Anxiety and Depression Comorbidities in Moroccan Patients With Breast Cancer

Aquil, Amina; Khoudri, Noureddine El; Mouallif, Mustapha; Daghi, Mohamed; Guerroumi, Maroua; Saad, Elmadani; Benider, Abdellatif; Jayakumar, Arumugam R.; Elgot, Abdeljalil

doi:10.3389/fpsyt.2020.584907

Cited by 10 publications

(5 citation statements)

References 32 publications

(17 reference statements)

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“…SCZ was the risk factor for overall breast cancer, ER+ breast cancer and ER-breast cancer. Interestingly, many observational studies have indicated that breast cancer is a risk factor for psychiatric disorders (24)(25)(26), but our MR analysis showed a reverse finding.…”

Section: Discussioncontrasting

confidence: 65%

The genetic interplay between psychiatric disorders and breast cancer risk: A bidirectional Mendelian randomization study

Zhang¹,

Fang

Ji³

et al. 2022

Preprint

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Background Evidence of the association between psychiatric disorders, and breast cancer have been inconsistent, and their interpretation often encounters confounding factors. In this study, we used bidirectional Mendelian randomization (MR) analysis to explore the genetic relationships between them. Methods We performed an MR analysis using publicly available genome-wide association studies of European ancestry to simultaneously examine the relationship between psychiatric disorders, and breast cancer risk. The inverse-variance weighted method for the assessment of the risk psychiatric disorders bring to breast cancer. Weighted media, and MR-Egger regression were used as sensitivity analyses. Results The MR analysis revealed that major depressive disorder (MDD) may increase the risk of overall breast cancer (odds ratio [OR] = 1.095, 95% confidence interval [CI] = 1.019-1.277, P = 0.014), but not the subtype of breast cancer. Schizophrenia (SCZ) was a risk factor for overall breast cancer (OR = 1.031, 95%CI = 1.012-1.050, P = 0.002), ER+ breast cancer (OR = 1.034, 95%CI = 1.012-1.057, P = 0.002) and ER- breast cancer (OR = 1.050, 95%CI = 1.017-1.084, P = 0.003). However, patients with breast cancer are less likely to have the risk of MDD and SCZ. Conclusion: Our results found that MDD may be a risk factor for overall breast cancer but is not related to its subtypes. SCZ may increase the risk of breast cancer and its subtypes.

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Section: Discussioncontrasting

confidence: 65%

The genetic interplay between psychiatric disorders and breast cancer risk: A bidirectional Mendelian randomization study

Zhang¹,

Fang

Ji³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Among patients with cancer with different types of insurance, the DA level of self-funded patients with cancer was the highest, suggesting that better medical reimbursement can relieve some of the burden of medical costs on patients, thereby allowing them to focus on their illnesses 35. A study abroad also showed that patients with cancer with health insurance had lower levels of anxiety and depression 36. Therefore, the DA of patients with cancer without insurance should be better reduced.…”

Section: Discussionmentioning

confidence: 99%

“…35 A study abroad also showed that patients with cancer with health insurance had lower levels of anxiety and depression. 36 Therefore, the DA of patients with cancer without insurance should be better reduced.…”

Section: Open Accessmentioning

confidence: 99%

Factors influencing death anxiety among Chinese patients with cancer: a cross-sectional study

Gong

Yang²,

Cheng³

et al. 2022

BMJ Open

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ObjectiveThe purpose of this study was to investigate death anxiety status among Chinese patients with cancer and identify factors that affect death anxiety.DesignCross-sectional study.SettingChangsha, Hunan Province, China.ParticipantsA total of 286 inpatients diagnosed with cancer were randomly recruited from a tertiary cancer centre and completed the questionnaires between January and June 2021.Primary and secondary outcome measuresThe primary outcome was the status of death anxiety. The secondary outcomes were the factors that affect death anxiety among Chinese patients with cancer.MethodsA total of 286 Chinese patients with cancer were recruited from a tertiary cancer hospital to complete the demographic and clinical characteristics questionnaire, Templer’s Death Anxiety Scale, Acceptance and Action Questionnaire-second edition, and Meaning in Life Questionnaire from January to June 2021. Data were analysed using t-test, analysis of variance, Kruskal-Wallis H test, Pearson correlation analysis and multiple linear regression analysis.ResultsOn average, patients with cancer scored 7.72±4.17 for death anxiety, 25.71±9.69 for experiential avoidance and 45.19±8.22 for meaning in life. Ultimately, the statistically significant factors influencing death anxiety were education levels, insurance, pain scores, experiential avoidance and meaning in life. These factors explained 40.6% of the difference in death anxiety.ConclusionsPatients with cancer in China experienced a high level of death anxiety. This study showed that experiential avoidance and meaning in life were important factors that affected death anxiety in patients with cancer. Further studies should be conducted to explore effective interventions to prevent experiential avoidance and increase meaning in life for patients with cancer. Attention should be paid to patients without insurance but with lower education levels and higher pain scores to ultimately relieve death anxiety and improve their quality of life.

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“…Psychological problems in patients with breast cancer should receive more attention [ 32 ]. Our results suggest that anxiety and depression were common in the NAC group of our patient cohort.…”

Section: Discussionmentioning

confidence: 99%

Neoadjuvant Chemotherapy Is Effective in Those Infected With SARS-CoV-2: The Real-World Experience of a Large Chinese Breast Cancer Center

Ma,

Wang

et al. 2024

J Breast Cancer

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Purpose During the major shift in China's policies on coronavirus disease 2019 (COVID-19), many residents will be infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) over a short period, including a few patients with breast cancer undergoing neoadjuvant chemotherapy (NAC). Moreover, it is unknown whether this comorbidity affects the efficacy of NAC for breast cancer and the patient's psychological state and quality of life (QOL). This study aims to answer these questions. Methods The clinical data of 2,793 patients with breast cancer who received NAC at The Affiliated Hospital of Qingdao University were retrospectively collected. The infected and non-infected groups were divided according to whether they were infected with COVID-19 during NAC. Propensity score matching was used to reduce patient selection bias. The effectiveness, psychological well-being, and QOL of the two groups were compared. Results No discernible differences were observed in the pathological complete response rates ( p = 0.307) and major histological responses rate ( p = 0.398) between the infected and non-infected groups. Following the full course of NAC, the Functional Assessment of Cancer Treatment General ( p < 0.001) and Functional Assessment of Cancer Therapy for Breast Cancer ( p < 0.001) were lower in the infected group than the non-infected group, the Hospital Anxiety and Depression Scale (HADS) anxiety scale ( p < 0.001) and HADS depression scale ( p < 0.001) were considerably higher in the infected group than the non-infected group. Conclusion With timely treatment and effective medical management, SARS-CoV-2 does not appear to affect the efficacy of NAC; however, it can significantly affect the QOL of patients and increase their psychological distress. Therefore, in addition to a timely assessment of the efficacy of NAC, it is necessary to dynamically understand the patient's psychological state and QOL.

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Anxiety and Depression Comorbidities in Moroccan Patients With Breast Cancer

Cited by 10 publications

References 32 publications

The genetic interplay between psychiatric disorders and breast cancer risk: A bidirectional Mendelian randomization study

The genetic interplay between psychiatric disorders and breast cancer risk: A bidirectional Mendelian randomization study

Factors influencing death anxiety among Chinese patients with cancer: a cross-sectional study

Neoadjuvant Chemotherapy Is Effective in Those Infected With SARS-CoV-2: The Real-World Experience of a Large Chinese Breast Cancer Center

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