Antiviral Effects and Underlying Mechanisms of Probiotics as Promising Antivirals

Wang, Yanjin; Moon, Assad; Huang, Jingshan; Sun, Yuan; Qiu, Hua‐Ji

doi:10.3389/fcimb.2022.928050

Cited by 18 publications

(14 citation statements)

References 98 publications

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“…Competition for Cellular Binding Sites: Lactobacilli compete with pathogenic viruses for binding sites, limiting viral attachment and entry. Some strains produce bacteriocins and exopolysaccharides inhibiting viral replication [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Lactobacilli in COVID-19: A Systematic Review Based on Next-Generation Sequencing Studies

Taufer,

Rampelotto

2024

Microorganisms

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The global pandemic was caused by the SARS-CoV-2 virus, known as COVID-19, which primarily affects the respiratory and intestinal systems and impacts the microbial communities of patients. This systematic review involved a comprehensive search across the major literature databases to explore the relationship between lactobacilli and COVID-19. Our emphasis was on investigations employing NGS technologies to explore this connection. Our analysis of nine selected studies revealed that lactobacilli have a reduced abundance in the disease and an association with disease severity. The protective mechanisms of lactobacilli in COVID-19 and other viral infections are likely to be multifaceted, involving complex interactions between the microbiota, the host immune system, and the virus itself. Moreover, upon closely examining the NGS methodologies and associated statistical analyses in each research study, we have noted concerns regarding the approach used to delineate the varying abundance of lactobacilli, which involves potential biases and the exclusion of pertinent data elements. These findings provide new insight into the relationship between COVID-19 and lactobacilli, highlighting the potential for microbiota modulation in COVID-19 treatment.

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Section: Discussionmentioning

confidence: 99%

Lactobacilli in COVID-19: A Systematic Review Based on Next-Generation Sequencing Studies

Taufer,

Rampelotto

2024

Microorganisms

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“…The most common probiotics used are species within the Lactobacillus, Bifidiobacterium, and Bacillus genus. Independent of the type of infection, use of probiotics tends towards increasing survival, decreasing pathogen load, or modulating immune responses towards a productive immune response [68][69][70][71][72][73]. Prebiotics such as inulin, polysaccharide, and oligosaccharide have similar effects on infection [69].…”

Section: Probiotics and Bacterial Products As A Therapeutic Optionmentioning

confidence: 99%

Coccidioidomycosis and Host Microbiome Interactions: What We Know and What We Can Infer from Other Respiratory Infections

Tejeda-Garibay

Hoyer

2023

JoF

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Between 70 and 80% of Valley fever patients receive one or more rounds of antibiotic treatment prior to accurate diagnosis with coccidioidomycosis. Antibiotic treatment and infection (bacterial, viral, fungal, parasitic) often have negative implications on host microbial dysbiosis, immunological responses, and disease outcome. These perturbations have focused on the impact of gut dysbiosis on pulmonary disease instead of the implications of direct lung dysbiosis. However, recent work highlights a need to establish the direct effects of the lung microbiota on infection outcome. Cystic fibrosis, chronic obstructive pulmonary disease, COVID-19, and M. tuberculosis studies suggest that surveying the lung microbiota composition can serve as a predictive factor of disease severity and could inform treatment options. In addition to traditional treatment options, probiotics can reverse perturbation-induced repercussions on disease outcomes. The purpose of this review is to speculate on the effects perturbations of the host microbiome can have on coccidioidomycosis progression. To do this, parallels are drawn to aa compilation of other host microbiome infection studies.

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“…The microbiota is therefore of high importance and can influence the effectiveness of the rotavirus or other enteric virus infections. In addition, studies on probiotics are also promising in the prevention phase, and to some extent, also in the curative phase of AGE [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Probiotics as Antiviral Agents for the Treatment of Rotavirus Gastrointestinal Infections in Children: An Updated Overview of Literature

2022

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Enteric viruses, including the rotavirus, norovirus, and adenoviruses, are the most common cause of acute gastroenteritis. The rotavirus disease is especially prevalent among children, and studies over the past decade have revealed complex interactions between rotaviruses and the gut microbiota. One way to treat and prevent dysbiosis is the use of probiotics as an antiviral agent. This review focuses on the latest scientific evidence on the antiviral properties of probiotics against rotavirus gastroenteric infections in children. A total of 19 studies exhibited a statistically significant antiviral effect of probiotics. The main probiotics that were effective were Saccharomyces cerevisiae var. boulardii, Lacticaseibacillus rhamnosus GG, and various multi-strain probiotics. The underlying mechanism of the probiotics against rotavirus gastroenteric infections in children included immune enhancement and modulation of intestinal microbiota leading to shortening of diarrhoea. However, several clinical studies also found no significant difference in the probiotic group compared to the placebo group even though well-known strains were used, thus showing the importance of correct dosage, duration of treatment, quality of probiotics and the possible influence of other factors, such as the production process of probiotics and the influence of immunisation on the effect of probiotics. Therefore, more robust, well-designed clinical studies addressing all factors are warranted.

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Antiviral Effects and Underlying Mechanisms of Probiotics as Promising Antivirals

Cited by 18 publications

References 98 publications

Lactobacilli in COVID-19: A Systematic Review Based on Next-Generation Sequencing Studies

Lactobacilli in COVID-19: A Systematic Review Based on Next-Generation Sequencing Studies

Coccidioidomycosis and Host Microbiome Interactions: What We Know and What We Can Infer from Other Respiratory Infections

The Efficacy of Probiotics as Antiviral Agents for the Treatment of Rotavirus Gastrointestinal Infections in Children: An Updated Overview of Literature

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