Anxiety and clinical outcomes of patients with acute coronary syndrome: a meta-analysis

Li, Jie; Feng, Jia‐Xun; Song, Junxian; Gao, Xiangyang; Jiang, Deguo; Chen, Guangdong; Chen, Suling; Lin, Xiaodong; Zhuo, Chuanjun

doi:10.1136/bmjopen-2019-034135

Cited by 29 publications

(24 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…14,16,23 Some studies found that the association between anxiety and long-term prognosis was insignificant after adjusted for depression. 23,34 And other studies shown the different results. 14,16 So in order to explore the potential influence of depression between anxiety and prognosis in patients with MI.…”

Section: Discussionmentioning

confidence: 89%

“…Previous studies have confirmed that both depression and anxiety were associated with poor prognosis in patients with MI 14,16,23 . Some studies found that the association between anxiety and long‐term prognosis was insignificant after adjusted for depression 23,34 . And other studies shown the different results 14,16 .…”

Section: Discussionmentioning

confidence: 90%

“…In two previous meta-analyses, MI patients with anxiety had a poorer prognosis than those without anxiety. 34,35 In one meta analysis, patients with MI and unstable angina were included, the results were assessed using bivariate analysis, and there was a significant publication bias in the combined outcomes. 35 The other metaanalysis evaluated the effect of anxiety in patients with ACS, and included patients with depression or other factors.…”

Section: Discussionmentioning

confidence: 99%

“…35 The other metaanalysis evaluated the effect of anxiety in patients with ACS, and included patients with depression or other factors. 34 In addition, both the meta-analyses focused on only long-term prognosis, and did not analyze the association between anxiety and the short-term prognosis of patients with MI. Therefore, we performed an updated metaanalysis to compare the clinical outcomes in MI patients with and without anxiety.…”

Section: Discussionmentioning

confidence: 99%

“…In one meta analysis, patients with MI and unstable angina were included, the results were assessed using bivariate analysis, and there was a significant publication bias in the combined outcomes 35 . The other meta‐analysis evaluated the effect of anxiety in patients with ACS, and included patients with depression or other factors 34 . In addition, both the meta‐analyses focused on only long‐term prognosis, and did not analyze the association between anxiety and the short‐term prognosis of patients with MI.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Anxiety and prognosis of patients with myocardial infarction: A meta‐analysis

Wen

Yang

Shen

et al. 2021

Clinical Cardiology

View full text Add to dashboard Cite

Although anxiety is highly prevalent after myocardial infarction (MI), but the association between anxiety and MI is not well established. This study aimed to provide an updated and comprehensive evaluation of the association between anxiety and short‐term and long‐term prognoses in patients with MI. Anxiety is associated with poor short‐term and long‐term prognoses in patients with MI. We performed a systematic search in the PubMed and Cochrane databases (January 2000–October 2020). The study endpoints were complications, all‐cause mortality, cardiac mortality, and/or major adverse cardiac events (MACEs). Pooled data were synthesized using Stata SE12.0 and expressed as risk ratios (RRs) and 95% confidence intervals (CIs). We included 9373 patients with MI from 16 published studies. Pooled analyses indicated a correlation between high anxiety and poor clinical outcomes (RR: 1.19, 95% CI: 1.13–1.26, p < .001), poor short‐term complications (RR: 1.23, 95% CI: 1.09–1.38, p = .001), and poor long‐term prognosis (RR: 1.27, 95% CI: 1.13–1.44, p < .001). Anxiety was also specifically associated with long‐term mortality (RR: 1.16, 95% CI: 1.01–1.33, p = .033) and long‐term MACEs (RR: 1.54, 95% CI: 1.26–1.90, p < .001). This study provided strong evidence that increased anxiety was associated with poor prognosis in patients with MI. Further analysis revealed that MI patients with anxiety had a 23% increased risk of short‐term complications and a 27% increased risk of adverse long‐term prognosis compared to those without anxiety.

show abstract

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Anxiety and prognosis of patients with myocardial infarction: A meta‐analysis

Wen

Yang

Shen

et al. 2021

Clinical Cardiology

View full text Add to dashboard Cite

show abstract

Anxiety is associated with higher recurrence of atrial fibrillation after catheter ablation: A meta‐analysis

