Antiviral Activity of a Hot Water Extract of Black Soybean against a Human Respiratory Illness Virus

Yamai, Masafumi; Tsumura, Kazunori; Kimura, M.; Fukuda, Seiji; Murakami, Tsukasa; Kimura, Yoshinobu

doi:10.1271/bbb.67.1071

Cited by 34 publications

(13 citation statements)

References 21 publications

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“…A previous study also showed an isolated monomeric protein (molecular mass of 25 kDa), containing N-terminal sequence, which resembles a segment of chitin synthase. The protein, named glysojanin, demonstrated a potent antifungal activity against Fusarium oxysporum and Mycosphaerella arachidicola and antiviral potential against HIV-1, human adenovirus type 1 and coxsackievirus B1 [98,120]. …”

Section: Health Benefits Of Anthocyanins Rich Bsbmentioning

confidence: 99%

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

2017

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Polyphenols are plant secondary metabolites containing antioxidant properties, which help to protect chronic diseases from free radical damage. Dietary polyphenols are the subject of enhancing scientific interest due to their possible beneficial effects on human health. In the last two decades, there has been more interest in the potential health benefits of dietary polyphenols as antioxidant. Black soybeans (Glycine max L. Merr) are merely a black variety of soybean containing a variety of phytochemicals. These phytochemicals in black soybean (BSB) are potentially effective in human health, including cancer, diabetes, cardiovascular diseases, cerebrovascular diseases, and neurodegenerative diseases. Taking into account exploratory study, the present review aims to provide up-to-date data on health benefit of BSB, which helps to explore their therapeutic values for future clinical settings. All data of in vitro and in vivo studies of BSB and its impact on human health were collected from a library database and electronic search (Science Direct, PubMed, and Google Scholar). The different pharmacological information was gathered and orchestrated in a suitable spot on the paper.

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Section: Health Benefits Of Anthocyanins Rich Bsbmentioning

confidence: 99%

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

2017

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“…On urinalysis, elevated K was noted in females high content of K in black soybean extract, and therefore Black soybean extract has been used as a folk medicine (Hayashi 1998;Yamai, 2001) and hot water extracts are known to enhance ciliary activity, with transport of mucous towards the pharynx (Yamai, 2001), as well as significant antiviral activity (Yamai et al, 2003). Although we paid especial attention to airway cells, particularly ciliated epithelial cells in the larynx and trachea, no histopathological alterations were noted.…”

Section: Discussionmentioning

confidence: 99%

A twenty eight-day repeated dose toxicity study of black soybean extract in Sprague-Dawley rats

Hagiwara¹,

Imai²,

Numano³

et al. 2010

J. Toxicol. Sci.

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“…Various investigators have recently evaluated extracts that purportedly have activity against respiratory disease caused by CVB. Extracts that were tested included hot water extracts of black soybean [99], alcohol extracts of Loranthus yadoriki [100], garlic and Shanghuanglian [101], Xinjierkang granules [100], acetate extract of Tian-hua-fen 102], Chuan-Kang-Ping granules [103] and various extracts of Ganlu Xiaodu Dan [104]. The black, soybean extract was found to be a broad-spectrum virus inhibitor and inhibited CVB1 with an IC50 ~ 2.6 µg/ml which was below the CC50 value.…”

Section: Natural Productsmentioning

confidence: 99%

“…The Xinjierkang granules extract were apparently evaluated for efficacy in a mouse myocarditis model for CVB. The compound seemed to reduce death due to virus [99]. These types of products need to be further purified to ascertain the compound(s) within the extract responsible for the antiviral activity detected in the studies mentioned above.…”

Section: Natural Productsmentioning

confidence: 99%

Current Status of Anti-Picornavirus Therapies

Barnard

2006

CPD

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Picornaviruses are important human pathogens causing severe morbidity and some mortality with the potential to cause worldwide crippling disease. Currently, there are few treatments for many of the viruses in the Picornaviridae, For rhinoviruses, there are no approved treatments, although ruprintrivir looks promising in clinical trials and pyridazinyl oxime ethers may prove useful. Poliovirus treatments are needed to supplement the World Health Organization's polio eradication plan in order to treat infections caused by reversion of the attenuated vaccine virus and to supplement vaccine coverage control in polio endemic areas. However, no promising compounds for treatment of poliovirus have been developed due to the efficacy of the vaccines in use. Broad-spectrum inhibitors developed for other picornavirus may be useful for poliovirus infections. Coxsackievirus infections in children and in infants are being treated with pleconaril with some efficacy in reducing mortality and improving recovery, albeit the treatment is often on a compassionate use basis. There are no therapies for echovirus infections. Very little drug discovery research is being done to develop inhibitors for echovirus infections, probably due to the broad-spectrum inhibition exhibited by capsid binding agents and protease inhibitors discovered for treatment of other picornaviruses. For example, pyridazinyl oxime ethers are inhibitory to most echoviruses. Treatments for enterovirus infections are also limited, although in a small clinical trial, milrinone seemed to reduce mortality and improve recovery from EV71-induced pulmonary edema. Thus, these results strongly emphasize the need for the development of potent and nontoxic compounds for the treatment of picornavirus infections.

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Antiviral Activity of a Hot Water Extract of Black Soybean against a Human Respiratory Illness Virus

Cited by 34 publications

References 21 publications

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

A twenty eight-day repeated dose toxicity study of black soybean extract in Sprague-Dawley rats

Current Status of Anti-Picornavirus Therapies

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