Antivitamin K prevents heterotopic ossification after hip arthroplasty in diffuse idiopathic skeletal hyperostosis: A retrospective study in 67 patients

Guillemin, Françis; Mainard, Didier; Rolland, HervÉ; Delagoutte, J. P.

doi:10.3109/17453679508995504

Cited by 27 publications

(5 citation statements)

References 18 publications

(19 reference statements)

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“…These patients, however, may be at a higher risk of heterotopic ossification postoperatively. 1,24 The current investigation confirmed that hip arthroscopic preservation surgery hip is of great promise for individuals with extraspinal DISH of the hip joint.…”

Section: Discussionsupporting

confidence: 73%

Clinical Outcomes After Arthroscopic Treatment of Extraspinal Diffuse Idiopathic Skeletal Hyperostosis (DISH) Involving the Hip Joint

Yang,

Zhang,

Huang

et al. 2024

CARTILAGE

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Objective The hip joint can be affected by extraspinal diffuse idiopathic skeletal hyperostosis (DISH). This study aimed to compare the clinical characteristics of hips with DISH to those with mixed-type femoroacetabular impingement symptoms (FAIS). In addition, patient-reported outcome (PRO) scores were reported among patients with DISH involving the hip joint who underwent arthroscopic treatment. Methods A retrospective analysis was performed using data from patients who underwent hip arthroscopy between 2017 and 2021. Patients who had a preoperative diagnosis of extraspinal DISH of the hip joint and postoperative Hip Outcome Score–Activities of Daily Living (HOS-ADL), Hip Outcome Score–Sports Subscale (HOS-SSS), International Hip Outcome Tool 12-component form (iHOT-12), modified Harris Hip Score (mHHS) and visual analog scale (VAS) for pain scores were enrolled in the study. The patients’ characteristics were compared with those of a control group (1:2) consisting of mixed-type patients with FAIS. The control group was matched in terms of age, sex, body mass index (BMI), and symptom duration. Results Eleven hips (0.87%) with extraspinal DISH (study group) were matched to 22 FAIS hips (control group). All the patients were male. The mean age of patients was 42.0 ± 8.0 in the study group. The study group was characterized by a larger preoperative alpha angle (79.1 ± 6.8 vs 64.8 ± 9.7, P < .001), lateral center-edge angle (LCEA) (49.7 ± 6.0 vs 40.7 ± 3.2, P < .001), and postoperative LCEA (36.6 ± 3.0 vs 34.2 ± 2.0, P = .013). In addition, a higher proportion of acetabular (81.8% vs 31.8%, P = .007) and femoral head chondral lesions (45.5% vs 9.1%, P = .016). Cartilage damage has the potential to affect the prognosis of arthroscopic treatment. Nevertheless, at the final follow-up, patients with DISH experienced a significant increase in range of motion (ROM), notable enhancements in all PROs, and favorable rates of minimal clinically important difference (MCID) for the PROs. Conclusion The occurrence of DISH in the hip joint is considerably infrequent, characterized by hip pain and limited ROM. Despite increased alpha angle and LCEA, and more acetabular and femoral head chondral damage noted at the time hip arthroscopy, patients with DISH observed a significant improvement in ROM, notable enhancements in all PROs, and favorable rates of MCID for the PROs.

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Section: Discussionsupporting

confidence: 73%

Clinical Outcomes After Arthroscopic Treatment of Extraspinal Diffuse Idiopathic Skeletal Hyperostosis (DISH) Involving the Hip Joint

Yang,

Zhang,

Huang

et al. 2024

CARTILAGE

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“…67 Due to the propensity of patients with DISH to develop heterotopic ossification following joint replacement surgeries, it has been suggested to adopt preventive measures such as the use of NSAIDs and/or irradiation in the perioperative period. [68][69][70] However, the prevention or inhibition of soft tissue ossification has not been investigated systematically in patients with DISH. Therapeutic studies in DISH are hampered by several reasons.…”

Section: Therapeutic Considerationsmentioning

confidence: 99%

Diffuse idiopathic skeletal hyperostosis (DISH): where we are now and where to go next

Mader¹,

et al. 2017

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“…There is substantial case-control evidence that combined nonsteroidal antiinflammatory medications and local radiation therapy may have an additive or synergistic beneficial effect in the prevention of recurrence as compared with the effect of monotherapy with either modality alone [53][54][55][56] . Numerous other agents, including the early bisphosphonate etidronate, have been studied in human and animal trials of heterotopic ossification prevention, with varying levels of success and supporting evidence [57][58][59][60][61][62][63][64][65][66] .…”

Section: Primary and Secondary Prophylaxis Against Heterotopic Ossifimentioning

confidence: 99%

Heterotopic Ossification Following Traumatic and Combat-Related Amputations

Potter

Burns

Lacap

et al. 2007

The Journal of Bone & Joint Surgery

232

130

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Heterotopic ossification following trauma-related amputation is more common than the literature would suggest, particularly following amputations that are performed within the initial zone of injury and those that are due to blast injuries. Many patients are asymptomatic or can be successfully managed with modification of the prosthesis. For patients with refractory symptoms, surgical excision is associated with low recurrence rates and decreased medication requirements, with acceptable complication rates.

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Antivitamin K prevents heterotopic ossification after hip arthroplasty in diffuse idiopathic skeletal hyperostosis: A retrospective study in 67 patients

Cited by 27 publications

References 18 publications

Clinical Outcomes After Arthroscopic Treatment of Extraspinal Diffuse Idiopathic Skeletal Hyperostosis (DISH) Involving the Hip Joint

Clinical Outcomes After Arthroscopic Treatment of Extraspinal Diffuse Idiopathic Skeletal Hyperostosis (DISH) Involving the Hip Joint

Diffuse idiopathic skeletal hyperostosis (DISH): where we are now and where to go next

Heterotopic Ossification Following Traumatic and Combat-Related Amputations

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