Antiviral activity of green tea catechins against feline calicivirus as a surrogate for norovirus

Oh, Eun-Gyoung; Kim, Kyoung-Lan; Shin, Soon Bum; Son, Kwang Tae; Lee, Hee-Jung; Kim, Tae Hoon; Kim, Young‐Mog; Cho, Eun-Ji; Kim, Do-Kyun; Lee, Eun Woo; Lee, Myung-Suk; Shin, Il‐Shik; Kim, Ji Hoe

doi:10.1007/s10068-013-0119-4

Cited by 34 publications

(23 citation statements)

References 20 publications

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“…This discrepancy may be a result of differences in the raw materials used in terms of harvest season and location, as described above (Kulanthaiyesu and Sadaiyappa, 2012). In addition, the SI of Phaeophyta extracts were similar to those of territorial plant extracts (with the exception of Camelia sinensis), ranging from 0.53 to 6.29 (Oh et al, 2013).…”

Section: Antiviral Assaymentioning

confidence: 69%

“…This difference may be due to harvesting during a different season or the different origin of the raw materials (Arunkmar and Sivakumar, 2012). Interestingly, the cytotoxicity of Phaeophyta extracts against CRFK cells was higher than that of territorial plant extracts, including those of Allium scorodorpasum, Capsicum annuum, Hovenia dulcis, and Citrus aurantium (Kim et al, 2009;Oh et al, 2013), suggesting that the Phaeophyta extracts exert a more negative effect on cell adherence and growth compared with extracts of medicinal herbs and spices.…”

Section: Antiviral Assaymentioning

confidence: 99%

“…The SI indicates the efficacy of antiviral activity. A higher SI means greater antiviral activity with low cellular toxicity, as well as higher commercialization potential (Oh et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Phaeophyta Extracts Exhibit Antiviral Activity against Feline Calicivirus

Youngik¹,

Kim²,

Moon³

et al. 2014

Fisheries and aquatic sciences

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The objective of this study was to evaluate the antiviral activity of Phaeophyta extracts against feline calicivirus (FCV), used as a norovirus surrogate. A bioassay-guided cytotoxicity and virus infectivity assay revealed that methanolic extracts of Phaeophyta possessed significant antiviral activity against FCV. Among them, Eisenia bicyclis extract exhibited the highest antiviral activity against FCV. The 50% effective concentration of the extract (EC 50 ) inhibiting FCV viral replication by 50% was 80 µg/ mL. The extract also showed the highest selectivity index, calculated from the ratio of the median cellular cytotoxicity concentration (CC 50 ) and EC 50 , indicating antiviral efficacy against FCV. In addition, significant interruption of FCV infection was observed by pretreatment of host Crandall-Reese feline kidney cells with the E. bicyclis extract (200 µg/mL) prior to virus infection, in a dosedependent manner.

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Section: Antiviral Assaymentioning

confidence: 69%

Section: Antiviral Assaymentioning

confidence: 99%

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Phaeophyta Extracts Exhibit Antiviral Activity against Feline Calicivirus

Youngik¹,

Kim²,

Moon³

et al. 2014

Fisheries and aquatic sciences

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“…18,19 Although catechins and theaflavins have been reported to be equally effective antioxidants, 18 there was a difference in anti-calicivirus activity (Table 1). It was reported by Oh et al 20 that a much higher concentration of EGCG (50% effective concentration (EC 50 ) = 12 mg ml − 1 , about 26 mM calculated from the MW of EGCG) showed antiviral activity against FCV.…”

Section: Discovery Of Anti-calicivirus Compoundsmentioning

confidence: 99%

Antiviral effect of theaflavins against caliciviruses

et al. 2016

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Caliciviruses are contagious pathogens of humans and various animals. They are the most common cause of viral gastroenteritis in humans, and can cause lethal diseases in domestic animals such as cats, rabbits and immunocompromised mice. In this study, we conducted cytopathic effect-based screening of 2080 selected compounds from our in-house library to find antiviral compounds against three culturable caliciviruses: feline calicivirus, murine norovirus (MNV) and porcine sapovirus (PoSaV). We identified active six compounds, of which two compounds, both related to theaflavins, showed broad antiviral activities against all three caliciviruses; three compounds (abamectin, a mixture of avermectin B1a and B1b; avermectin B1a; and (− )-epigallocatechin gallate hydrate) were effective against PoSaV only; and a heterocyclic carboxamide derivative (BFTC) specifically inhibited MNV infectivity in cell cultures. Further studies of the antiviral mechanism and structure-activity relationship of theaflavins suggested the following: (1) theaflavins worked before the viral entry step; (2) the effect of theaflavins was time-and concentration-dependent; and (3) the hydroxyl groups of the benzocycloheptenone ring were probably important for the anti-calicivirus activity of theaflavins. Theaflavins could be used for the calicivirus research, and as potential disinfectants and antiviral reagents to prevent and control calicivirus infections in animals and humans.

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“…Catechin also shows activity against the FCV, which is the surrogate of norovirus. Among catechins tested, EGCG showed the most effective antiviral activity with a half-effective concentration (EC 50 ) of 12 mg/ml with relatively low cytotoxicity with a half-cytotoxic concentration (CC 50 ) of 320 mg/ml (Oh et al 2013). Catechin ointments prepared from GTE have been shown to inhibit the human papillomavirus (HPV) at concentrations from 160 to 360 µM (Tyring, 2012).…”

Section: Feline Calicivirus (Fvs) a Surrogate Of Norovirus And Other mentioning

confidence: 99%

Antiviral effects of green tea (<i>Camellia sinensis</i>) against pathogenic viruses in human and animals (a mini-review)

Mahmood¹,

Martínez²,

Aslam³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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Background: Tea is the second most addictive worldwide after formulations containing caffeine in carbonated beverage. Green tea is made from leaves of the Camellia sinensis plant. In the repertoire of traditional Chinese medicine, green tea beverages have played a fundamental role associated with their culture. It has been suggested that green tea has a number of positive health benefits that are reviewed and discussed in this minireview. Materials and Methods:We performed a search using the key words "green tea" AND "antiviral" covering the last 10 years. The consulted data based were PubMed, ISI Web of Knowledge, Scopus, Reuters and Thomson. Results:The results of the searching greatly support that green tea presents both antibacterial and antiviral effects. The beneficial effects of green tea are mainly attributed to the presence of a type of polyphenols known as catechins and formed by several isomers including (-) -epigallocatechin gallate (EGCG), (-) -epigallocatechin, (-) -epicatechin gallate, (-) -epicatechin, and (+) -catechin. The catechins in green tea have a wide range of antiviral activity against a variety of viruses that act by interfering with its replication cycle. Conclusion: A detailed information on the antiviral activity of green tea in a number of different viruses show a promising future as a popular drink and also as a potential therapeutic agent.

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Antiviral activity of green tea catechins against feline calicivirus as a surrogate for norovirus

Cited by 34 publications

References 20 publications

Phaeophyta Extracts Exhibit Antiviral Activity against Feline Calicivirus

Phaeophyta Extracts Exhibit Antiviral Activity against Feline Calicivirus

Antiviral effect of theaflavins against caliciviruses

Antiviral effects of green tea (<i>Camellia sinensis</i>) against pathogenic viruses in human and animals (a mini-review)

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