Antiviral potential of curcumin

Mathew, Dony Chacko; Hsu, Wei‐Li

doi:10.1016/j.jff.2017.12.017

Cited by 206 publications

(145 citation statements)

References 123 publications

Supporting

Mentioning

141

Contrasting

Unclassified

Order By: Relevance

“…It is worth noting that curcumin is the major active compound of the plant with no distinguishable toxicity . Recent studies have shown that curcumin has antiviral, antibacterial, anti‐inflammatory, and antioxidant activities. Furthermore, the therapeutic effects of curcumin and curcumin derivatives have been proven in numerous diseases such as endometriosis, Crohn's disease, pulmonary diseases, cardiac diseases, and kidney diseases .…”

Section: Introductionmentioning

confidence: 99%

Polymersome‐assisted delivery of curcumin: A suitable approach to decrease cancer stemness markers and regulate miRNAs expression in HT29 colorectal cancer cells

Pakizehkar

Ranji

Sohi

et al. 2019

Polymers for Advanced Techs

View full text Add to dashboard Cite

Curcumin as a safe traditional compound has various benefits such as anticancer activities. However, low solubility in water is a problem. Herein, curcumin encapsulated in polymersome nanoparticles (CPNs) have been developed, the physicochemical properties have been evaluated, and cytotoxicity effects on HT29 cells were evaluated by MTT assay and annexin V/PI staining. The expression of stemness markers including CD44, CD133, and CD24, as well as miRNAs (miR‐126, miR‐34a, miR‐21, miR‐155, miR‐221, and miR‐222) and some potential targets, was evaluated in CPNs‐treated and untreated cells. Physicochemical analysis confirmed the encapsulation of curcumin in polymersomes and showed a spherical shape, an appropriate mean size of 259.5±1.5 nm, the acceptable polydispersity index of ~ 0.465, and the zeta potential of (‐8.74±0.2), as well as long‐term storage of CPNs at 4°C. According to the result, CPNs with the IC50 of 14 μg/ml increased apoptosis and induced S arrest in treated cells. Flow cytometry analysis showed the decrease in cancer stemness markers. RT‐qPCR analysis identified the downregulation of miR‐21, miR‐155, and miR‐221/222, as well as upregulation of miR‐34a, miR‐126, and deregulation of some apoptotic targets such as P53, CASP9, CASP8, CASP3, BAX, and BCl‐2 in CPNs‐treated cells. As a result, CPNs can be a safe and effective complementary agent to diminish cancer stem cells and tumor recurrence in colorectal cancer therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

Polymersome‐assisted delivery of curcumin: A suitable approach to decrease cancer stemness markers and regulate miRNAs expression in HT29 colorectal cancer cells

Pakizehkar

Ranji

Sohi

et al. 2019

Polymers for Advanced Techs

View full text Add to dashboard Cite

show abstract

“…We further carefully investigated the inhibition mechanism of the best antiviral agent, Cur‐CQDs‐180, against EV71, although elucidating the exact molecular interactions of the specific functional groups of CQDs and EV71 virions is difficult. Previous studies have demonstrated that antiviral curcumin could interact directly with many proteins, such as DNA polymerase, cell survival proteins, focal adhesion kinase, proteasome, thioredoxin reductase, protein kinase, lipoxygenase, carrier proteins, and tubulin . Therefore, in addition to blocking the viral attachment, the pleiotropic activities of curcumin against viral infection have been demonstrated to emanate from its multiple functions pertaining to a wide range of molecular targets, such as transcription regulation, the activation of intracellular signaling cascades, and the promotion of antioxidative activity.…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, the most important point is that none of them has been demonstrated to be sufficiently effective at the clinical level. In addition to synthetic compound design, natural phytochemical extracts such as flavones, terpenes, polyphenols, steroids, and curcuminoids have shown high potential as anti‐EV71 agents . These natural compounds exhibit various effects, such as targeting viral capsid proteins and proteases and suppressing oxidative stress to inhibit EV71.…”

