Anxiety among adults with a history of childhood adversity: Psychological resilience moderates the indirect effect of emotion dysregulation

Poole, Julia C.; Dobson, Keith S.; Pusch, Dennis

doi:10.1016/j.jad.2017.03.047

Cited by 105 publications

(62 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, this indicates a resilient sample of women, limiting the generalizability of these findings. There is an emerging literature on protective factors that may provide resilience to ACEs, including attachment style, positive childhood experiences, emotion regulation, and coping style (Beutel et al, 2017; Dagan et al, 2017; Gouin et al, 2017; Narayan et al, 2018; Poole et al, 2017), which were not assessed in this study. In addition, there were relatively few women in the sample who had experienced severe adversity (i.e.…”

Section: Discussionmentioning

confidence: 99%

Childhood adversity impact on gut microbiota and inflammatory response to stress during pregnancy

Hantsoo

Jašarević

Criniti

et al. 2019

Brain, Behavior, and Immunity

127

105

View full text Add to dashboard Cite

Background: Adverse childhood experiences (ACEs), such as abuse or chronic stress, program an exaggerated adult inflammatory response to stress. Emerging rodent research suggests that the gut microbiome may be a key mediator in the association between early life stress and dysregulated glucocorticoid-immune response. However, ACE impact on inflammatory response to stress, or on the gut microbiome, have not been studied in human pregnancy, when inflammation increases risk of poor outcomes. The aim of this study was to assess the relationships among ACE, the gut microbiome, and cytokine response to stress in pregnant women. Methods: Physically and psychiatrically healthy adult pregnant women completed the Adverse Childhood Experiences Questionnaire (ACE-Q) and gave a single stool sample between 20 and 26 weeks gestation. Stool DNA was isolated and 16S sequencing was performed. Three 24-hour food recalls were administered to assess dietary nutrient intake. A subset of women completed the Trier Social Stress Test (TSST) at 22–34 weeks gestation; plasma interleukin-6 (IL-6), interleukin-1β (IL-1β), high sensitivity C-reactive protein (hsCRP), tumor necrosis factor α (TNF-α), and cortisol were measured at four timepoints pre and post stressor, and area under the curve (AUC) was calculated. Results: Forty-eight women completed the ACE-Q and provided stool; 19 women completed the TSST. Women reporting 2 or more ACEs (high ACE) had greater differential abundance of gut Prevotella than low ACE participants (q=5.7×10^−13). Abundance of several gut taxa were significantly associated with cortisol, IL-6, TNF-α and CRP AUCs regardless of ACE status. IL-6 response to stress was buffered among high ACE women with high intake of docosahexaenoic acid (DHA) (p=0.03) and eicosapentaenoic acid (EPA) (p=0.05). Discussion: Our findings suggest that multiple childhood adversities are associated with changes in gut microbiota composition during pregnancy, and such changes may contribute to altered inflammatory and glucocorticoid response to stress. While preliminary, this is the first study to demonstrate an association between gut microbiota and acute glucocorticoid-immune response to stress in a clinical sample. Finally, exploratory analyses suggested that high ACE women with high dietary intake of ω-3 polyunsaturated fatty acids (PUFAs) had a dampened inflammatory response to acute stress, suggesting potentially protective effects of ω-3s in this high-risk population. Given the adverse effects of inflammation on pregnancy and the developing fetus, mechanisms by which childhood adversity influence the gut-brain axis and potential protective factors such as diet should be further explored.

show abstract

Section: Discussionmentioning

confidence: 99%

Childhood adversity impact on gut microbiota and inflammatory response to stress during pregnancy

Hantsoo

Jašarević

Criniti

et al. 2019

Brain, Behavior, and Immunity

127

105

View full text Add to dashboard Cite

show abstract

“…CTQ scores below and above the median were used to define lesser and higher occurrence of trauma, respectively. To analyze the childhood trauma subtypes, 2 different measures were used: the first measure consisted of the occurrence or nonoccurrence of each childhood trauma subtype (binary measure), and the second measure was defined according to the severity of the trauma subtype (no [score = 5], mild [6][7][8][9][10], moderate [11][12][13][14][15], or intense [16][17][18][19][20][21][22][23][24][25]). 46 For the BAI and BDI measures, analyses were performed that considered the standard cutoff point of the questionnaires in the Brazilian population.…”

Section: Discussionmentioning

confidence: 99%

“…10 These criteria include specific symptoms that characterize the clinical condition of the patient. [7][8][9]11 Stressor events experienced in childhood are risk factors for the development of emotional disorders in adulthood. [7][8][9]11 Stressor events experienced in childhood are risk factors for the development of emotional disorders in adulthood.…”

Section: Introductionmentioning

confidence: 99%

“…10 However, several studies have assessed anxiety and depression levels with validated and standardized instruments for clinical and nonclinical populations. 11,12 Few investigations have explored the occurrence of traumatic events in childhood in patients with cancer, [13][14][15][16][17][18][19] and the majority have been conducted with patients with breast cancer. 11,12 Few investigations have explored the occurrence of traumatic events in childhood in patients with cancer, [13][14][15][16][17][18][19] and the majority have been conducted with patients with breast cancer.…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9]11 Stressor events experienced in childhood are risk factors for the development of emotional disorders in adulthood. 11,12 Few investigations have explored the occurrence of traumatic events in childhood in patients with cancer, [13][14][15][16][17][18][19] and the majority have been conducted with patients with breast cancer. [13][14][15][16][17][18] Studies have shown a significant association between childhood trauma and cancer-related psychological symptoms, such as self-blame, bodily shame, and stress in Cancer September 15, 2018 women diagnosed with breast cancer.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Childhood trauma is predictive for clinical staging, alcohol consumption, and emotional symptoms in patients with head and neck cancer

Sarafim-Silva

Duarte

Sundefeld

et al. 2018

Cancer

View full text Add to dashboard Cite

show abstract

Regulating Emotionality to Manage Adversity: A Systematic Review of the Relation Between Emotion Regulation and Psychological Resilience

Polizzi

Lynn

2021

Cogn Ther Res

View full text Add to dashboard Cite

Anxiety among adults with a history of childhood adversity: Psychological resilience moderates the indirect effect of emotion dysregulation

Cited by 105 publications

References 62 publications

Childhood adversity impact on gut microbiota and inflammatory response to stress during pregnancy

Childhood adversity impact on gut microbiota and inflammatory response to stress during pregnancy

Childhood trauma is predictive for clinical staging, alcohol consumption, and emotional symptoms in patients with head and neck cancer

Regulating Emotionality to Manage Adversity: A Systematic Review of the Relation Between Emotion Regulation and Psychological Resilience

Contact Info

Product

Resources

About