COVID-19 pandemic is a global health crisis. It has affected the working lives and psychological health of orthopedic surgeons in Pakistan. However, there is a lack of research on this topic, therefore the current study has examined the effects of COVID-19 Pandemic on the working lives and psychological health of orthopedic surgeons in Pakistan. Using a cross-sectional survey research design, data were collected from 364 orthopedic surgeons in Pakistan. Missing data analysis were performed with Little's Test for Missing Data. Descriptive Statistics were used to report results on effects of COVID-19 pandemic. Chisquare test was used to determine association between COVID-19 pandemic and psychological health. Findings revealed that majority of orthopedic surgeons were not directly involved in the care of COVID-19 patients, however, those who were involved had experienced a high level of stress, fear, and anxiety. It was because the orthopedic surgeons had no proper personal protection equipment, and government response toward COVID-19 was not satisfactory. Moreover, work-life balance of orthopedic surgeons was also disturbed. The COVID-19 pandemic is major health crisis. It has severely affected the working lives and psychological health of the orthopedic surgeons in Pakistan. The Orthopedic surgeons can cope with the psychological effects of COVID-19 through developing resilience and self-control. Moreover, they can avail social support from family, and engage in two-way communication and teambuilding activities in hospitals.