Section: Resultsmentioning

confidence: 99%

“…To date, studies on herbal‐derived medicines and isolated compounds (e.g., flavone, terpene, polyphenol, and steroid‐related compounds) that target various stages of the virus cycle have shown some promise of inhibiting EV71 . Curcumin has become an attractively therapeutic candidate to treat viral infectious disease …”

Section: Introductionmentioning

confidence: 99%

“…Some studies have indicated that the bioactivities of curcumin are highly dependent on its tautomeric structures . Curcumin and its derivatives have been demonstrated to exhibit inhibitory activity against many viruses, such as human papillomavirus (HPV), human immunodeficiency virus (HIV), herpes simplex virus (HSV), coxsackievirus (CV), and hepatitis C virus (HCV), through various mechanisms . For example, curcumin is capable of modifying long terminal repeat (LTR)‐directed gene expression, inhibiting the acetylation of Tat protein and promoting the Tat protein degradation of HIV .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

High Amplification of the Antiviral Activity of Curcumin through Transformation into Carbon Quantum Dots

Lin

Chang

Chu

et al. 2019

Small

129

116

View full text Add to dashboard Cite

It is demonstrated that carbon quantum dots derived from curcumin (Cur‐CQDs) through one‐step dry heating are effective antiviral agents against enterovirus 71 (EV71). The surface properties of Cur‐CQDs, as well as their antiviral activity, are highly dependent on the heating temperature during synthesis. The one‐step heating of curcumin at 180 °C preserves many of the moieties of polymeric curcumin on the surfaces of the as‐synthesized Cur‐CQDs, resulting in superior antiviral characteristics. It is proposed that curcumin undergoes a series of structural changes through dehydration, polymerization, and carbonization to form core–shell CQDs whose surfaces remain a pyrolytic curcumin‐like polymer, boosting the antiviral activity. The results reveal that curcumin possesses insignificant inhibitory activity against EV71 infection in RD cells [half‐maximal effective concentration (EC50) >200 µg mL−1] but exhibits high cytotoxicity toward RD cells (half‐maximal cytotoxic concentration (CC50) <13 µg mL−1). The EC50 (0.2 µg mL−1) and CC50 (452.2 µg mL−1) of Cur‐CQDs are >1000‐fold lower and >34‐fold higher, respectively, than those of curcumin, demonstrating their far superior antiviral capabilities and high biocompatibility. In vivo, intraperitoneal administration of Cur‐CQDs significantly decreases mortality and provides protection against virus‐induced hind‐limb paralysis in new‐born mice challenged with a lethal dose of EV71.

show abstract

Monocarbonyl Analogs of Curcumin with Potential to Treat Colorectal Cancer

Clariano

Marques

Vaz

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

Curcumin has a plethora of biological properties, making this compound potentially effective in the treatment of several diseases, including cancer. However, curcumin clinical use is compromised by its poor pharmacokinetics, being crucial to find novel analogs with better pharmacokinetic and pharmacological properties. Here, we aimed to evaluate the stability, bioavailability and pharmacokinetic profiles of monocarbonyl analogs of curcumin. A small library of monocarbonyl analogs of curcumin 1a-q was synthesized. Lipophilicity and stability in physiological conditions were both assessed by HPLC-UV, while two different methods assessed the electrophilic character of each compound monitored by NMR and by UV-spectroscopy. The potential therapeutic effect of the analogs 1a-q was evaluated in human colon carcinoma cells and toxicity in immortalized hepatocytes. Our results showed that the curcumin analog 1e is a promising agent against colorectal cancer, with improved stability and efficacy/safety profile.

show abstract

Antiviral potential of curcumin

Cited by 206 publications

References 123 publications

Polymersome‐assisted delivery of curcumin: A suitable approach to decrease cancer stemness markers and regulate miRNAs expression in HT29 colorectal cancer cells

Polymersome‐assisted delivery of curcumin: A suitable approach to decrease cancer stemness markers and regulate miRNAs expression in HT29 colorectal cancer cells

High Amplification of the Antiviral Activity of Curcumin through Transformation into Carbon Quantum Dots

Monocarbonyl Analogs of Curcumin with Potential to Treat Colorectal Cancer

Contact Info

Product

Resources

About