Antiviral Activity of Compounds Isolated From Plants

Pérez, Rocío Silva

doi:10.1076/phbi.41.2.107.14240

Cited by 78 publications

(55 citation statements)

References 106 publications

(114 reference statements)

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“…Phenolic compound have antimicrobial (Taguri et al 2006), antimutagenic, (Lairon and Amiot 1999), antiviral (Perez 2003), anticarcinogenic (Aaby et al 2004), anti-inflammatory (Dos Santos et al 2006), antiproliferative and vasodilatory actions (Lule and Xia 2005) and have potential preventive properties against cardiovascular diseases, hormonal related cancers (Gupta and Abu-Ghannam 2012). In addition, to their antioxidant properties, isoflavones and lignans exert a weak oestrogenic activity (Barnes et al 2000), which may be implicated in several mechanisms protecting the human body and also have been suggested to reduce the risks of cancer and to lower serum cholesterol (Barnes et al 2000).…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Horse gram- an underutilized nutraceutical pulse crop: a review

Prasad

Singh

2014

J Food Sci Technol

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Horse gram is an underutilized pulse crop grown in wide range of adverse climatic conditions. It occupies an important place in human nutrition and has rich source of protein, minerals, and vitamins. Besides nutritional importance, it has been linked to reduced risk of various diseases due to presence of non-nutritive bioactive substances. These bioactive substances such as phytic acid, phenolic acid, fiber, enzymatic/proteinase inhibitors have significant metabolic and/or physiological effects. The importance of horse gram was well recognized by the folk/alternative/traditional medicine as a potential therapeutic agent to treat kidney stones, urinary diseases, piles, common cold, throat infection, fever etc. The inception of nutraceutical concept and increasing health consciousness the demand of nutraceutical and functional food is increased. In recent years, isolation and utilization of potential antioxidants from legumes including horse gram are increased as it decreases the risk of intestinal diseases, diabetes, coronary heart disease, prevention of dental caries etc. Keeping in view the increasing demand of food having nutraceutical values, the present review ascribed with recent scientific knowledge towards the possibilities of exploring the horse gram, as a source of food and nutraceuticals compounds.

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Section: Phenolic Compoundsmentioning

confidence: 99%

Horse gram- an underutilized nutraceutical pulse crop: a review

Prasad

Singh

2014

J Food Sci Technol

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“…The result of the enzyme inhibition assay showed that all seven standard compounds exhibited anti-influenza virus activity, and pentagalloylglucose, benzoylpaeoniflorin, albiflorin and paeoniflorin showed stronger activity against NA than Oseltamivir acid. In several literature reports [28][29][30], the antiviral activities of pentagalloylglucose and gallic acid have been reported, but there are few reports regarding the antiviral activities of methyl gallate, ethyl gallate, benzoylpaeoniflorin, albiflorin and paeoniflorin. In this study, the NA inhibitory activity of methyl gallate, ethyl gallate, benzoylpaeoniflorin, albiflorin and paeoniflorin were reported for the first time.…”

Section: Chemicals and Standard Substancesmentioning

confidence: 99%

Anti-Influenza Virus Activity and Constituents Characterization of Paeonia delavayi Extracts

Yang

Huang

2016

Molecules

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Paeonia delavayi, an endemic species in southwestern China, has been widely used as a traditional remedy for cardiovascular, extravasated blood, stagnated blood and female diseases in traditional Chinese medicine (TCM). However, there are no reports on the anti-influenza virus activity of this species. Here, the anti-influenza virus activity of P. delavayi root extracts was first evaluated by an influenza virus neuraminidase (NA) inhibition assay. Meantime, constituents in the active extracts were identified using ultra-high performance liquid coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) and seven major identified constituents were used to further evaluate the NA inhibitory activity. The results showed that the ethyl acetate fraction (EA) and the ethanol fraction (E) of P. delavayi both presented strong NA inhibitory activity with IC 50 values of 75.932 µg/mL and 83.550 µg/mL, respectively. Twenty-seven constituents were characterized in these two active extracts by UPLC-Q-TOF-MS analysis, and seven major identified constituents exhibited high activity against the influenza virus.Among them, Benzoylpaeoniflorin (IC 50 = 143.701 µM) and pentagalloylglucose (IC 50 = 62.671 µM) exhibited the highest activity against the influenza virus, even far stronger than oseltamivir acid (IC 50 = 281.308 µM). This study indicated that P. delavayi was a strong NA inhibitor, but cell-based inhibition, anti-influenza virus activity in vivo and anti-influenza virus mechanism still need to be tested and explored.

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“…Baillon is a deciduous, woody stem liana from the Schisandraceae family, which belongs to primitive dicotyledon plants with undifferentiated embryos. This compounds display significant antioxidant action and some of them were identified as potent anti-human immunodeficiency virus agent (Perez 2003). Schisandra chinensis contains dibenzo- [a,c]cyclooctadiene lignans that are unique natural substances.…”

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confidence: 99%

Somatic embryogenesis from zygotic embryos of Schisandra chinensis

Smíšková¹,

Vlašínová²,

Havel³

2005

Biologia plant.

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We describe the multi-step regeneration system of medicinal plant Schisandra chinensis (Turcz.) Baill. The seeds were pre-treated with 0.005 µM thidiazuron. Subsequently the zygotic embryos of the early heart stage were cultured on medium with 50 µM of 2,4-dichlorophenoxyacetic acid (2,4-D) and after three weeks the embryogenic calli were transferred to a medium with 10 µM of 2,4-D and 4 µM of 6-benzyladenine and were sub-cultured at the 4-week intervals. Abscisic acid (30 µM) and polyethyleneglycol (3 %) significantly influenced the synchronization of development of the somatic embryos (SEs) to the globular stage. The following culture on a medium without growth regulators resulted in full developed cotyledonary stage SEs. Indole-3-butyric acid (0.05 µM) contributed to their rapid conversion to plantlets.

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Antiviral Activity of Compounds Isolated From Plants

Abstract: This review presents 344 compounds isolated and identified from plants that previously demostrated antiviral activity. These compounds have been classified in appropiate chemical groups and data are reported on their pharmacological effect, mechanism of action, and other properties.

Cited by 78 publications

References 106 publications

Horse gram- an underutilized nutraceutical pulse crop: a review

Horse gram- an underutilized nutraceutical pulse crop: a review

Anti-Influenza Virus Activity and Constituents Characterization of Paeonia delavayi Extracts

Somatic embryogenesis from zygotic embryos of Schisandra chinensis

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