Antiviral activity of
            <i>Humulus lupulus</i>
            (HOP) aqueous extract against MERS-CoV and SARS-CoV-2: in-vitro and in-silico study

Bouback, Thamer A.; Aljohani, Amal Mohammed; Albeshri, Abdulaziz; Al-Talhi, Hasan A.; Moatasim, Yassmin; Gaballah, Mohamed S.; Badierah, Raied; Albiheyri, Raed; Al-Sarraj, Faisal; Ali, Mohamed A.

doi:10.1080/13102818.2022.2158133

Cited by 5 publications

(4 citation statements)

References 44 publications

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“…Recently, Bouback et al showed that a boiled water extract from the dried whole plant of H. lupulus possessed anticoronaviral properties against both MERS-CoV and SARS-CoV-2, blocking the viral ability to infect and replicate inside the host cells: these effects are mainly ascribed to its polyphenolic compounds [102]. The authors also predicted in silico that the compounds 5 -prenylxanthohumol, dehydrocycloxanthohumol hydrate, isoxanthohumol, xanthogalenol, 6-prenylnaringenin, catechin gallate, epicatechin gallate, 8-prenylnaringenin and xanthohumol may likely act as SARS-CoV-2 and MERS-CoV inhibitors by binding to the receptor-binding domain (RBD) of the spike proteins [102]. According to these predictions, previous studies have focused on xanthohumol as a broadspectrum antiviral agent [103][104][105][106].…”

Section: Discussionmentioning

confidence: 99%

ECHOPvir: A Mixture of Echinacea and Hop Extracts Endowed with Cytoprotective, Immunomodulatory and Antiviral Properties

Percaccio,

De Angelis,

Acquaviva

et al. 2023

Nutrients

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Respiratory viral infections continue to pose significant challenges, particularly for more susceptible and immunocompromised individuals. Nutraceutical strategies have been proposed as promising strategies to mitigate their impact and improve public health. In the present study, we developed a mixture of two hydroalcoholic extracts from the aerial parts of Echinacea purpurea (L.) Moench (ECP) and the cones of Humulus lupulus L. (HOP) that can be harnessed in the prevention and treatment of viral respiratory diseases. The ECP/HOP mixture (named ECHOPvir) was characterized for the antioxidant and cytoprotective properties in airway cells. Moreover, the immunomodulating properties of the mixture in murine macrophages against antioxidant and inflammatory stimuli and its antiviral efficacy against the PR8/H1N1 influenza virus were assayed. The modulation of the Nrf2 was also investigated as a mechanistic hypothesis. The ECP/HOP mixture showed a promising multitarget bioactivity profile, with combined cytoprotective, antioxidant, immunomodulating and antiviral activities, likely due to the peculiar phytocomplexes of both ECP and HOP, and often potentiated the effect of the single extracts. The Nrf2 activation seemed to trigger these cytoprotective properties and suggest a possible usefulness in counteracting the damage caused by different stressors, including viral infection. Further studies may strengthen the interest in this product and underpin its future nutraceutical applications.

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Section: Discussionmentioning

confidence: 99%

ECHOPvir: A Mixture of Echinacea and Hop Extracts Endowed with Cytoprotective, Immunomodulatory and Antiviral Properties

Percaccio,

De Angelis,

Acquaviva

et al. 2023

Nutrients

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“…These substances address conditions like nervous tension, headaches, sleep disorders [ 14 , 15 , 16 ], and also reportedly help with lack of appetite, anemia, bacterial infections, dermatitis, and diarrhea [ 17 ]. In recent years, Hop extracts have shown efficacy in reducing oxidative stress induced by iron overload [ 18 ] and exhibit anti-coronavirus properties [ 19 ], demonstrating diverse applications in the biomedical field. Reports from the past century highlight the diverse traditional uses of H. lupulus , extending beyond medicinal applications.…”

Section: Introductionmentioning

confidence: 99%

Updating the Knowledge on the Secretory Machinery of Hops (Humulus lupulus L., Cannabaceae)

Ramos,

Iwamoto,

Piva

et al. 2024

Plants

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Cannabaceae species garner attention in plant research due to their diverse secretory structures and pharmacological potential associated with the production of secondary metabolites. This study aims to update our understanding of the secretory system in Hops (Humulus lupulus L.), an economically important species especially known for its usage in beer production. For that, stems, leaves, roots, and inflorescences were collected and processed for external morphology, anatomical, histochemical, ultrastructural and cytochemical analyses of the secretory sites. Our findings reveal three types of secretory structures comprising the secretory machinery of Hops: laticifer, phenolic idioblasts and glandular trichomes. The laticifer system is articulated, anastomosing and unbranched, traversing all plant organs, except the roots. Phenolic idioblasts are widely dispersed throughout the leaves, roots and floral parts of the species. Glandular trichomes appear as two distinct morphological types: capitate (spherical head) and peltate (radial head) and are found mainly in foliar and floral parts. The often-mixed chemical composition in the secretory sites serves to shield the plant from excessive UVB radiation, elevated temperatures, and damage inflicted by herbivorous animals or pathogenic microorganisms. Besides the exudate from peltate glandular trichomes (lupulin glands), latex and idioblast content are also likely contributors to the pharmacological properties of different Hop varieties, given their extensive presence in the plant body.

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“…Laurus nobilis essential oil, with beta-ocimene, 1,8-cineole, alpha-pinene, and beta-pinene as its main constituents, has also been shown to exert antiviral activity against SARS-CoV, with an IC 50 value of 120 mg/mL [13] . More recent works reviewed the antiviral activity of plant secondary metabolites as a possible SARS-CoV-2 Treatment [14] , assessed the Antiviral activity of Humulus lupulus against MERS-CoV using in-vitro and in-silico tools [15] and investigated the antiviral effects of Saussurea lappa root extract against SARS-CoV-2 in vitro and in animal models [16] .…”

Section: Introductionmentioning

confidence: 99%

Terpenes and cannabidiol against human corona and influenza viruses–Anti-inflammatory and antiviral in vitro evaluation

Chatow,

Nudel,

Eyal

et al. 2024

Biotechnology Reports

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Antiviral activity of Humulus lupulus (HOP) aqueous extract against MERS-CoV and SARS-CoV-2: in-vitro and in-silico study

Cited by 5 publications

References 44 publications

ECHOPvir: A Mixture of Echinacea and Hop Extracts Endowed with Cytoprotective, Immunomodulatory and Antiviral Properties

ECHOPvir: A Mixture of Echinacea and Hop Extracts Endowed with Cytoprotective, Immunomodulatory and Antiviral Properties

Updating the Knowledge on the Secretory Machinery of Hops (Humulus lupulus L., Cannabaceae)

Terpenes and cannabidiol against human corona and influenza viruses–Anti-inflammatory and antiviral in vitro evaluation

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