Antroduodenal Manometry in Children and Adults with Severe Nonulcer Dyspepsia

Abstract

Signs, symptoms, and discrete manometric abnormalities of childhood nonulcer dyspepsia resembled those of adult nonulcer dyspepsia. Manometric findings in nonulcer dyspepsia resembled those reported in chronic intestinal pseudo-obstruction, suggesting that these conditions are on a continuum of enteric neuromuscular diseases.

Chronic vomiting in children: New insights into diagnosis

“…Clusters of small intestinal non-migrating or uncoordinated phasic activity in patients and control subjects may also be seen in functional dyspepsia and post-fundoplication states, and may be secondary to physical or emotional stress [32]. Due to the degree of overlap between these groups of children and control subjects, caution should be used in the interpretation of qualitative abnormalities in MMC.…”

“…It is invasive, as it requires placement of a nasoduodenojejunal catheter, usually under fluoroscopic or endoscopic guidance. Antroduodenal manometry is most frequently used in the diagnostic evaluation of pseudo-obstruction but has also been used to investigate the motility patterns associated with gastroparesis, rumination syndrome, CV, non-ulcer dyspepsia, and other functional bowel disorders [31][32][33].…”

Psychosocial factors and childhood recurrent abdominal pain

“…The role of motility in the pathophysiology of irritable bowel syndrome, non‐ulcer dyspepsia, and functional abdominal pain in children remains unclear. Abnormal gastric electrical rhythm, 28 delayed gastric emptying, 29 and disturbances in antroduodenal motility 30 have been shown in some children, but recent data have demonstrated a poor correlation between pain and gastrointestinal motility 8 …”

Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia

“…A study of 34 children and 35 adults with FD found a majority with abnormal motility with a neuropathic pattern observed most commonly [110] . Several studies of antroduodenal motility also demonstrate abnormalities in adults with FD [111,112] , but symptoms, intestinal dysmotility, and gastric emptying delays are not clearly correlated [112] .…”

“…Although the water load test may not be useful for identification of pediatric FD due to suboptimal sensitivity, children diagnosed with FD often have abnormal test results [36] . In a controlled study by Schurman et al [36] , 68 pediatric patients with FGIDs and 26 healthy children completed the Behavioral Assessment Scale for Children- [36] 28 FD Hoffman et al [37] 15 FD Chitkara et al [38] 101 CAP Anderson et al [39] Gastric barostat 16 FD Hoffman et al [47] 10 RAP, 10 IBS Di Lorenzo et al [48] Electromechanical function Gastric emptying breath test 28 FD Hoffman et al [37] 15 FD Chitkara et al [38] Gastric emptying scintigraphy 57 FD Chitkara et al [76] 30 FD Friesen et al [77] Gastric Emptying ultrasound 41 FD Devanarayana et al [78] 42 FD Boccia et al [79] Accommodation ultrasound 20 RAP Olafsdottir et al [94] 20 RAP Olafsdottir et al [95] 20 non-ulcer dyspepsia Cucchiara et al [96] SPECT 15 FD Chitkara et al [38] Electrogastrogram 30 FD Friesen et al [77] 15 FD Chen et al [106] 7 non-ulcer dyspepsia Di Lorenzo et al [114] Antroduodenal manometry 11 non-ulcer dyspepsia Cucchiara et al [109] 34 non-ulcer dyspepsia Di Lorenzo et al [110] 7 non-ulcer dyspepsia Di Lorenzo et al [114] Wireless motility capsule 22 mixed upper GI symptoms Green et al [118] [138] Citalopram 25 RAP Campo et al [140] Famotidine 25 RAP with dyspepsia See et al [148] Omeprazole 169 FD Dehghani et al [149] Cisapride 10 non-ulcer dyspepsia Riezzo et al [154] Erythromycin 7 FD Cucchiara et al [172] Cyproheptadine 44 FD Rodriguez et al [187] Peppermint oil 42 IBS Kline et al [191] Gut-directed hypnotherapy 52 FAP or IBS Vlieger et al [200] 34 ...…”