Antiviral medication for preventing cytomegalovirus disease in solid organ transplant recipients

Hodson, EM; Barclay, PG; Craig, Jonathan C.; Jones, C; Kable, K; Strippoli, Giovanni F.M.; Vimalachandra, D; Webster, Angela C

doi:10.1002/14651858.cd003774

Cited by 4 publications

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“…Cytomegalovirus (CMV) is a member of the herpes virus family which can cause a mononucleosis like-illness and has a high serology prevalence of 60-100% in most communities [1,2]. Transmission occurs in a bimodal peak, the first peak in infancy likely related to placental transmission and horizontal spread amongst infants, and the second peak in young adulthood related to kissing and sexual transmission [3]. Following initial infection, CMV becomes latent and reactivation is well described in immunocompromised individuals such as those with advanced HIV infection, solid organ transplant, haematological and other malignancies, and undergoing chemotherapy and other immunosuppressants [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…Transmission occurs in a bimodal peak, the first peak in infancy likely related to placental transmission and horizontal spread amongst infants, and the second peak in young adulthood related to kissing and sexual transmission [3]. Following initial infection, CMV becomes latent and reactivation is well described in immunocompromised individuals such as those with advanced HIV infection, solid organ transplant, haematological and other malignancies, and undergoing chemotherapy and other immunosuppressants [3][4][5][6][7][8]. Reactivation can result in end organ disease including the retina, liver, lungs, central nervous system and gastrointestinal system [9].…”

Section: Introductionmentioning

confidence: 99%

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Factors Associated with Cytomegalovirus (CMV) Procto-Colitis in Immunocompetent Adults: A Systematic Review

Bromley,

Lewis,

Fitzpatrick

et al. 2024

Eur J Ther

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Objective: The pathophysiology of CMV procto-colitis in immunocompetent adults is poorly understood. We aimed to systematically review the literature to explore factors, presenting symptoms and endoscopy findings associated with CMV procto-colitis in immunocompetent adults. Methods: Following PRISMA guidelines, we conducted a narrative systematic review by searching MEDLINE, EMBASE, EMCARE and CINAHL for manuscripts published up to August 2023. One author screened manuscript abstracts; two authors independently conducted a full text review. We included manuscripts which included primary data of immunocompetent adults with CMV procto-colitis except case reports. Quality and risk of bias was assessed independently by two authors using the Joanna Briggs institute critical appraisal tools. Results: 8 manuscripts were included in the final review from the USA (n=2), China (n=2), Korea (n=2), India (n=1) and Brazil (n=1) and consisted of 6 case series, one case-control study and one cross-sectional study published between 1988-2022. We identified demographic and behavioural factors (older age, lower BMI, receptive anal sex), infection factors (urinary tract infections, shigellosis, Hepatitis C, COVID-19, sepsis, antimicrobial use), medical conditions (cardiovascular disease, respiratory disease, renal disease, auto-immune disease, diabetes) and hospitalisation factors (intensive care admission, longer length of hospital stay) associated with CMV procto-colitis in immunocompetent adults. Patients presented with rectal bleeding, diarrhoea, melaena, fever, nausea/vomiting, abdominal pain/bloating and constipation. Large bowel endoscopy findings were ulcers, erosions, and erythema and polyp/mass lesions. Conclusion: We have highlighted factors, presenting symptoms and endoscopy findings associated with CMV procto-colitis in immunocompetent patients which provides insight for clinical guideline development and future research.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Factors Associated with Cytomegalovirus (CMV) Procto-Colitis in Immunocompetent Adults: A Systematic Review

Bromley,

Lewis,

Fitzpatrick

et al. 2024

Eur J Ther

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“…4 Las infecciones respiratorias por citomegalovirus se ven favorecidas debido a que las células mesenquimales estromales del pulmón tienen una tasa elevada de infección, por lo que detectar la infección respiratoria por citomegalovirus de forma oportuna permite establecer una terapia eficaz y prevenir otras complicaciones. 5,6 La neumonía causada por citomegalovirus en pacientes trasplantados de médula ósea se ha identificado como una de las principales causas de mortalidad 7 y tienen mayor susceptibilidad a la infección entre los días 30 a 100 después del trasplante.…”

Section: Introductionunclassified

Carga viral para citomegalovirus, en líquido de lavado bronquioalveolar, en población pediátrica

2017

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91www.actapediatrica.org.mx artículo original Acta Pediatr Mex. 2017 mar;38(2):91-100.Carga viral para citomegalovirus, en líquido de lavado bronquioalveolar, en población pediátrica Resumen INTRODUCCIÓN: las infecciones pulmonares son comunes en los pacientes inmunocomprometidos. La carga viral de citomegalovirus se utiliza de rutina para determinar en qué momento se debe iniciar la terapia preventiva en hospederos inmunocomprometidos, diagnosticar enfermedad activa y supervisar la repuesta a una terapia implementada.OBJETIVO: describir el valor de la carga viral de citomegalovirus en líquido de lavado bronquioalveolar vs. sangre periférica en población pediátrica con signos de infección respiratoria. MATERIALES Y MÉTODOS:estudio descriptivo, observacional de 16 pacientes pediátricos y 19 episodios, a quienes se les realizó, de manera simultánea, la carga viral de citomegalovirus en sangre y lavado bronquioalveolar. RESULTADOS Y CONCLUSIONES:todas las cargas virales de citomegalovirus realizadas en lavado bronquioalveolar fueron positivas y en general se obtuvieron valores más elevados que en sangre, lo que sugiere una mayor sensibilidad de la prueba cuando se realiza en este tipo de muestra, en pacientes con sospecha clínica de infección respiratoria por citomegalovirus, lo cual la convierte en una ayuda diagnóstica importante según lo muestran los resultados obtenidos.PALABRAS CLAVE: infección respiratoria, inmunocomprometidos, citomegalovirus, carga viral, líquido de lavado bronquioalveolar.

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Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients

Hodson

Ladhani

Webster

et al. 2013

Cochrane Database of Systematic Reviews

121

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Antiviral medication for preventing cytomegalovirus disease in solid organ transplant recipients

Cited by 4 publications

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Factors Associated with Cytomegalovirus (CMV) Procto-Colitis in Immunocompetent Adults: A Systematic Review

Factors Associated with Cytomegalovirus (CMV) Procto-Colitis in Immunocompetent Adults: A Systematic Review

Carga viral para citomegalovirus, en líquido de lavado bronquioalveolar, en población pediátrica

Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients

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