Antiviral Properties of Alginate-Based Biomaterials: Promising Antiviral Agents against SARS-CoV-2

Serrano‐Aroca, Ãngel; Ferrandis-Montesinos, María; Wang, Ruibing

doi:10.1021/acsabm.1c00523

Cited by 67 publications

(44 citation statements)

References 87 publications

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“…In addition, alginate-based materials were tested on diverse types of viruses, and they were found to have little or no cytotoxic effect. The antiviral mechanism of action is mainly attributed to viral aggregation and viral inhibition through the interconnection of alginate-based materials with components of the viral load [ 99 ]. Therefore, these studies suggest great opportunities for future research in the field of alginate-based biomaterials with antiviral properties against SARS-CoV-2 [ 96 , 100 , 101 ].…”

Section: Covid-19 Consequences In Cvd Patientsmentioning

confidence: 99%

From Biomedical Applications of Alginate towards CVD Implications Linked to COVID-19

et al. 2022

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In the past year, researchers have focused their attention on developing new strategies for understanding how the coronavirus affects human health and developing novel biomaterials to help patients with cardiovascular disease, which greatly increases the risk of complications from the virus. Natural biopolymers have been investigated, and it has been proven that alginate-based materials have important features. This review presents an overview of alginate-based materials used for developing innovative biomaterial platforms for biomedical applications to mitigate the effects of the coronavirus. As presented in this review, COVID-19 affects the cardiovascular system, not only the lungs. The first part of the review presents an introduction to cardiovascular diseases and describes how they have become an important problem worldwide. In the second part of the review, the origin and unique properties of the alginate biopolymer are presented. Among the properties of alginate, the most important are its biocompatibility, biodegradability, low cost, nontoxicity, unique structure, and interesting features after chemical modification. The third section of the review illustrates some of the functions of alginate in biomedical, pharmaceutical, and drug delivery applications. Researchers are using alginate to develop new devices and materials for repairing heart tissues that have been damaged by the coronavirus. Further, insights regarding how cardiovascular disease affects COVID-19 patients are also discussed. Finally, we conclude the review by presenting a summary of the impacts of COVID-19 on cardiovascular patients, their implications, and several hypothetical alginate-based treatments for infected patients.

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Section: Covid-19 Consequences In Cvd Patientsmentioning

confidence: 99%

From Biomedical Applications of Alginate towards CVD Implications Linked to COVID-19

et al. 2022

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“…Alginate also forms complexes with several polycations like chitosan, polyenimine, or essential peptides like polyarginine and polyarginine. Recently, alginate and its related biomaterials were tested on 17 types of viruses (Serrano-Aroca et al, 2021a). These materials showed inhibitory activity against human immunodeficiency virus, herpes simplex virus type 1 and type 2, hepatitis A, B, and C viruses, rubella virus, and rabies virus.…”

Section: Alginatementioning

confidence: 99%

Potential Application of Bionanoparticles to Treat Severe Acute Respiratory Syndrome Coronavirus-2 Infection

Debnath

Srivastava

2022

Front. Nanotechnol.

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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a contagious virus that spreads exponentially across the world, resulting in serious viral pneumonia. Several companies and researchers have put their tremendous effort into developing novel vaccines or drugs for the complete eradication of COVID-19 caused by SARS-CoV-2. Bionanotechnology plays a vital role in designing functionalized biocompatible nanoparticulate systems with higher antiviral capabilities. Thus, several nanocarriers have been explored in designing and delivering drugs and vaccines. This problem can be overcome with the intervention of biomaterials or bionanoparticles. The present review describes the comparative analysis of SARS infection and its associated etiological agents. This review also highlighted some nanoparticles that have been explored in the treatment of COVID-19. However, these carriers elicit several problems once they come in contact with biological systems. Often, the body’s immune system treats these nanocarriers as foreign particles and antigens. In contrast, some bionanoparticles are highlighted here with their potential application in SARS-CoV-2. However, bionanoparticles have demonstrated some drawbacks discussed here with the possible outcomes. The scope of bioinspired nanoparticles is also discussed in detail to explore the new era of research. It is highly essential for the effective delivery of these nanoparticles to the target site. For effective management of SARS-CoV-2, different delivery patterns are also discussed here.

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“…For instance, the purified alginic acid does not inhibit SARS-CoV-2, but it may bind to SARS-CoV-2 3CLpro and effectively impede the binding of SARS-CoV-2 -S1 protein with ACE2 (IC 50 56.06 µg/mL) and thus have the potential to block SARS-CoV-2 infection. Serrano-Aroca et al (2021) advocated the use of alginate-based biomaterials for the management of COVID-19 [207]. Indeed, these biomaterials exhibited antiviral activity against a wide range of viruses, including the HIV-1 [208][209][210], hepatitis A, B, and C viruses [210][211][212][213], Sindbis virus [213], RABV [214], rubella virus [215], influenza virus [216], HSV-1 and 2 [74,76,77,101,213,217], poliovirus type 1 [213,218], potato virus X [219], tobacco mosaic virus [220,221], and murine norovirus [211,212].…”

Section: Alginic Acidsmentioning

confidence: 99%

“…In contrast, oligosaccharides, such as those derived from carrageenan by chemical and enzymatic treatment, can have considerably higher bioavailability and biological activity [303]. An octasaccharide generated from a sulfated polymannuroguluronate (SPMG) could inhibit HIV adsorption [207] by targeting CD4 in lymphocytes [304]. According to new research [40], the administration of LMWH reduces mortality in individuals with severe coronavirus coagulopathy.…”

Section: Relationship Between Structures Of Sulfated Polysaccharide A...mentioning

confidence: 99%

Antiviral Strategies Using Natural Source-Derived Sulfated Polysaccharides in the Light of the COVID-19 Pandemic and Major Human Pathogenic Viruses

Ray

Ali

Jana

et al. 2021

Viruses

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Only a mere fraction of the huge variety of human pathogenic viruses can be targeted by the currently available spectrum of antiviral drugs. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak has highlighted the urgent need for molecules that can be deployed quickly to treat novel, developing or re-emerging viral infections. Sulfated polysaccharides are found on the surfaces of both the susceptible host cells and the majority of human viruses, and thus can play an important role during viral infection. Such polysaccharides widely occurring in natural sources, specifically those converted into sulfated varieties, have already proved to possess a high level and sometimes also broad-spectrum antiviral activity. This antiviral potency can be determined through multifold molecular pathways, which in many cases have low profiles of cytotoxicity. Consequently, several new polysaccharide-derived drugs are currently being investigated in clinical settings. We reviewed the present status of research on sulfated polysaccharide-based antiviral agents, their structural characteristics, structure–activity relationships, and the potential of clinical application. Furthermore, the molecular mechanisms of sulfated polysaccharides involved in viral infection or in antiviral activity, respectively, are discussed, together with a focus on the emerging methodology contributing to polysaccharide-based drug development.

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Antiviral Properties of Alginate-Based Biomaterials: Promising Antiviral Agents against SARS-CoV-2

Cited by 67 publications

References 87 publications

From Biomedical Applications of Alginate towards CVD Implications Linked to COVID-19

From Biomedical Applications of Alginate towards CVD Implications Linked to COVID-19

Potential Application of Bionanoparticles to Treat Severe Acute Respiratory Syndrome Coronavirus-2 Infection

Antiviral Strategies Using Natural Source-Derived Sulfated Polysaccharides in the Light of the COVID-19 Pandemic and Major Human Pathogenic Viruses

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