Antiviral and anti-proliferative in vitro activities of piperamides from black pepper

Mair, CE; Liu, R; Atanasov, AG; Schmidtke, Michaela; Dirsch, VM; Rollinger, JM

doi:10.1055/s-0036-1596830

Cited by 28 publications

(23 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Likewise, other ingredients of herbal tea i.e. Cinnamomum verum [ 21 ], Piper nigrum (composes the piperamides) [ 22 ], Zingiber officinale [ 23 ], and Vitis vinifera [ 24 , 25 ] are also reported for their potential antiviral and anti-inflammatory property. Since COVID-19 is associated with viral infection and inflammation of lung tissues, the anti-viral and anti-inflammatory properties of the above medicinal plants may add a beneficial effect against COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology of AYUSH recommended immune-boosting medicinal plants against COVID-19

Khanal¹,

Duyu²,

Patil³

et al. 2022

Journal of Ayurveda and Integrative Medicine

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Network pharmacology of AYUSH recommended immune-boosting medicinal plants against COVID-19

Khanal¹,

Duyu²,

Patil³

et al. 2022

Journal of Ayurveda and Integrative Medicine

View full text Add to dashboard Cite

“…Health beneficial and disease preventing properties, like anti-inflammatory, antiviral, antipyretic, immune and bioavailability enhancing qualities Mair et al (2016) Black Pepper (Piper nigrum) Figure 9. A-L: Structural and chemical properties of antiviral and Phyto Drugs: Representative 3 D structure of FDA approved antiviral drugs A) Adefovir B) Amantadine C) Oseltamivir D) Ribavirin E) Zanamivir.…”

Section: Piperinementioning

confidence: 99%

“…Piperine have many health benefits and disease preventing properties like e.g. anti-inflammatory, antiviral, antipyretic, immune and bioavailability enhancing qualities (Mair et al., 2016 ). Based on the above properties we recommend in vitro testing and clinical trials of these highly beneficial compounds for their impact on recovery of patients suffering from Covid-19, potential reduction in severity and duration of the infections.…”

Section: Introductionmentioning

confidence: 99%

Computational investigation for identification of potential phytochemicals and antiviral drugs as potential inhibitors for RNA-dependent RNA polymerase of COVID-19

Singh

Malik

Raina

2020

Journal of Biomolecular Structure and Dynamics

View full text Add to dashboard Cite

“…screened compounds from Indian spices as potent inhibitors of SARS-CoV-2 Mpro (Umesh et al., 2020 ). Every spice has a particular aroma, colour and flavour due to the presence of specific molecules in them, and also, have antiviral properties (Aboubakr et al., 2016 ; Astani et al., 2010 ; Brochot et al., 2017 ; Chang et al., 2013 ; Choi, 2016 ; Mair et al., 2016 ; Zhang et al., 2014 ). These properties of the spice molecules compel us to conduct the present study, where we investigated the inhibition property of molecules present in various spices against the SARS-CoV-2 RBD Spro and SARS-Cov-2 Mpro using molecular docking and MD simulation studies.…”

Section: Introductionmentioning

confidence: 99%

In silicoinvestigation of spice molecules as potent inhibitor of SARS-CoV-2

Rout

Swain

Tripathy

2020

Journal of Biomolecular Structure and Dynamics

View full text Add to dashboard Cite

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel infectious disease that is in rapid growth. Several trials are going on worldwide to find a solution for this pandemic. The viral replication can be blocked by inhibiting the receptor-binding domain (RBD) of SARS-CoV-2 spike protein (SARS-CoV-2 RBD Spro) and the SARS-CoV-2 main protease (SARS-CoV-2 Mpro). The binding of potential small molecules to these proteins can inhibit the replication and transcription of the virus. The spice molecules that are used in our food have antiviral, antifungal and antimicrobial properties. As spice molecules are consumed in the diet, hence its antiviral properties against SARS-CoV-2 will benefit in a significant manner. Therefore, in this work, the molecular docking of 30 selected spice molecules (screened through ADME property) was performed to identify the potential inhibitors for the RBD Spro and Mpro of SARS-CoV-2. We have found that though all the molecules bind actively with the SARS-CoV-2 RBD Spro and Mpro, but Piperine has the highest binding affinity among the 30 screened molecules. Besides, the comparative study between Piperine and currently used drugs show that Piperine is more effective. The interaction of Piperine with RBD Spro and Mpro is further validated by the molecular dynamics (MD) simulation studies. The free energy landscape and binding free energy results also, support for the stable complex formation of Piperine with RBD Spro and Mpro. We anticipate immediate wet-lab experiments and clinical trials in support of this computational study that might help to inhibit the SARS-CoV-2 virus.

show abstract

Antiviral and anti-proliferative in vitro activities of piperamides from black pepper

Cited by 28 publications

References 0 publications

Network pharmacology of AYUSH recommended immune-boosting medicinal plants against COVID-19

Network pharmacology of AYUSH recommended immune-boosting medicinal plants against COVID-19

Computational investigation for identification of potential phytochemicals and antiviral drugs as potential inhibitors for RNA-dependent RNA polymerase of COVID-19

In silicoinvestigation of spice molecules as potent inhibitor of SARS-CoV-2

Contact Info

Product

Resources

About