Antiviral Activity of Graphene Oxide: How Sharp Edged Structure and Charge Matter

Ye, Shiyi; Shao, Kang; Li, Zhonghua; Guo, Nan; Zuo, Yunpeng; Li, Qin; Lü, Zhicheng; Chen, Lu; He, Qigai; Han, Heyou

doi:10.1021/acsami.5b06876

Cited by 316 publications

(337 citation statements)

References 60 publications

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“…In spite of the graphene oxide, microscopy studies show that morphology of virions does not change upon interactions with the functionalized graphene sheets. To obtain further evidence for the potential of suitably functionalized graphene sheets to bind viruses, in vitro assays were carried out.…”

Section: Resultsmentioning

confidence: 99%

“…Graphene is a single‐atom thick 2D carbon allotrope with both, high structural stability and flexibility at the same time. Its large surface area and unique physicochemical properties make it very interesting for biomedical applications, such as detection and incapacitation of different types of pathogens . Inspired by multivalent heparan sulfate mimetic nanomaterials, such as sulfated gold nanoparticles or graphene oxide, polysulfated graphene could be considered as a bioactive surface for multivalent interactions with biological structures, such as viruses.…”

Section: Introductionmentioning

confidence: 99%

“…However, only a mechanistic study of nanomaterials at the biointerface with pathogens can provide insight into the molecular and quantitative relations, which allows one to control their interactions by fine tuning the structural parameters. While a correlation between thicknesses, lateral size, and surface structure of graphene derivatives and their antibacterial activity was reported, less attention has been paid to their surface modification and functionality . Since an appropriate functionality is inevitable for a selective targeting of biological structures in a complex environment, an investigation of this parameter is highly relevant for designing graphene‐based bioactive surfaces with specific binding properties that would lead to antiviral or viral delivery systems.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Functionalized Graphene as Extracellular Matrix Mimics: Toward Well‐Defined 2D Nanomaterials for Multivalent Virus Interactions

Gholami

Lauster

Ludwig

et al. 2017

Adv Funct Materials

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Polysulfated nanomaterials that mimic the extracellular cell matrix are of great interest for their potential to modulate cellular responses and to bind and neutralize pathogens. However, control over the density of active functional groups on such biomimetics is essential for efficient interactions, and this remains a challenge. In this regard, producing polysulfated graphene derivatives with control over their functionality is an intriguing accomplishment in order to obtain highly effective 2D platforms for pathogen interactions. Here, a facile and efficient method for the controlled attachment of a heparin sulfate mimic on the surface of graphene is reported. Dichlorotriazine groups are conjugated to the surface of graphene by a one-pot [2+1] nitrene cycloaddition reaction at ambient conditions, providing derivatives with defined functionality. Consecutive step by step conjugation of hyperbranched polyglycerol to the dichlorotriazine groups and eventual conversion to the polyglycerol sulfate result in the graphene based heparin biomimetics. Scanning force microscopy, cryo-transmission electron microscopy, and in vitro bioassays reveal strong interactions between the functionalized graphene (thoroughly covered by a sulfated polymer) and vesicular stomatitis virus. Infection experiments with highly sulfated versions of graphene drastically promote the infection process, leading to higher viral titers compared to nonsulfated analogues.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Functionalized Graphene as Extracellular Matrix Mimics: Toward Well‐Defined 2D Nanomaterials for Multivalent Virus Interactions

Gholami

Lauster

Ludwig

et al. 2017

Adv Funct Materials

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“…Experimental studies have shown that the interaction between graphene-family 2D materials and bacteria, viruses as well as fungi could lead to strong antibacterial, 267–270, 276 antiviral 272, 273 and antifungal 268, 274, 275 activities. For example, the antibacterial activity of graphene and GO sheets might be attributed to damage on bacterial membranes induced by the atomically sharp edges of the 2D sheets as demonstrated in Fig.…”

Section: Fundamental Modes Of Biological Interactionmentioning

confidence: 99%

Biological and environmental interactions of emerging two-dimensional nanomaterials

Wang¹,

Zhu²,

Qiu³

et al. 2016

Chem. Soc. Rev.

239

210

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Two-dimensional materials have become a major focus in materials chemistry research worldwide with substantial efforts centered on synthesis, property characterization, and technological application. These high-aspect ratio sheet-like solids come in a wide array of chemical compositions, crystal phases, and physical forms, and are anticipated to enable a host of future technologies in areas that include electronics, sensors, coatings, barriers, energy storage and conversion, and biomedicine. A parallel effort has begun to understand the biological and environmental interactions of synthetic nanosheets, both to enable the biomedical developments and to ensure human health and safety for all application fields. This review covers the most recent literature on the biological responses to 2D materials and also draws from older literature on natural lamellar minerals to provide additional insight into the essential chemical behaviors. The article proposes a framework for more systematic investigation of biological behavior in the future, rooted in fundamental materials chemistry and physics. That framework considers three fundamental interaction modes: (i) chemical interactions and phase transformations, (ii) electronic and surface redox interactions, and (iii) physical and mechanical interactions that are unique to near-atomically-thin, high-aspect-ratio solids. Two-dimensional materials are shown to exhibit a wide range of behaviors, which reflect the diversity in their chemical compositions, and many are expected to undergo reactive dissolution processes that will be key to understanding their behaviors and interpreting biological response data. The review concludes with a series of recommendations for high-priority research subtopics at the “bio-nanosheet” interface that we hope will enable safe and successful development of technologies related to two-dimensional nanomaterials.

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“…In some other studies, it was reported that the negative charges on GO and rGO along with their unique single‐layer structure were enough to bind and thus suppress the infection of the pseudorabies virus (PRV, a DNA virus) and porcine epidemic diarrhea virus (PEDV, an RNA virus) . Comparison experiments confirmed that both the negative charges and nanosheet structure contributed to their antiviral ability . It was further shown that heat treatment could enhance virus capture and even denaturation due to the excellent heat and electron transfer properties of GO or rGO …”

Section: Interactions Between Graphene Derivatives and Pathogensmentioning

confidence: 89%

Multivalent Interactions between 2D Nanomaterials and Biointerfaces

et al. 2018

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2D nanomaterials, particularly graphene, offer many fascinating physicochemical properties that have generated exciting visions of future biological applications. In order to capitalize on the potential of 2D nanomaterials in this field, a full understanding of their interactions with biointerfaces is crucial. The uptake pathways, toxicity, long-term fate of 2D nanomaterials in biological systems, and their interactions with the living systems are fundamental questions that must be understood. Here, the latest progress is summarized, with a focus on pathogen, mammalian cell, and tissue interactions. The cellular uptake pathways of graphene derivatives will be discussed, along with health risks, and interactions with membranes-including bacteria and viruses-and the role of chemical structure and modifications. Other novel 2D nanomaterials with potential biomedical applications, such as transition-metal dichalcogenides, transition-metal oxide, and black phosphorus will be discussed at the end of this review.

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Antiviral Activity of Graphene Oxide: How Sharp Edged Structure and Charge Matter

Cited by 316 publications

References 60 publications

Functionalized Graphene as Extracellular Matrix Mimics: Toward Well‐Defined 2D Nanomaterials for Multivalent Virus Interactions

Functionalized Graphene as Extracellular Matrix Mimics: Toward Well‐Defined 2D Nanomaterials for Multivalent Virus Interactions

Biological and environmental interactions of emerging two-dimensional nanomaterials

Multivalent Interactions between 2D Nanomaterials and Biointerfaces

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