated Scutellariae Radix or Huang Qin, is one of the most popular herbal medicines in China.…”

Section: Sbgmentioning

confidence: 99%

Therapeutic Potential of Bioactive Components from Scutellaria baicalensis Georgi in Inflammatory Bowel Disease and Colorectal Cancer: A Review

Jang

Kim

2023

IJMS

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Scutellaria baicalensis Georgi (SBG), an herbal medicine with various biological activities, including anti-inflammatory, anticancer, antiviral, antibacterial, and antioxidant activities, is effective in treatment of colitis, hepatitis, pneumonia, respiratory infections, and allergic diseases. This herbal medicine consists of major active substances, such as baicalin, baicalein, wogonoside, and wogonin. Inflammatory bowel disease (IBD) comprises a group of inflammatory conditions of the colon and small intestine, with Crohn’s disease and ulcerative colitis being the main types. IBD can lead to serious complications, such as increased risk of colorectal cancer (CRC), one of the most common cancers worldwide. Currently, there is no cure for IBD, and its incidence has been increasing over the past few decades. This review comprehensively summarizes the efficacy of SBG in IBD and CRC and may serve as a reference for future research and development of drugs for IBD and cancer treatment.

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Baicalin, a promising therapeutic drug against tilapia lake virus (TiLV) infection

Tu,

Leng,

Zhang

et al. 2025

Aquaculture

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Antiviral activity and underlying mechanisms of baicalin against avian infectious bronchitis virus in vitro

Cited by 9 publications

References 42 publications

Baicalin Protects Broilers against Avian Coronavirus Infection via Regulating Respiratory Tract Microbiota and Amino Acid Metabolism

Baicalin Protects Broilers against Avian Coronavirus Infection via Regulating Respiratory Tract Microbiota and Amino Acid Metabolism

Therapeutic Potential of Bioactive Components from Scutellaria baicalensis Georgi in Inflammatory Bowel Disease and Colorectal Cancer: A Review

Baicalin, a promising therapeutic drug against tilapia lake virus (TiLV) infection

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