Antiviral Activity of Resveratrol against Human and Animal Viruses

Abba, Yusuf; Hassim, Hasliza Abu; Hamzah, Hazilawati; Noordin, M. M.

doi:10.1155/2015/184241

Cited by 139 publications

(118 citation statements)

References 42 publications

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“…Resveratrol inhibits the replication of several viruses, including herpes simplex viruses (HSVs) 1 and 2, varicella-zoster virus, papillomaviruses, and influenza virus (9)(10)(11)(12). Topical application of resveratrol has been found to inhibit HSV vaginal transmission in mice, suggesting that it might be useful as a topical microbicide (13).…”

mentioning

confidence: 99%

Potent Inhibition of HIV-1 Replication in Resting CD4 T Cells by Resveratrol and Pterostilbene

Chan

Trinité

Levy

2017

Antimicrob Agents Chemother

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HIV-1 infection of resting CD4 T cells plays a crucial and numerically dominant role during virus transmission at mucosal sites and during subsequent acute replication and T cell depletion. Resveratrol and pterostilbene are plant stilbenoids associated with several health-promoting benefits. Resveratrol has been shown to inhibit the replication of several viruses, including herpes simplex viruses 1 and 2, papillomaviruses, severe acute respiratory syndrome virus, and influenza virus. Alone, resveratrol does not inhibit HIV-1 infection of activated T cells, but it does synergize with nucleoside reverse transcriptase inhibitors in these cells to inhibit reverse transcription. Here, we demonstrate that resveratrol and pterostilbene completely block HIV-1 infection at a low micromolar dose in resting CD4 T cells, primarily at the reverse transcription step. The anti-HIV effect was fully reversed by exogenous deoxynucleosides and Vpx, an HIV-1 and simian immunodeficiency virus protein that increases deoxynucleoside triphosphate (dNTP) levels. These findings are consistent with the reported ability of resveratrol to inhibit ribonucleotide reductase and to lower dNTP levels in cells. This study supports the potential use of resveratrol, pterostilbene, or related compounds as adjuvants in anti-HIV preexposure prophylaxis (PrEP) formulations.KEYWORDS resting CD4 T cells, human immunodeficiency virus, pterostilbene, resveratrol, reverse transcription, stilbenoid, PrEP T he stilbenoids resveratrol (RES) and pterostilbene (PTE) function as plant phytoalexins, i.e., defensive compounds generated in response to parasitic attack. Resveratrol is found in grape skins, small berries, peanuts, and some nuts and has been extensively studied as an active ingredient of red wine, contributing to the health benefits associated with the French paradox and other potential life-extending properties, including anti-inflammatory, anticancer, and antidiabetes activities (1). Pterostilbene is a natural dimethylated analog of resveratrol also found in grape skins, berries, peanuts, and almonds (2). Pterostilbene has anti-inflammatory activity (3, 4), is more lipophilic than resveratrol, and has greater stability in vitro and in vivo (5-8).Resveratrol inhibits the replication of several viruses, including herpes simplex viruses (HSVs) 1 and 2, varicella-zoster virus, papillomaviruses, and influenza virus (9-12). Topical application of resveratrol has been found to inhibit HSV vaginal transmission in mice, suggesting that it might be useful as a topical microbicide (13). Alone, resveratrol does not inhibit wild-type (WT) human immunodeficiency virus type 1 (HIV-1) replication in activated T cells or in transformed T cell lines (14, 15), but it does potentiate inhibition of reverse transcription by nucleoside analog reverse transcriptase (RT) inhibitors (NRTIs), including tenofovir (TFV), didanosine, zidovudine (AZT), and emtricitabine (FTC) (14,16). Resveratrol alone does, however, inhibit reverse transcription in NRTI-resistant RT muta...

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mentioning

confidence: 99%

Potent Inhibition of HIV-1 Replication in Resting CD4 T Cells by Resveratrol and Pterostilbene

Chan

Trinité

Levy

2017

Antimicrob Agents Chemother

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“…It has been reported that resveratrol and its derivatives possess antiviral activity with diverse mechanisms, including inhibition of viral protein synthesis or transcription and modulating viral related gene expressions or signaling pathways in host cells [Abba et al, ]. A number of studies have shown that resveratrol and its derivatives inhibit the replication of different viruses such as herpes simplex [Docherty et al, ], varicella‐zoster [Docherty et al, ], and influenza A [Palamara et al, ; Li et al, ].…”

Section: Discussionmentioning

confidence: 99%

Identification of resveratrol analogs as potent anti‐dengue agents using a cell‐based assay

Han

Penthala

Oliveira

et al. 2016

Journal of Medical Virology

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Dengue virus (DENV) causes a variety of difficult-to-treat diseases that threaten almost half of the world's population. Currently, no effective vaccine or antiviral therapy is available. We have examined a series of synthetic resveratrol analogs to identify potential anti-DENV agents. Here, we demonstrate that two resveratrol analogs, PNR-4-44 and PNR-5-02, possess potent anti-DENV activity with EC values in the low nanomolar range. These two resveratrol analogs were shown to mainly target viral RNA translation and viral replication, but PNR-5-02 is also likely to target cellular factors inside host cells. Although the precise molecular mechanism(s) mediating anti-DENV activities have not been elucidated, further structure-guided design might lead to the development of newer improved resveratrol derivatives that might have therapeutic value. J. Med. Virol. 89:397-407, 2017. © 2016 Wiley Periodicals, Inc.

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“…Different polyphenols are active against several types of influenza virus (Table 2). Between them, RSV is well known for its antiviral effects against H1N1 type by blocking the nuclear-cytoplasmic translocation of the viral ribonucleoproteins and consequently by inhibition of the protein kinase C associated pathways (Abba, Hassim, Hamzah, & Noordin, 2015).…”

Section: Influenza Virusmentioning

confidence: 99%

Antiviral activity of plants and their isolated bioactive compounds: An update

Denaro

Smeriglio

Barreca

et al. 2019

Phytotherapy Research

131

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Viral infections represent one of the main causes of disease worldwide, especially today due to the increase of migration, global travel, and urbanization. The several side effects of the conventional drugs and the growing phenomenon of resistance have led researchers to turn to the plant kingdom as a source of potential new antiviral drugs. The aim of this work is to summarize the updated evidence for antiviral activity of different plants and their isolated bioactive compounds, evaluating also the potential interactions, which can occur in cotreatment with conventional antiviral drugs. The plant complexes have proved to be usually more active than their most abundant isolated compounds by hypothesizing synergistic mechanisms. In addition to cellular and molecular investigations, molecular docking studies have proved essential in highlighting the interaction mechanisms of bioactive compounds with target molecules. However, the use of nonstandardized extracts, or too high concentrations in vitro, which do not reproduce their bioavailability in vivo, are often limiting factors. Moreover, the lack of studies concerning the safety profile of plant extracts and their isolated compounds, alone or in combination with conventional antiviral drugs, is the most worrying aspect. In light of this, further studies are needed to validate their possible therapeutic use.

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Antiviral Activity of Resveratrol against Human and Animal Viruses

Cited by 139 publications

References 42 publications

Potent Inhibition of HIV-1 Replication in Resting CD4 T Cells by Resveratrol and Pterostilbene

Potent Inhibition of HIV-1 Replication in Resting CD4 T Cells by Resveratrol and Pterostilbene

Identification of resveratrol analogs as potent anti‐dengue agents using a cell‐based assay

Antiviral activity of plants and their isolated bioactive compounds: An update

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