2020
DOI: 10.1523/jneurosci.0704-20.2020
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Anxiety and the Neurobiology of Temporally Uncertain Threat Anticipation

Abstract: When extreme, anxiety-a state of distress and arousal prototypically evoked by uncertain danger-can be debilitating. Uncertain anticipation is a shared feature of situations that elicit signs and symptoms of anxiety across psychiatric disorders, species, and assays. Despite the profound significance of anxiety for human health and wellbeing, the neurobiology of uncertain-threat anticipation remains unsettled. Leveraging a paradigm adapted from animal research and optimized for fMRI signal decomposition, we exa… Show more

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Cited by 98 publications
(184 citation statements)
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“…All procedures were approved by the University of Maryland Institutional Review Board. The sample overlaps that featured in work by our group focused on social anxiety and momentary mood (Hur et al, 2020a) and the basic neurobiology of threat processing (Hur et al, 2020b).…”
Section: Methodsmentioning
confidence: 99%
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“…All procedures were approved by the University of Maryland Institutional Review Board. The sample overlaps that featured in work by our group focused on social anxiety and momentary mood (Hur et al, 2020a) and the basic neurobiology of threat processing (Hur et al, 2020b).…”
Section: Methodsmentioning
confidence: 99%
“…Prior to scanning, subjects practiced abbreviated versions of the tasks until staff confirmed their understanding. A detailed description of the peripheral apparatus is available (Hur et al, 2020b). During imaging, foam inserts were used to mitigate potential motion artifacts.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…In order to elucidate the neural circuitry underlying heightened reactivity to unpredictable threat, studies have begun to employ variants of the NPU task during functional magnetic resonance imaging (fMRI). To date, studies have identified a specific frontolimbic circuit that may become engaged during the processing of aversive stimuli ( Bach and Dolan, 2012 ; Grupe and Nitschke, 2013 ; Fox and Shackman, 2019 ; Hur et al. , 2020 ).…”
Section: Introductionmentioning
confidence: 99%
“…Scan lengths longer than 10 min are important as studies have highlighted the negative effects of short scan times on the stability of brain function estimates (Birn et al, 2013; Elliott et al, 2020). There is presently some debate as to whether the ExtA acts mostly as a unified structure, or whether its components represent separate systems underlying different processes, in particular with regard to fear versus anxiety processing or in the tracking of threat imminence (Fox & Shackman, 2019; Goode et al, 2019, 2020; Hur et al, 2020; Tillman et al, 2018; Walker, Miles, & Davis, 2009). Therefore, we utilised this sample to examine the degree of overlap between the ICNs of the CeA and BST; giving an indirect indication as to the similarity of their functions (Gorka et al, 2018; Oler et al, 2012; Tillman et al, 2018; Torrisi et al, 2015, 2019; Weis et al, 2019).…”
Section: Introductionmentioning
confidence: 99%