Anxiety and depression in Slovak patients with rheumatoid arthritis

Soósová, Mária Sováriová; Macejová, Želmíra; Zamboriová, Mária; Dimunová, Lucia

doi:10.1080/09638237.2016.1244719

Cited by 24 publications

(28 citation statements)

References 32 publications

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“…Depression also has a high prevalence in patients with rheumatoid arthritis (RA). Studies showed a 74% increased risk of depression compared to controls with a prevalence as high as 73.2%, and a meta-analysis found that 16.8% of RA patients suffer from it (70–72). Up to 80% of patients who are diagnosed with RA experience clinically relevant fatigue (73).…”

Section: Immune Activation Is Associated With Depression and Fatiguementioning

confidence: 99%

The Role of Inflammation in Depression and Fatigue

2019

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Depression and fatigue are conditions responsible for heavy global societal burden, especially in patients already suffering from chronic diseases. These symptoms have been identified by those affected as some of the most disabling symptoms which affect the quality of life and productivity of the individual. While many factors play a role in the development of depression and fatigue, both have been associated with increased inflammatory activation of the immune system affecting both the periphery and the central nervous system (CNS). This is further supported by the well-described association between diseases that involve immune activation and these symptoms in autoimmune disorders, such as multiple sclerosis and immune system activation in response to infections, like sepsis. Treatments for depression also support this immunopsychiatric link. Antidepressants have been shown to decrease inflammation, while higher levels of baseline inflammation predict lower treatment efficacy for most treatments. Those patients with higher initial immune activation may on the other hand be more responsive to treatments targeting immune pathways, which have been found to be effective in treating depression and fatigue in some cases. These results show strong support for the hypothesis that depression and fatigue are associated with an increased activation of the immune system which may serve as a valid target for treatment. Further studies should focus on the pathways involved in these symptoms and the development of treatments that target those pathways will help us to better understand these conditions and devise more targeted treatments.

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Section: Immune Activation Is Associated With Depression and Fatiguementioning

confidence: 99%

The Role of Inflammation in Depression and Fatigue

2019

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“…9 It has been shown that RA patients are at higher risk of presenting anxiety and depression, which worsens the state of their disease and also the response to conventional treatment. 10 The importance of the correct evaluation and identification of these emotional disorders has been the subject of lesser research in the rheumatology field and many times they are underdiagnosed, causing the patient not to have optimal results in their clinical improvement or remission. 1,6 The purpose of this review is to evaluate and identify psychiatric comorbidities associated with RA that lead to deterioration in the quality of life and, in turn, identify other manifestations that are not normally evaluated in the rheumatology consult such as sarcopenia, frailty, and cachexia, in order to optimize the clinical management.…”

Section: Introductionmentioning

confidence: 99%

Beyond Rheumatoid Arthritis Evaluation: What are We Missing?

Espinoza¹,

Maldonado²,

Narvaez³

et al. 2021

OARRR

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Rheumatoid Arthritis (RA) is a chronic inflammatory autoimmune systemic disease that preferentially affects small and large joints with a progressive course and can become deforming and disabling. In recent years, much progress has been made in the evaluation of inflammation and disease activity, however, there are other factors that have a high impact on the quality of life of these patients, such as depression, anxiety, fatigue, sleep disorders, suicidal behavior, fibromyalgia, sexual activity, sarcopenia, frailty, cachexia and obesity that are not always evaluated by rheumatologists. This review shows that the evaluation and timely detection of these aspects in patients with RA could interfere with the prognosis and improve their quality of life.

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“…Comorbid depression increases social impairment (84, 85) and disability (86) in patients with RA. Functional capacity seems to be more compromised in women than in men with concomitant RA and MDD (63).…”

Section: Autonomic Nervous System and Affective Disorders In Rheumatomentioning

confidence: 99%

The Link Between Autonomic Nervous System and Rheumatoid Arthritis: From Bench to Bedside

et al. 2020

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Neuronal stimulation is an emerging field of research focused on the management and treatment of various diseases through the reestablishment of physiological homeostasis. Electrical vagus nerve stimulation has recently been proposed as a revolutionary therapeutic option for rheumatoid arthritis (RA) in combination with or even as a replacement for conventional and biological drugs. In the past few years, disruption of the autonomic system has been linked to RA onset and activity. Novel research on the link between the autonomic nervous system and the immune system (immune-autonomics) has paved the way for the development of innovative RA management strategies. Clinical evidence supports this approach. Cardiovascular involvement, in terms of reduced baroreflex sensitivity and heart rate variability-derived indices, and mood disorders, common comorbidities in patients with RA, have been linked to autonomic nervous system dysfunction, which in turn is influenced by increased levels of circulating pro-inflammatory cytokines. This narrative review provides an overview of the autonomic nervous system and RA connection, discussing most of the common cardiac and mental health-related RA comorbidities and their potential relationships to systemic and joint inflammation.

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Anxiety and depression in Slovak patients with rheumatoid arthritis

Abstract: These findings support the notions that psychological negative affect can influence subjective perception of arthritis pain and disability. The regular screening of anxiety and depression and the psychological approaches can be useful for managing arthritis patients.

Cited by 24 publications

References 32 publications

The Role of Inflammation in Depression and Fatigue

The Role of Inflammation in Depression and Fatigue

Beyond Rheumatoid Arthritis Evaluation: What are We Missing?

The Link Between Autonomic Nervous System and Rheumatoid Arthritis: From Bench to Bedside

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