Antiviral activity of famciclovir and acyclovir in mice infected intraperitoneally with herpes simplex virus type 1 SC16

Ashton, R.; Abbott, K. H.; Smith, G. M.; Sutton, David

doi:10.1093/jac/34.2.287

Cited by 11 publications

(3 citation statements)

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“…This was fll'St suggested by Larsson et al (1986), Datema et al (1987) and Boyd et al (1987). More recent experiments in murine models for systemic HSV infection provided further weight for this hypothesis (Boyd et al, 1988;Sutton & Boyd, 1993;Ashton et al, 1994). Several workers have reported an effect of PCV in tissue culture that appeared to persist for up to several days after removal of the drug (Weinberg et al, 1992;Bacon & Schinazi, 1993;Standring-Cox et al, 1994;Bacon & Howard, 1996).…”

Section: Discussionmentioning

confidence: 93%

The Influence of Cyclosporin Immunosuppression on the Efficacy of Famciclovir or Valaciclovir Chemotherapy Studied in a Murine Herpes Simplex Virus Type 1 Infection Model

Thackray

Field

1997

Antivir Chem Chemother

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Mice with or without immunosuppression by cyclosporin (Cy) were inoculated with herpes simplexvirus type 1 in the ear pinna. Without immunosuppression, 20% of the mice died; clinical signs resolved in survivors and infectious viruswas cleared by 7 to 10 days post-inoculation (p.i.). With Cy, mortality was 50%, clinical signs increased and infectious virus persisted. Mice were treated with either valaciclovir (VACV) or famciclovir (FCV) from days 1-50r 5-10 p.i. and both compounds moderated the disease, but only FCV led to rapid restoration of body weight ond complete protection from mortality. Resolution of clinical signs was more marked with immunosuppression. On cessation of VACV theropy, infectious virus recurred on individual days. Without immunosuppression, recurrence was detected in neural tissues only, but with Cy, infectious virus also recurred in skin. No recurrences of infectious virus were observed in any FCV-treated mice.

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Section: Discussionmentioning

confidence: 93%

The Influence of Cyclosporin Immunosuppression on the Efficacy of Famciclovir or Valaciclovir Chemotherapy Studied in a Murine Herpes Simplex Virus Type 1 Infection Model

Thackray

Field

1997

Antivir Chem Chemother

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“…21,22 Famciclovir is more effective than aciclovir in preventing virus replication. 23 In vitro, famciclovir has a two-to 50-fold stronger and more prolonged intracellular half-life compared with aciclovir. 24 Moreover, famciclovir treatment decreased mortality and prolonged survival in HSV-1-infected mice.…”

Section: Discussionmentioning

confidence: 99%

“…Famciclovir is more effective than aciclovir in preventing virus replication 23 . In vitro , famciclovir has a two‐ to 50‐fold stronger and more prolonged intracellular half‐life compared with aciclovir 24 .…”

Section: Discussionmentioning

confidence: 99%

Experimental studies on the antiviral agent famciclovir in Behcet's disease symptoms in ICR mice

Sohn

Bang

et al. 2001

Br J Dermatol

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SummaryBackground Chronic oral aphthae, recurrent genital ulcers and uveitis are the three main manifestations of Behc Ëet's disease (BD). The aetiopathogenesis of BD is still obscure, but herpes simplex virus (HSV) is one of the possible causal factors. Various kinds of drugs, including immunosuppressants and aciclovir have been used in treatment, but effectiveness is variable. Objectives To demonstrate the efficacy of famciclovir, an antiviral compound that acts against HSV, varicella-zoster virus and hepatitis B virus, in a murine model of BD. Methods Using the HSV-induced BD mouse model, famciclovir was administered variously before and after inoculation or from the day of lesion occurrence, with appropriate controls. Ulceration of the mouth and genital skin and eye involvement were monitored. In addition, spleen cytokine expression was measured by polymerase chain reaction. Results Pretreatment and concurrent treatment did not affect the occurrence of BD, but treatment from the appearance of lesions was effective in improving BD and preventing recurrence. After famciclovir, interleukin 2 expression correlated with the recurrence of BD symptoms. Conclusions This model suggests the possible role of immune response to viral infection in the development and activation of BD. The study provides a rationale for clinical trials of famciclovir in the human form of BD.

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Famciclovir

Jarvest¹,

Sutton²,

Hodge³

2002

Pharmaceutical Biotechnology

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Antiviral activity of famciclovir and acyclovir in mice infected intraperitoneally with herpes simplex virus type 1 SC16

Cited by 11 publications

References 0 publications

The Influence of Cyclosporin Immunosuppression on the Efficacy of Famciclovir or Valaciclovir Chemotherapy Studied in a Murine Herpes Simplex Virus Type 1 Infection Model

The Influence of Cyclosporin Immunosuppression on the Efficacy of Famciclovir or Valaciclovir Chemotherapy Studied in a Murine Herpes Simplex Virus Type 1 Infection Model

Experimental studies on the antiviral agent famciclovir in Behcet's disease symptoms in ICR mice

Famciclovir

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