2001
DOI: 10.1067/moe.2001.115465
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Anxiety and pain suppress the natural killer cell activity in oral surgery outpatients

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Cited by 27 publications
(29 citation statements)
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“…An increasing number of studies focus on the quality of life (QOL) of SCCHN patients [3,15,17,18,19,24,25,26,27,28,29,30,31,32,33,34,35,38,39,40,41,42]. QOL is multifactorial and subjective, and improvement in cancer-related symptoms can be achieved through primary assessment and intervention for problems as they arise [15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35].…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…An increasing number of studies focus on the quality of life (QOL) of SCCHN patients [3,15,17,18,19,24,25,26,27,28,29,30,31,32,33,34,35,38,39,40,41,42]. QOL is multifactorial and subjective, and improvement in cancer-related symptoms can be achieved through primary assessment and intervention for problems as they arise [15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35].…”
Section: Methodsmentioning
confidence: 99%
“…The last of these remains one of the more significant challenges to effective treatment in the long term, as the overall survival rates for SCCHN have not radically improved since the 1970s [3,15,16,22,23,24,25,26,27,28]. In addition, pain remains a common symptom in SCCHN patients and suffering has been underevaluated in patients with primary stage SCCHN [15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37].…”
Section: Introductionmentioning
confidence: 99%
“…Several meta-analytic studies and reviews have demonstrated consistent correlations between depressed mood, emotional distress and decrements in cellular immune parameters such as the T-cell response to mitogen stimulation and the cytotoxic activity of natural killer (NK) cells (Irwin, 1999(Irwin, , 2002Irwin and Miller, 2007;Reiche et al, 2004;Segerstrom and Miller, 2004). Anxious mood has also been associated with impairments in the cellular immune response (Koga et al, 2001;Thornton et al, 2007), and interventions that decrease anxiety have shown increases in T-cell response to mitogens in women with breast cancer (Andersen et al, 2004) and longterm increases in CD3 + CD8 + lymphocytes in men with HIV (Antoni et al, 2000a).…”
Section: Introductionmentioning
confidence: 99%
“…Animal studies suggest that NK cells are important for cancer control, especially with respect to dissemination and growth of metastases (Wu and Lanier, 2003). Surgical and psychological stress have been reported to suppress NK activity in animals and humans (Andersen et al, 1998;Koga et al, 2001), and this suppression was shown to compromise animal resistance to tumor progression (Ben-Eliyahu et al, 1999a;Shakhar and Ben-Eliyahu, 1998). Importantly, several clinical studies have reported that levels of NK activity at the time of surgery predict long-term survival rates (Taketomi et al, 1998;Takeuchi et al, 2001;Tsutsui et al, 1996).…”
Section: Introductionmentioning
confidence: 99%