Anxiety and cognitive effects of quercetin liposomes in rats

Priprem, Aroonsri; Watanatorn, Jintanaporn; Sutthiparinyanont, Saengrawee; Phachonpai, Wathita; Muchimapura, Supaporn

doi:10.1016/j.nano.2007.12.001

Cited by 193 publications

(102 citation statements)

References 37 publications

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“…With respect to their therapeutic importance as anxiolytic and sedative-like compounds, it has been demonstrated that flavonoids such as quercetin, rutin and kaempferol elicit Central Nervous System activity involving the inhibitory GABAergic system. 18,26,27 As described, rutin was the other abundant flavonoid detected in the active extract; it is known that plants increase glycosylated aglicone production as a mechanism to avoid damage. 28 This property of plants is also an advantage in folk medicine, since they can be used as tranquilizers, among other therapeutic properties.…”

Section: Resultsmentioning

confidence: 92%

Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation

Aguirre-Hernández

González-Trujano

Terrazas

et al. 2016

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Section: Resultsmentioning

confidence: 92%

Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation

Aguirre-Hernández

González-Trujano

Terrazas

et al. 2016

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“…Both conventional and quercetin liposomes showed anxiolytic and cognitiveenhancing effects. A lower dose and a faster rate were observed with intranasal quercetin liposomes when compared with oral quercetin, conventional and liposomal and the intranasal quercetin liposomes are effective in the delivery of quercetin to the central nervous system [141] .…”

Section: Recent Advances Of Bioenhancersmentioning

confidence: 90%

Bioavailability enhancers of herbal origin: An overview

Kesarwani

Gupta

2013

Asian Pacific Journal of Tropical Biomedicine

397

197

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“…3 It delivers a low intrinsic toxicity and has a surprisingly wide range of beneficial actions, such as antiplatelet, antiradical, anti-inflammatory, antimutagenic, anticarcinogenic, anti-angiogenic, antibacterial, antitumor, antiviral, antianxiety, and cognitive-enhancing effects on the central nervous system. [4][5][6] However, despite the wide spectrum of pharmacological properties, the use of QT in the pharmaceutical field is obstructed due to its hydrophobic nature, physiological medium instability, 7 and limited consumption in the brain. 5,8 These properties of QT result in low oral bioavailability and restrict its permeability through the blood-brain barrier (BBB).…”

Section: Introductionmentioning

confidence: 99%

Poly(n-butylcyanoacrylate) nanoparticles for oral delivery of quercetin: preparation, characterization, and pharmacokinetics and biodistribution studies in Wistar rats

Bagad¹,

Khan²

2015

IJN

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Background Quercetin (QT) is a potential bioflavonol and antioxidant with poor bioavailability and very low distribution in the brain. A new oral delivery system comprising of poly(n-butylcyanoacrylate) nanoparticles (PBCA NPs) was introduced to improve the oral bioavailability of QT and to increase its distribution in the brain. Physicochemical characteristics, in vitro release, stability in simulated gastric fluid and intestinal fluids, and pharmacokinetics and biodistribution studies of QT-PBCA NPs coated with polysorbate-80 (P-80) were investigated. Objective This study aimed to investigate the physicochemical characteristics, in vitro release, stability in simulated gastric fluid and intestinal fluids, and pharmacokinetics and biodistribution studies of QT-PBCA NPs coated with polysorbate-80 (P-80). Results The results showed that QT-PBCA NPs and QT-PBCA NPs coated with P-80 (QT-PBCA+P-80) had mean particle sizes of 161.1±0.44 nm and 166.6±0.33 nm respectively, and appeared spherical in shape under transmission electron microscopy. The mean entrapment efficiency was 79.86%±0.45% for QT-PBCA NPs and 74.58%±1.44% for QT-PBCA+P-80. The in vitro release of QT-PBCA NPs and QT-PBCA+P-80 showed an initial burst release followed by a sustained release when compared to free QT. The relative bioavailability of QT-PBCA NPs and QT-PBCA+P-80 enhanced QT bioavailability by 2.38- and 4.93-fold respectively, when compared to free QT. The biodistribution study in rats showed that a higher concentration of QT was detected in the brain after the NPs were coated with P-80. Conclusion This study indicates that PBCA NPs coated with P-80 can be potential drug carriers for poorly water-soluble drugs. These NPs were observed to improve the drugs’ oral bioavailability and enhance their transport to the brain.

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Anxiety and cognitive effects of quercetin liposomes in rats

Cited by 193 publications

References 37 publications

Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation

Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation

Bioavailability enhancers of herbal origin: An overview

Poly(n-butylcyanoacrylate) nanoparticles for oral delivery of quercetin: preparation, characterization, and pharmacokinetics and biodistribution studies in Wistar rats

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