Antiviral property and mode of action of a sulphated polysaccharide from Sargassum patens against herpes simplex virus type 2

Zhu, Wen; Chiu, Lawrence C.M.; Ooi, Vincent E.C.; Chan, Paul K.S.; Ang, Put O.

doi:10.1016/j.ijantimicag.2004.02.022

Cited by 73 publications

(42 citation statements)

References 24 publications

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“…Generally, the biological activity of polysaccharides from marine algae is related to the molecular size, type of sugar, sulfate content, type of linkage and molecular geometry which are known to have a role in their activities (Zhu et al, 2004). Besides their well attested anti-coagulant and anti-thrombotic activity, they act on the inflammation and immune systems, have anti-proliferative and antiadhesive effect on cells, protect cells from viral infection, and can interfere with mechanisms involved in fertilization.…”

Section: Other Metabolites From Seaweedsmentioning

confidence: 99%

“…This fact suggests that marine algae, like photosynthesizing plants, have anti-oxidative mechanisms and compounds which act as anti-oxidant agents. At the same time, several species of seaweeds have also been found to produce or contain polysaccharides, glycoproteins or other secondary metabolites with antimicrobial (Cox et al, 2009;Q1 Gupta, Rajauria, & Abu-Ghannam, 2010a), antitumoral (Koyanagi, Tanigawa, Nakagawa, Soeda, & Shimeno, 2003;Zubia et al, 2009) or anti-viral activity (Artan et al, 2008;Hemmingson, Falshaw, Furneaux, & Thompson, 2006;Zhu, Chiu, Ooi, Chan, & Angjr, 2004;. Among all the three types highest phytochemical content have been reported from brown seaweeds (Seafoodplus, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Bioactive potential and possible health effects of edible brown seaweeds

Gupta¹,

Abu‐Ghannam²

2011

Trends in Food Science & Technology

508

292

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Marine macroalgae (seaweeds) are rich in bioactive compounds that could potentially be exploited as functional ingredients for both human and animal health applications. Despite the intensive efforts that are being made to isolate and identify new compounds with potential medicinal, health or pharmaceutical activities, very few compounds with real potency are available. Bioactive compounds that are most extensively researched include sulfated polysaccharides, phlorotannins and diterpenes. These compounds have been reported to possess strong anti-viral, anti-tumor and anti-cancer properties. At the same time, the prebiotic health potential of the polysaccharides from seaweeds is also increasingly being studied either by feeding whole seaweeds or purified polysaccharides to laboratory and farm animals. The present review discusses the pharmaceutical, health and research potential of different bioactive compounds present in brown seaweeds.

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Section: Other Metabolites From Seaweedsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioactive potential and possible health effects of edible brown seaweeds

Gupta¹,

Abu‐Ghannam²

2011

Trends in Food Science & Technology

508

292

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“…Therefore, the water extracts of C. myrica also exhibit antiviral effect on post attachment stages of HSV-1 to the Vero cells, probably on internalization of virus to the cells because we have done this phase of study at 37ºC. Meanwhile, in one study which evaluated the antiviral activity of sulphated polysaccharides from Sargassum patens, a brown alga, against HSV-2, suggested that the antiviral mode of action of purified sulphated polysaccharide of that alga could be ascribed to the inhibition of virus adsorption (Zhu et al, 2004). Also, in another study the antiviral effect of diterpens from Dictyota pfaffi a Brazilian brown alga, on HSV-1 was evaluated and the results indicated that the diterpenes affected an early step of the replicative cycle (Barbosa et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of in vitro antiviral activity of a brown alga (Cystoseira myrica) from the Persian Gulf against herpes simplex virus type 1

Keivan¹,

i²,

Fouladv³

et al. 2007

Afr. J. Biotechnol.

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The hot water extract of a brown marine alga, Cystoseira myrica, from the Persian Gulf was evaluated as an antiviral compound against KOS strain of HSV-1 in cell culture. The extract exhibited antiviral activity against herpes simplex virus type 1 (HSV-1) not only during absorption of virus to the cells, but also on post attachment stages of virus replication. The water extract of C. myrica was sterilized by filtration and autoclaving, respectively. The IC 50 for filtered extract was 99 µg/ml and the IC 50 for autoclaved extract was 125 µg/ml. Based on resulted selectivity index (SI) values of the extracts, which were 33.4 and 28.2 for filtered and autoclaved extracts, respectively, we found that the antiviral compound(s) in the water extract of C. myrica to be heat stable. Also, the SI values for inhibition of the post attachment stages of HSV-1 replication were 23.1 and 21.7 for filtered and autoclaved extracts, respectively. The IC 50 in this phase of study were 143 and 162 µg/ml for filtered and autoclaved extracts, respectively. Therefore, C. myrica could be a good candidate as a natural source for anti-HSV-1 compound(s) isolation.

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“…The inhibitory effects of 3,4-DCQA and its derivatives (LS-1 to LS-9) on the replication of RSV in HEp-2 cells were tested by the plaque reduction assay, which was performed according to the method described previously with some modifications [30]. Briefly, monolayer of HEp-2 cells was grown on 12-well plate.…”

Section: Plaque Reduction Assaymentioning

confidence: 99%

Esterification of the Free Carboxylic Group in 3,4-di-O-caffeoylquinic Acid Enhances the Inhibition Activity against Respiratory Syncytial Virus (RSV)

Wu¹,

Tang²

2015

Med chem

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Based on molecular docking analysis, nine alkyl 3,4-di-O-caffeoyl-quinates have been designed. Started from 3,4-di-O-caffeoylquinic acid (3,4-DCQA), all the compounds have been synthesized using thionylchloride as coupling reagent with yields of 56%-72%. By applying plaque reduction assay, the anti-respiratory syncytial virus (RSV) activities of all the compounds were evaluated. The IC 50 values of all the derivatives were 2.9 to 7.8 times less than that of 3,4-DCQA itself. Isopropyl 3,4-Di-O-caffeoyl quinate (LS-4) was confirmed as the most active compound with IC 50 value of 0.3 µM. It was indicated that hydrophobic groups with 2 to 4 carbon chain length were optimal for the enhancement of anti-RSV activity. Interestingly, all the derivatives showed greater cytotoxicity than 3,4-DCQA. Except LS-5, LS-6 and LS-9, all the derivatives have less toxicity than ribavirin. Furthermore, the stabilities of LS-4 in water, artificial gastric juice (AGJ), and artificial intestinal juice were evaluated, respectively. It was shown that LS-4 is stable in AGJ with the hydrolysis rate of 24.9% after 6 hours incubation at 37°C.

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Antiviral property and mode of action of a sulphated polysaccharide from Sargassum patens against herpes simplex virus type 2

Cited by 73 publications

References 24 publications

Bioactive potential and possible health effects of edible brown seaweeds

Bioactive potential and possible health effects of edible brown seaweeds

Evaluation of in vitro antiviral activity of a brown alga (Cystoseira myrica) from the Persian Gulf against herpes simplex virus type 1

Esterification of the Free Carboxylic Group in 3,4-di-O-caffeoylquinic Acid Enhances the Inhibition Activity against Respiratory Syncytial Virus (RSV)

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