Antiviral carboxylic acids and naphthoquinones from the stems of Rhinacanthus nasutus

Thongchuai, Benchaluk; Tragoolpua, Yingmanee; Sangthong, Padchanee; Trisuwan, Kongkiat

doi:10.1016/j.tetlet.2015.07.082

Cited by 9 publications

(4 citation statements)

References 6 publications

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“…Traditionally, R. nasutus is used in the treatment of ringworm, bacterial/fungal infections, and diabetes (Boonyaketgoson, Rukachaisirikul, Phongpaichit, & Trisuwan, ; Shah, Jakkawanpitak, Sermwittayawong, & Panichayupakaranant, ). The constituents of therapeutic value found in R. nasutus are naphthoquinones, which have been reported to display anti‐inflammatory, cytotoxic, acetylcholinesterase inhibitory, antidiabetic, and antiviral properties (Boonyaketgoson et al, ; Tewtrakul, Tansakul, & Panichayupakaranant, ; Thongchuai, Tragoolpua, Sangthong, & Trisuwan, ; Wu, Tien, Yeh, & Lee, ). The standardized rhinacanthins‐rich extract (RRE) from R. nasutus, consisting of rhinacanthins C, D and N (62.2% of RC, 7.9% of RD, 3.6% of RN w/w, Figure ) has been established (Panichayupakaranant, Charoonratana, & Sirikatitham, ).…”

Section: Introductionmentioning

confidence: 99%

Rhinacanthins‐rich extract and rhinacanthin C ameliorate oxidative stress and inflammation in streptozotocin‐nicotinamide‐induced diabetic nephropathy

et al. 2019

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In this present study, rhinacanthins‐rich extract (RRE) and rhinacanthin C (RC) the main bioactive constituent of Rhinacanthus nasutus was investigated for their protective effect against diabetic nephropathy (DN). Diabetes was induced by administering nicotinamide (100 mg/kg, i.p.)/streptozotocin (60 mg/kg, i.p.) and diabetic rats were orally administered with RRE and RC for 4 weeks. RRE and RC significantly reduced the kidney index, renal oxidative stress markers, and pro‐inflammatory cytokines. Furthermore, RRE and RC increased renal levels of glutathione, superoxide dismutase, catalase, and attenuated diabetic induced renal damages. In conclusion, RRE and RC confer protective effect against DN through the inhibition of oxidative stress and inflammation and could be a potential medicinal or nutritional supplement for the prevention of DN. Practical applications Rhinacanthus nasutus is a medicinal plant that is extensively used in Thai traditional medicine as an antibacterial, antifungal, antidiabetic, and anti‐inflammatory agent. The plant is rich in naphthoquinones, which confer it with several excellent bioactivities. The rich extract of the leaves was prepared with three major bioactive components and the extract was evaluated for its renoprotective effect in diabetic rats. The results from this study provides valuable pharmacological information that supports the use of the plant, especially the rich extract in the prevention and treatment of diabetes and diabetic complications.

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Section: Introductionmentioning

confidence: 99%

Rhinacanthins‐rich extract and rhinacanthin C ameliorate oxidative stress and inflammation in streptozotocin‐nicotinamide‐induced diabetic nephropathy

et al. 2019

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“…[53]. Carboxylic acids, rhinacanthinic acids A-C, naphthoquinones, and lactones were isolated from R. nasutus against the herpes simplex virus type-2 (HSV-2) [54]. Ethanolic extract of T. triandra, a main ingredient in Ya-Ha-Rak, exhibited anti-dengue virus serotype 2 [55].…”

Section: Discussionmentioning

confidence: 99%

Extended biological activities of a Thai traditional medicine formula recorded in an inscription at Wat Pho used for the treatment of COVID-19