Yang

et al. 2022

Clinical Cardiology

View full text Add to dashboard Cite

Previous studies that evaluated the influence of anxiety on recurrence of atrial fibrillation (AF) after catheter ablation showed inconsistent results. We performed a meta‐analysis of cohort study to systematically evaluate the association between anxiety and AF recurrence after catheter ablation. Electronic databases of PubMed, Embase, and Web of Science were searched for relevant cohort studies from inception to January 20, 2021. We applied the random‐effect model to combine the results to incorporate the potential influence of heterogeneity among studies. Five cohort studies were eligible for the meta‐analysis, which included 549 patients with AF that received catheter ablation. No significant heterogeneity was observed among the included studies (I2 = 7%, P for Cochrane's Q test = 0.37). During a mean follow‐up of 9.7 months, 216 (39.3%) cases of recurrent AF occurred. Results of the meta‐analysis showed that anxiety was independently associated with an increased risk of AF recurrence after catheter ablation (adjusted relative risk: 2.36, 95% confidence interval: 1.71–3.26; p < .001). Subgroup analyses did not show that differences in study characteristics including study design, ethnicity of the patients, sample size, AF type, anxiety evaluation method, follow‐up duration, or adjustment of LAD may significantly affect the association between anxiety and AF recurrence (p for subgroup difference all > .10). Anxiety may be an independent risk factor for AF recurrence after catheter ablation. Whether alleviating anxiety mood could reduce the risk of AF recurrence after catheter ablation should also be investigated.

show abstract

Impact of mental disorders on clinical outcomes of physical diseases: an umbrella review assessing population attributable fraction and generalized impact fraction

et al. 2023

View full text Add to dashboard Cite

Empirical evidence indicates a significant bidirectional association between mental disorders and physical diseases, but the prospective impact of mental disorders on clinical outcomes of physical diseases has not been comprehensively outlined. In this PRISMA‐ and COSMOS‐E‐compliant umbrella review, we searched PubMed, PsycINFO, Embase, and Joanna Briggs Institute Database of Systematic Reviews and Implementation Reports, up to March 15, 2022, to identify systematic reviews with meta‐analysis that examined the prospective association between any mental disorder and clinical outcomes of physical diseases. Primary outcomes were disease‐specific mortality and all‐cause mortality. Secondary outcomes were disease‐specific incidence, functioning and/or disability, symptom severity, quality of life, recurrence or progression, major cardiac events, and treatment‐related outcomes. Additional inclusion criteria were further applied to primary studies. Random effect models were employed, along with I2 statistic, 95% prediction intervals, small‐study effects test, excess significance bias test, and risk of bias (ROBIS) assessment. Associations were classified into five credibility classes of evidence (I to IV and non‐significant) according to established criteria, complemented by sensitivity and subgroup analyses to examine the robustness of the main analysis. Statistical analysis was performed using a new package for conducting umbrella reviews (https://metaumbrella.org/). Population attributable fraction (PAF) and generalized impact fraction (GIF) were then calculated for class I‐III associations. Forty‐seven systematic reviews with meta‐analysis, encompassing 251 non‐overlapping primary studies and reporting 74 associations, were included (68% were at low risk of bias at the ROBIS assessment). Altogether, 43 primary outcomes (disease‐specific mortality: n=17; all‐cause mortality: n=26) and 31 secondary outcomes were investigated. Although 72% of associations were statistically significant (p<0.05), only two showed convincing (class I) evidence: that between depressive disorders and all‐cause mortality in patients with heart failure (hazard ratio, HR=1.44, 95% CI: 1.26‐1.65), and that between schizophrenia and cardiovascular mortality in patients with cardiovascular diseases (risk ratio, RR=1.54, 95% CI: 1.36‐1.75). Six associations showed highly suggestive (class II) evidence: those between depressive disorders and all‐cause mortality in patients with diabetes mellitus (HR=2.84, 95% CI: 2.00‐4.03) and with kidney failure (HR=1.41, 95% CI: 1.31‐1.51); that between depressive disorders and major cardiac events in patients with myocardial infarction (odds ratio, OR=1.52, 95% CI: 1.36‐1.70); that between depressive disorders and dementia in patients with diabetes mellitus (HR=2.11, 95% CI: 1.77‐2.52); that between alcohol use disorder and decompensated liver cirrhosis in patients with hepatitis C (RR=3.15, 95% CI: 2.87‐3.46); and that between schizophrenia and cancer mortality in patients with cancer (standardized mean ratio...

show abstract

Anxiety and clinical outcomes of patients with acute coronary syndrome: a meta-analysis

Cited by 29 publications

References 41 publications

Anxiety and prognosis of patients with myocardial infarction: A meta‐analysis

Anxiety and prognosis of patients with myocardial infarction: A meta‐analysis

Anxiety is associated with higher recurrence of atrial fibrillation after catheter ablation: A meta‐analysis

Impact of mental disorders on clinical outcomes of physical diseases: an umbrella review assessing population attributable fraction and generalized impact fraction

Contact Info

Product

Resources

About