Anxiety accelerates T-helper 2-tilted immune responses in patients with atopic dermatitis

Hashizume, Hideo; Horibe, Takahiro; Ohshima, Akihiro; Ito, Taisuke; Yanagimoto, Hiroaki; Takigawa, Masaharu

doi:10.1111/j.1365-2133.2005.06449.x

Cited by 78 publications

(56 citation statements)

References 20 publications

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“…Most studies associate high anxiety with reduced HRV and increased HR, which can also be seen in anxiety disorders studies [23]. On the other hand, close similarities between allergy and anxiety were documented [8,19,20]. Similar findings in allergy and anxiety were also found in HPA axis reaction to stress, where both allergy and high trait anxiety subjects exhibited lowered cortisol responses [5,26].…”

Section: Subjective Stress Differencessupporting

confidence: 66%

“…High anxiety, social anxiety and vulnerability to stress were also described in AR [1] and AA [18]. Possible underlying mechanism can be illustrated by correlations of anxiety and Th2 immune response, as well as synthesis of IgE antibody [19]. People with allergy also exhibit higher subjective perception of stress and have higher comorbidity of anxiety disorders [20].…”

mentioning

confidence: 99%

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Increased Heart Rate Variability in Allergic and Highly Trait Anxious Individuals

Rajčáni¹,

Soláriková²,

Brezina³

2017

JPP

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Autonomic dysregulations were repeatedly observed in people with allergic reactions. Contradictory results of sympathetic over-activation on one hand and parasympathetic predominance on the other, were described for both atopic dermatitis and allergic rhinitis. Secondly, psychological traits of high anxiety and depression described in allergic patients are mostly associated with increased sympathetic and decreased vagal modulation. To address inconsistency in prior findings, we aim to study autonomic nervous system changes in allergic and highly anxious people via HR (heart rate) and HRV (heart rate variability) measures during stressful and relax days in day to day life. We further assess differences between allergic diagnoses and impact of acute symptom occurrence on HR and HRV. 61 subjects (26 allergic, 18 healthy high trait anxious and 17 healthy low trait anxious) took part in this study. They were repeatedly measured for HR by a portable electrocardiographic device, and assessed their subjectively experienced stress during everyday life. HRV was analyzed using time-domain, spectral and non-linear analyses. We observed increased HRV and decreased HR in allergic patients and also in healthy highly anxious subjects, when compared to controls. Both atopic dermatitis and allergic rhinitis patients exhibited parasympathetic predominance or sympathetic withdrawal, seen in increased HRV and lowered HR. Described effects of parasympathetic predominance were, however, not present during acute symptoms occurrence.

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Section: Subjective Stress Differencessupporting

confidence: 66%

mentioning

confidence: 99%

Increased Heart Rate Variability in Allergic and Highly Trait Anxious Individuals

Rajčáni¹,

Soláriková²,

Brezina³

2017

JPP

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“…Due to similar psychophysiological changes (24) and reported comorbidity of anxiety and allergy (16,17,18,23) as well as the role of stress in allergic process (15), psychological interventions aimed on better coping and reduction of anxiety could be beneficial to allergic patients (45). Similarly, interventions based on normalization of HRV such as HRV biofeedback might also be employed, which has already been demonstrated in a study with asthma (46).…”

Section: Clinical Relevance Of the Resultsmentioning

confidence: 91%

“…feelings of anxiety (3). Increased trait anxiety was correlated with elevated levels of IgE and increase in Th2 immune response, which play a critical role in development of allergy (16). Other studies (17,18) found that personality traits such as anxiety, depression, a high emotional excitability, as well as higher comorbidity of anxiety disorders were linked to major allergic disorders (atopic dermatitis, allergic rhinitis, allergic asthma).…”

Section: Anxiety and Allergymentioning

confidence: 93%

Allergy and high trait anxiety are related to increases in heart rate variability: results of naturalistic long-term design study

Rajčáni

Soláriková

Brezina

2018

Eur Ann Allergy Clin Immunol

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“…It is a disease caused by combined influences of genetic and environmental factors [4] leading to a Th2-dominated immune response against various allergens [5]. Skin irritants, systemic or local infections, environmental pollutants, stress and hormonal changes may play an aggravating role in the pathophysiology of AE [6, 7]. Especially aeroallergens may induce eczema flares [8, 9].…”

Section: Introductionmentioning

confidence: 99%

Pollen Grains Induce a Rapid and Biphasic Eczematous Immune Response in Atopic Eczema Patients

Eyerich

Huss‐Marp

Darsow

et al. 2007

Int Arch Allergy Immunol

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Introduction: Eczematous reactions to type I allergy-inducing antigens are documented in a subgroup of patients with atopic eczema. Yet, the underlying immunological mechanisms are not well understood. Material and Methods: To delineate the effect of native pollen grains on human skin of healthy and atopic individuals we performed patch tests (atopy patch test with native pollen grains, PPT). Nickel patch tests (NPT) served as an established model of contact dermatitis. Skin site biopsies were taken 6–96 h after allergen application and investigated immunohistochemically. Results: Histology of positive patch tests showed an influx of mononuclear cells (predominantly CD4+, CD25+, CD45RO+). This influx was detected earlier in the PPT reaction than in the immune response to nickel. A biphasic cytokine response could be detected in the PPT: IL-5 dominated in the early, IFN-γ in the late phase. The NPT was continuously dominated by IFN-γ. Dendritic cell subpopulations imitated the earlier kinetics of the mononuclear infiltrate. Discussion: Thus, pollen grains induce eczematous reactions in susceptible individuals. This reaction appears clinically and immunohistochemically similar to the contact hypersensitivity reaction to nickel but follows a faster kinetic and a biphasic course: Th2 and IgE in the early (24 h) and Th1 predominance in the late (96 h) phase.

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Anxiety accelerates T-helper 2-tilted immune responses in patients with atopic dermatitis

Abstract: The patients with AD had higher anxiety levels than normal individuals, and those with a stronger perception of TA than SA showed enhanced serum IgE synthesis and Th2 shifting.

Cited by 78 publications

References 20 publications

Increased Heart Rate Variability in Allergic and Highly Trait Anxious Individuals

Increased Heart Rate Variability in Allergic and Highly Trait Anxious Individuals

Allergy and high trait anxiety are related to increases in heart rate variability: results of naturalistic long-term design study

Pollen Grains Induce a Rapid and Biphasic Eczematous Immune Response in Atopic Eczema Patients

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