Antiviral Activity of New Derivatives of Cage Compounds

Klimochkin, Yu. N.; Osyanin, V. A.; Krasnikov, P. E.; Леонова, М. В.; Golovin, E. T.; Balakhnin, S. M.; Belanov, E. F.

doi:10.1016/j.antiviral.2009.02.144

Antiviral Research

2009

DOI: 10.1016/j.antiviral.2009.02.144

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Antiviral Activity of New Derivatives of Cage Compounds

Yu. N. Klimochkin

V. A. Osyanin

P. E. Krasnikov

et al.

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“…Viral proteins acting as ion channels and the cell membrane scaffold, can be the targets of the so constructed drugs [21][22][23][24][25][26][27].…”

mentioning

confidence: 99%

Synthesis of adamantyl-containing cidofovir analogs as potential antiviral prodrugs with high bioavailability parameters

et al. 2015

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We report on preparation of potential nucleoside phosphonate prodrugs: 1-{3-hydroxy-2-[О-(adamantylalkyl)phosphorylmethoxy]propyl}cytosines containing two structural fragments providing antiviral activity, nucleoside phosphonate and adamantyl sites.Nucleoside phosphonates (adefovir, cidofovir, tenofovir, and their analogs) are promising antiviral drugs of the new generation. These compounds has shown high efficacy against genomic DNA viruses [1-4] confirmed on a set of experimental models in vitro and in vivo [5][6][7][8][9].

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“…Viral proteins acting as ion channels and the cell membrane scaffold, can be the targets of the so constructed drugs [21][22][23][24][25][26][27].…”

mentioning

confidence: 99%

Synthesis of adamantyl-containing cidofovir analogs as potential antiviral prodrugs with high bioavailability parameters

et al. 2015

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Antiviral Activity of New Derivatives of Cage Compounds

Cited by 1 publication

References 0 publications

Synthesis of adamantyl-containing cidofovir analogs as potential antiviral prodrugs with high bioavailability parameters

Synthesis of adamantyl-containing cidofovir analogs as potential antiviral prodrugs with high bioavailability parameters

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