Antiviral properties of chalcones and their synthetic derivatives: a mini review

Marinov, R; Маркова, Н.; Krumova, Stefka; Yotovska, Kamelia; Zaharieva, Maya M.; Genova-Kalоu, Petia

doi:10.3897/pharmacia.67.e53842

Cited by 19 publications

(16 citation statements)

References 118 publications

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“…A docking study suggested that the antiviral activity of (190) might depend on its strong binding affinity to tobacco mosaic virus coat protein (TMV-CP). There are several other reports on antiviral properties of synthetic chalcone derivatives available in the literature to date, including a few excellent review articles on this topic [108][109][110].…”

Section: Antiviral Activitymentioning

confidence: 99%

Chalcones: Synthetic Chemistry Follows Where Nature Leads

et al. 2021

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Chalcones belong to the flavonoid class of phenolic compounds. They form one of the largest groups of bioactive natural products. The potential anticancer, anti-inflammatory, antimicrobial, antioxidant, and antiparasitic properties of naturally occurring chalcones, and their unique chemical structural features inspired the synthesis of numerous chalcone derivatives. In fact, structural features of chalcones are easy to construct from simple aromatic compounds, and it is convenient to perform structural modifications to generate functionalized chalcone derivatives. Many of these synthetic analogs were shown to possess similar bioactivities as their natural counterparts, but often with an enhanced potency and reduced toxicity. This review article aims to demonstrate how bioinspired synthesis of chalcone derivatives can potentially introduce a new chemical space for exploitation for new drug discovery, justifying the title of this article. However, the focus remains on critical appraisal of synthesized chalcones and their derivatives for their bioactivities, linking to their interactions at the biomolecular level where appropriate, and revealing their possible mechanisms of action.

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Section: Antiviral Activitymentioning

confidence: 99%

Chalcones: Synthetic Chemistry Follows Where Nature Leads

et al. 2021

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“…TAT/pTEFB [48,49] CDK9 activators Chalcone, Amt-87 pTEFB [50,51] Unclassified Anti-oxidant Auranofin NF-kappaB [52,53] AKT modulators Disulfiram, 57704 [54,55] S1P1 agonist SEW2871 NF-kappaB [56] Protein phosphatase 1 SMAPP1 pTEFb [57] SMAC mimetics SBI-0637142 NF-kappaB Macroautophagy-related genes (ATGs) were first identified in yeasts by Yoshinori Ohsumi, who was awarded the 2016 Nobel Prize in Physiology or Medicine. Thus far, macroautophagy is the best characterized form of autophagy and is hereafter referred to as autophagy.…”

Section: Referencesmentioning

confidence: 99%

Selective elimination of host cells harboring replication-competent human immunodeficiency virus reservoirs: a promising therapeutic strategy for HIV cure

Zaongo¹,

Ma²,

Song³

et al. 2021

Chinese Medical Journal

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Many seminal advances have been made in human immunodeficiency virus (HIV)/AIDS research over the past four decades. Treatment strategies, such as gene therapy and immunotherapy, are yielding promising results to effectively control HIV infection. Despite this, a cure for HIV/AIDS is not envisioned in the near future. A recently published academic study has raised awareness regarding a promising alternative therapeutic option for HIV/AIDS, referred to as “selective elimination of host cells capable of producing HIV” (SECH). Similar to the “shock and kill strategy,” the SECH approach requires the simultaneous administration of drugs targeting key mechanisms in specific cells to efficiently eliminate HIV replication-competent cellular reservoirs. Herein, we comprehensively review the specific mechanisms targeted by the SECH strategy. Briefly, the suggested cocktail of drugs should contain (i) latency reversal agents to promote the latency reversal process in replication-competent reservoir cells, (ii) pro-apoptotic and anti-autophagy drugs to induce death of infected cells through various pathways, and finally (iii) drugs that eliminate new cycles of infection by prevention of HIV attachment to host cells, and by HIV integrase inhibitor drugs. Finally, we discuss three major challenges that are likely to restrict the application of the SECH strategy in HIV/AIDS patients.

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“…In a study with compounds isolated from bioassay-guided fractionation of the ethanol extract of P. hispidum leaves and tested against axenic amastigotes of L. (L.) amazonensis, two chalcones demonstrated strong activities with IC50 values of 0.8 µM (30) and 8 µM (31), and moderate toxicity against peritoneal macrophages (CC50 = 1.6 and 18.2 µM, respectively) [48]. Chalcones are a group of naturally occurring chemical compounds that have different bioactivities, including antimicrobial [75], antifungal [76], anticancer [77], antiviral [78], anti-inflammatory [79] and antiparasitic [80] activities. Different studies with Leishmania reported that the target organelle of chalcones is the parasite mitochondria, where they inhibit its function [81].…”

Section: Isolated Compoundsmentioning

confidence: 99%

Antileishmanial Activity of the Genus Piper: A Systematic Review

Macêdo

Castro

Silva

2021

EJMP

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Background: Leishmaniases are anthropozoonotic vector-borne diseases, caused by the protozoan Leishmania spp. These diseases have significant morbidity and mortality worldwide and, as there are currently no vaccines available for their treatment, chemotherapy remains the mainstay for anti-leishmanial therapeutics. However, the severe side effects, reduced bioavailability, high cost and chemoresistance, amongst other problems, limit the use of available drugs. In recent years, natural compounds have shown promise as anti-leishmanial agents, especially those extracted from medicinal plants. The genus Piper has been used in traditional medicine and widely explored for its biological properties and bioactive phytocompounds. Aim: The aim of this study was to conduct a systematic literature review of the biological activity of the genus Piper against the etiological agents of leishmaniasis, to provide a perspective for effective and safe phytotherapics, new drugs or potentially active prototype chemical substances. Methodology: This systematic review was prepared in accordance with PRISMA guidelines. The databases used for this review were SciELO, Pubmed, ScienceDirect and Google Scholar, using a temporal profile of 2009 to 2020. Conclusion: In this review, we summarize a wide range of isolated compounds, extracts and essential oils of the genus Piper that are worth screening given their potential for development as effective anti-leishmanial drugs.

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Antiviral properties of chalcones and their synthetic derivatives: a mini review

Cited by 19 publications

References 118 publications

Chalcones: Synthetic Chemistry Follows Where Nature Leads

Chalcones: Synthetic Chemistry Follows Where Nature Leads

Selective elimination of host cells harboring replication-competent human immunodeficiency virus reservoirs: a promising therapeutic strategy for HIV cure

Antileishmanial Activity of the Genus Piper: A Systematic Review

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