Antiviral Triterpenoid Saponins from the Roots of Ilex asprella

Abstract

Two new sulfur-containing triterpenoid saponins, asprellanosides A (1) and B (2), were isolated from the roots of Ilex asprella, together with 10 known compounds (3-12). An in vitro anti-HSV-1 activity test of the isolates (1-4, 6-7, and 9-12) showed that only asprellanoside A (1) and oblonganoside H (6) exhibited anti-HSV-1 activity with TIC values of 0.14 and 0.18 mM, respectively.

Bioactive glycosides from the roots ofIlex asprella

“…The HMBC spectrum (Table 1, Figure 3) showed correlation peaks between the H-1 0 ( H 4.68) of arabinose and C-3 ( C 106.4) of the aglycone, as well as the H-1 00 ( H 6.37) of glucose and C-28 ( C 95.8) of the aglycone, affirming that the glycosidation positions of b-arabinose and b-glucose are located on C-3 and C-28 of the triterpenoid sapogenin, respectively. These data were similar to those of asprellanoside A (Zhou et al 2012). However, the formula weight of 1 was 80 Da greater than that of asprellanoside A, which can be ascribed to a SO 3 H group.…”

“…According to a previous report, only two triterpenoids from the roots exhibited anti-HSV-1 activity (Zhou et al 2012). Our results demonstrate that both compound 1 and 2 have antiviral activity against the H1N1 influenza virus in A549 cells.…”

The roots of Ilex asprella extract lessens acute respiratory distress syndrome in mice induced by influenza virus

“…From a literature review in pharmacological reports of IA, we found that many researches are focused on its hydroalcoholic extract, only Zhou et al reported that triterpenoid saponins from IA have anti-HSV-1 activity (Zhou et al, 2012). We hypothesize that total saponins may be the active ingredients in antiinfluenza virus.…”

Synthesis of Lanostane‐Type Triterpenoid N‐Glycosides and Their Cytotoxicity against Human Cancer Cell Lines

“…Triterpenoid glycosides have been reported to possess various biological activities, including anti‐inflammatory, antitumor promoter, antiviral, and cytotoxic activities. [] Naturally occurring triterpenoid glycosides usually have an O ‐bond between the aglycone (triterpenoids) and sugar moieties. Recently, N ‐glycosides were synthesized from steroids and reported to have cytotoxicity against human cancer cell lines.…”