Antiviral activity of Bifidobacterium longum SPM1205, 1206 and Lactobacillus ruminis SPM0211 against rotavirus

Abstract

Rotavirus is the most common cause of severe gastroenteritis and dehydrating diarrhea in infants and young children worldwide. Currently, rotavirus vaccines have shown good tolerance and significant efficacy. However, these vaccines are limits and restrictions. Probiotic bacteria, such as Lactobacillus spp. and Bifidobacterium spp. is reported the multiple potential health effects including blocking gastroenteric pathogens, enhancing the immune response and antiviral effects. The aim of this study was to assess the antiviral activity of 3 Lactobacillus spp. and 14 Bifidobacterium spp. isolated from healthy Korean against rotavirus. In this study, we evaluated the in vitro antiviral activity of these probiotics against rotavirus by plaque assay. All of them were not toxic to vero and caco‐2 cells. B. longum SPM1205, 1206 and L. ruminis SPM 0211 have shown significant antiviral activity against rotavirus compared to control group. These results suggest that B. longum SPM1205, 1206 and L. ruminis SPM0211 are potential new therapeutic tool against rotavirus.