Antiviral Activity of Naturally Occurring Anthraquinones and Anthraquinone Derivatives

Wood, Steve; Huffman, John H.; Weber, Norbert D.; Andersen, Douglas O.; North, James A.; Murray, Byron K.; Sidwell, Robert W.; Hughes, Bronwyn G.

doi:10.1055/s-2006-961304

Cited by 24 publications

(10 citation statements)

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“…Flavonoid-and catechin-containing fractions of St John's wort have exhibited activity against influenza virus (Mishenkova et al 1975). Hypericin and pseudohypericin have been reported to inhibit several encapsulated viruses in-vitro, including herpes simplex virus types 1 and 2 (Wood et al 1990 ;Weber et al 1994), and human immunodeficiency virus (HIV)-1 (Meruelo et al 1988 ;Lavie et al 1989 ;Hudson et al 1991 ;Lopez-Bazzocchi et al 1991). Hypericin has also been reported to inactivate murine cytomegalovirus (MCMV) and Sindbis virus .…”

Section: Antiviral Activitymentioning

confidence: 99%

St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties

Barnes

Anderson

Phillipson

2001

Journal of Pharmacy and Pharmacology

694

462

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The chemical composition of St. John's wort has been well-studied. Documented pharmacological activities, including antidepressant, antiviral, and antibacterial effects, provide supporting evidence for several of the traditional uses stated for St John's wort. Many pharmacological activities appear to be attributable to hypericin and to the flavonoid constituents ; hypericin is also reported to be responsible for the photosensitive reactions that have been documented for St. John's wort. With regard to the antidepressant effects of St John's wort, hyperforin, rather than hypericin as originally thought, has emerged as one of the major constituents responsible for antidepressant activity. Further research is required to determine which other constituents contribute to the antidepressant effect.Evidence from randomised controlled trials has confirmed the efficacy of St John's wort extracts over placebo in the treatment of mild-to-moderately severe depression. Other randomised controlled studies have provided some evidence that St John's wort extracts are as effective as some standard antidepressants in mild-to-moderate depression. There is still a need for further trials to assess the efficacy of St John's wort extracts, compared with that of standard antidepressants, particularly newer antidepressant agents, such as the selective serotonin reuptake inhibitors (recent comparative studies with fluoxetine and sertraline have been conducted). Also, there is a need for further studies in well-defined groups of patients, in different types of depression, and conducted over longer periods in order to determine longterm safety. St John's wort does appear to have a more favourable short-term safety profile than do standard antidepressants, a factor that is likely to be important in patients continuing to take medication.Concerns have been raised over interactions between St John's wort and certain prescribed medicines (including warfarin, ciclosporin, theophylline, digoxin, HIV protease inhibitors, anticonvulsants, selective serotonin reuptake inhibitors, triptans, oral contraceptives) ; advice is that patients taking these medicines should stop taking St John's wort, generally after seeking professional advice as dose adjustment of conventional treatment may be necessary.

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Section: Antiviral Activitymentioning

confidence: 99%

St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties

Barnes

Anderson

Phillipson

2001

Journal of Pharmacy and Pharmacology

694

462

View full text Add to dashboard Cite

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“…Antitumoral effects are also cited (Duke, 1985). Hypericum perforatum has been reported to possess marked antimicrobial (Pei-Gen, 1994), antiviral (Serkedjieva et al, 1990) and anti-HIV/anti-AIDS (Wood et al, 1990) activities. Hypericin and pseudohypericin also display an antiretroviral activity (Lavie et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Wound-healing activity of St. John's Wort (Hypericum perforatum L.) on chicken embryonic fibroblasts

Oztürk

Korkmaz

Öztürk

2007

Journal of Ethnopharmacology

130

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“…They are typically deposited on the outer cell wall of the fungal hyphae and are water insoluble. Various biological roles of lichen secondary metabolites such as antibacterial, anticancer, anti-virus, anti-fungal, anti-protozoal, and insecticides have already been documented (Wood et al, 1990;Yamamoto et al, 1995;Neamati et al, 1997;Schmeda-Hirschmann et al, 2008;Shrestha and St. Clair, 2013). Primary metabolites are generally intracellular and include proteins, amino acids, polyols, carotenoids, polysaccharides, and vitamins (Nash, 2008).…”

Section: Lichen Metabolitesmentioning

confidence: 99%

The Immunostimulating Role of Lichen Polysaccharides: A Review

2014

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The immune system has capacity to suppress the development or progression of various malignancies including cancer. Research on the immunomodulating properties of polysaccharides obtained from plants, microorganisms, marine organisms, and fungi is growing rapidly. Among the various potential sources, lichens, symbiotic systems involving a fungus and an alga and/or a cyanobacterium, show promise as a potential source of immunomodulating compounds. It is well known that lichens produce an abundance of structurally diverse polysaccharides. However, only a limited number of studies have explored the immunostimulating properties of lichen polysaccharides. Published studies have shown that some lichen polysaccharides enhance production of nitrous oxide (NO) by macrophages and also alter the production levels of various proinflammatory and antiinflammatory cytokines (IL-10, IL-12, IL-1β, TNF-α, and IFN-α/β) by macrophages and dendritic cells. Although there are only a limited number of studies examining the role of lichen polysaccharides, all results suggest that lichen polysaccharides can induce immunomodulatory responses in macrophages and dendritic cells. Thus, a detailed evaluation of immunomodulatory capacity of lichen polysaccharides could provide a unique opportunity for the discovery of novel therapeutic agents.

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Antiviral Activity of Naturally Occurring Anthraquinones and Anthraquinone Derivatives

Cited by 24 publications

References 0 publications

St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties

St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties

Wound-healing activity of St. John's Wort (Hypericum perforatum L.) on chicken embryonic fibroblasts

The Immunostimulating Role of Lichen Polysaccharides: A Review

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