Antiviral sesquiterpenes from leaves of Nicotiana tabacum

Shang, Shan‐Zhai; Zhao, Wei; Xu, Xingmeng; Sun, Handong; Pu, Jian‐Xin; Liu, Zhihua; Ming-ming, Miao; Yongkuan, Chen; Yang, Guangyu

doi:10.1016/j.fitote.2015.11.004

Cited by 41 publications

(15 citation statements)

References 13 publications

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“…It also used as a vermifuge [8-10]. Antimicrobial potentiality of N. tabacum against diverse types of human and animal pathogens has been documented in some studies [11-13]. As yet however, antimicrobial activity and chemical analysis of N. tabacum in Ethiopia is not well studied [14].…”

Section: Introductionmentioning

confidence: 99%

In vitro Antibacterial Activity and Phytochemical Analysis of Nicotiana tabacum L. Extracted in Different Organic Solvents

Ameya¹,

Manilal²,

Merdekios³

2017

TOMICROJ

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Background:Controlling infectious disease using medicinal plants is the oldest healthcare known to mankind. Regardless of the enormous advances observed in modern medicine, medicinal plants are still playing vital roles. However, only a small proportion of medicinal plants are examined for bioactive compounds which may vary in different factors. This study aimed to evaluate phytochemical constituent and antimicrobial activities of Nicotiana tabacum L. extracted by different solvents against three set of bacteria.Methods: Nicotiana tabacum L. was collected from the Western Ethiopia and extracted in seven organic solvents. An in-vitro anti-bacterial activity of plant extracts was carried out by agar well diffusion assay against microbial type culture collection of human pathogens, clinical bacterial isolates, and biofilm forming bacteria. Gas Chromatographic and Mass Spectroscopic (GC-MS) analysis was used to determine the phytochemical constituents.Results:Antimicrobial activities of plant extract vary by extraction solvents; and ethyl acetate based extracts showed better antimicrobial activities. Of the experimental organisms, biofilm forming uropathogens were the most sensitive while clinical isolates were quite resistant. Analysis of the active ethyl acetate extract by GC-MS evinced a mixture of five volatile compounds; and Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S) was the major compound detected. The overall results of the present study revealed that N. tabacum L extract has high antimicrobial activities against biofilm forming uropathogens.Conclusion:High antimicrobial activity was observed in ethyl acetate extract of N. tabacum against the biofilm forming bacteria whereas the clinically isolated bacteria were the most resistant group. The antibacterial property demonstrated could be due to Pyridine, 3-(1-methyl-2-pyrrolidinyl)-(S) with a broad spectrum of activity.

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Section: Introductionmentioning

confidence: 99%

In vitro Antibacterial Activity and Phytochemical Analysis of Nicotiana tabacum L. Extracted in Different Organic Solvents

Ameya¹,

Manilal²,

Merdekios³

2017

TOMICROJ

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“…Nicosesquiterpene A and B are novel sesquiterpenes, which showed inhibition rates of 36.7% and 45.6%, respectively (Shen et al, 2016). Other novel sesquiterpenes such as nicotianasesterpenes A and B or tabasesquiterpenes A-C (Shang et al, 2016) were more efficient than NNM, showing inhibition rates in the range of 34-35%. Another eight sesquiterpenes led to inhibition rates in the range of 18-29% Shang et al, 2016).…”

Section: Natural Productsmentioning

confidence: 98%

Chemical Outbreak for Tobacco Mosaic Virus Control

Luvisi¹,

Panattoni²,

Materazzi³

et al. 2017

IJAB

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Tobacco mosaic virus (TMV) represents a paradigm in virology, and its control may open the way to effective treatment against phytoviruses. However, the use of chemicals to eliminate the virus from infected plants is very difficult. In this state of the art survey we include trials on a) natural compounds derived from organisms, b) synthetic compounds and c) plant or microorganism extracts, from 2006 to 2015. Plants have been the main source of natural products for anti-TMV tests in the last ten years, and Nicotiana tabacum was the main focus of research, particularly between 2014-2015. Since 2012, there has been a great increase in publications (+45%) and identified compounds (+241%). Between 2012-2015, an average of 31 papers were published and 140 compounds were tested each year, compared to 9 papers and 26 compounds in 2006-2011. Unfortunately, there is little information on the action mechanisms of newly discovered or modified compounds. Cross references to the basic structure of compounds is provided in this review. This chemical outbreak this massive interest in chemical solutions to TMV could be due to the increasing availability of instruments for the analysis of organic compounds. Alternatively Another explanation could be that the chemistry advances in synthesis, which have provided countless drugs with potential benefits for TMV control, have overwhelmed overloaded the plant pathology screening needed to discriminate between compounds and to provide useful agrochemicals for farmers.

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“…Tabasesquiterpene B ( 435 ) (Shang et al, 2016 ), nicosesquiterpenes A ( 436 ) and B ( 437 ) (Shen et al, 2016 ) were obtained from leaves of Nicotiana tabacum (Yunnan, China), and showed anti-TMV activities with 35.2, 36.7, and 45.6% inhibition at 20 μM, respectively, better than ningnanmycin. Ananasin A ( 438 ), a flavonolignan, was discovered from Ananas comosus (Hainan, China), and was active against S. aureus and E. coli with the same MIC value of 0.156 μg/mL (ciprofloxacin, MIC 0.156 μg/mL) (Huang et al, 2015 ).…”

Section: Terrestrial Plantsmentioning

confidence: 99%