Antiviral Isoquinolines from the Cigar Tobacco Derived Endophytic Fungi Aspergillus fumigatus

Pu, Gui; Cha, Xue-Ju; Ma, Yue-Yu; Xiong, Rui-Feng; Zhang, Guang-Hai; Yao, Heng; Wu, Yu-Ping; Bao, Mei-Fen; Li, Yin-Ke; Hu, Qiu-Fen; Kong, Guang-Hui

doi:10.1007/s10600-023-04139-9

Chem Nat Compd

2023

DOI: 10.1007/s10600-023-04139-9

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Antiviral Isoquinolines from the Cigar Tobacco Derived Endophytic Fungi Aspergillus fumigatus

Gui Pu,

Xue-Ju Cha,

Yue-Yu Ma

et al.

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2024

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Isoquinoline alkaloids from endophytic fungus Aspergillus puniceus and their potential as inhibitors for tobacco powdery mildew

Li,

Yao,

et al. 2024

Natural Product Research

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The isoquinoline alkaloids have attracted widespread attention from chemists and biologists. With the aims of screening for biological compounds produced by fungi, three new (1-3), together with four known (4-7) isoquinolines were isolated from the cigar tobacco-derived endophytic fungus Aspergillus puniceus in this study. Their structures were determined by means of HRESIMS and NMR spectroscopic studies. Interestingly, the antifungal activity test revealed that compound 5 showed high antifungal activity against G. cichoracearum. (DC.) (the main pathogen of tobacco powdery mildew disease) with an inhibition rate of 76.3% ± 5.0. Compared to the negative control, compounds 1-4, 6, and 7 also showed notable anti-G. cichoracearum activities with inhibition rates in the range of 38.5%~56.9%. The isolation of the above isoquinolines may provide materials for the study of more potent antifungal inhibitors and contribute to an improved utilization of cigar tobacco-derived endophytic fungi.

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Isoquinoline alkaloids from endophytic fungus Aspergillus puniceus and their potential as inhibitors for tobacco powdery mildew

Li,

Yao,

et al. 2024

Natural Product Research

View full text Add to dashboard Cite

show abstract

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Antiviral Isoquinolines from the Cigar Tobacco Derived Endophytic Fungi Aspergillus fumigatus

Cited by 1 publication

References 26 publications

Isoquinoline alkaloids from endophytic fungus Aspergillus puniceus and their potential as inhibitors for tobacco powdery mildew

Isoquinoline alkaloids from endophytic fungus Aspergillus puniceus and their potential as inhibitors for tobacco powdery mildew

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