Perstwong,

Binalee,

Kobtrakul

et al. 2024

Preprint

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Background In Thai traditional history, Ya-Kao (YK) is a traditional medicine used to relieve fever. Several Thai folk healers have recommended the use of YK for COVID-19 during pre-treatment, treatment, and post-treatment. The Department of Thai Traditional and Alternative Medicine (DTAM) has accepted YK for COVID-19-infected patients and has been observing its effectiveness in a clinical study. Fourteen plants are the main raw materials of the YK formula, which currently lacks scientific information to support its properties. The study aims to investigate the chemical profile of YK and its biological properties by measuring the antibacterial and anti-inflammatory effects, in vitro study. Methods YK investigated the chemical profile of the formula based on the raw plant materials by using High-Performance Thin Layer Chromatography (HPTLC). In vitro, the antibacterial activity was conducted by agar disc diffusion and TLC-bioautography. The anti-inflammatory activity was conducted by nitric oxide (NO) production assay in RAW 264.7 macrophages which the inflammatory effect was induced by lipopolysaccharide (LPS). Results This study successfully explores the HPTLC method for analyzing the quality of YK raw materials. Whereas the pharmacological property of YK is examined. YK-lime juice extract exhibits the most effective antibacterial activity against both gram-positive and gram-negative bacteria. In addition, the methanolic extract of YK inhibited Streptococcus pyogenes and Klebsiella pnuemoniae by the TLC-bioautography method. Furthermore, YK extracts of methanol, water, and lime juice demonstrate significant anti-inflammatory properties, evidenced by a notable reduction in NO production in a macrophage model induced by LPS. Conclusions Overall, these pharmacological data could support the property of YK, a Thai Traditional medicine. It may be consumed to reduce inflammation and antibacterial co-infection not only for COVID-19 but also for other respiratory infections.

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“…1,2 Trong một số thử nghiệm hoạt tính sinh học trên các dịch chiết của cây cho thấy cây Kiến cò có tác dụng tiềm năng để điều trị một số bệnh như điều trị ung thư, rối loạn chức năng của gan, bệnh ngoài da, loét dạ dày tá tràng, giun sán, bệnh ghẻ, viêm và béo phì. 3 Các nghiên cứu về thành phần hóa học của cây Kiến cò cho thấy trong cây có các hợp chất naphthoquinone, anthraquinone, lignan, flavonoid, phenol, triterpenoid và sterol…, [4][5][6][7][8][9][10][11][12][13][14][15] các nghiên cứu cũng cho thấy cây Kiến cò có hoạt tính kháng ung thư, kháng khuẩn, kháng nấm, kháng tiểu cầu… 8,13,15,16 Ở Việt Nam, cho đến nay chỉ mới tìm thấy một nghiên cứu về thành phần hóa học của cây Kiến cò 4 và hầu như chưa có nghiên cứu nào về hoạt tính sinh học. Do các nghiên cứu về cây Kiến cò còn rất ít và hạn chế, vì vậy việc tiến hành nghiên cứu thành phần hóa học và hoạt tính sinh học trên loài cây này sẽ giúp định hướng cho các nghiên cứu ứng dụng sâu hơn và có thể sử dụng loài dược liệu này hiệu quả hơn.…”

Section: Mở đầUunclassified

Chemical constituents of ethyl acetate from the leaves of Rhinacanthus nasutus

Huynh Thanh,

Do Van Nhat,

Tran Le

et al. 2023

Sci. Tech. Dev. J. - Nat. Sci.

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Rhinacanthus nasutus, called “Kiến cò” in Vietnam, belonged to the family of Acanthaceae. All parts of R. nasutus are used in traditional medicine to cure eczema, herpes, tuberculosis, hepatitis, diabetes, and hypertension... Phytochemical studies on its chemical constituents have led to the identification of many types of secondary metabolites, including naphthoquinones, anthraquinones, lignans, flavonoids, phenolics, triterpenoids, and sterols, which have been found to have cytotoxic, antibacterial, antifungal, and antiplatelet activities. In Vietnam, studies on the R. nasutus were very few and limited, chemical constituents and biological activity studies on this plant will help guide further applied studies and can use this plant more effectively. Dried R. nasutus leaves, collected at Lam Dong Province - Vietnam, was extracted in methanol, and the obtained extract was successively partitioned into n-hexane, ethyl acetate (EtOAc), butanol (n-BuOH). By column chromatography method together with thin layer normal-phase chromatography on the ethyl acetate extract of its leaves, seven compounds were isolated, including umbelliferone (1), skimmin (2), sinensetin (3), kaempferol (4), quercetin (5), rutin (6) and daucosterol (7). Their chemical structures were elucidated by extensive NMR spectroscopic analysis and comparison with the literature data. Among them, skimmin (2), sinensetin (3), kaempferol (4), and quercetin (5) have been obtained in this plant for the first time.

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Antiviral carboxylic acids and naphthoquinones from the stems of Rhinacanthus nasutus

Cited by 9 publications

References 6 publications

Rhinacanthins‐rich extract and rhinacanthin C ameliorate oxidative stress and inflammation in streptozotocin‐nicotinamide‐induced diabetic nephropathy

Rhinacanthins‐rich extract and rhinacanthin C ameliorate oxidative stress and inflammation in streptozotocin‐nicotinamide‐induced diabetic nephropathy

Extended biological activities of a Thai traditional medicine formula recorded in an inscription at Wat Pho used for the treatment of COVID-19

Chemical constituents of ethyl acetate from the leaves of Rhinacanthus nasutus

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