Anxiety, anxiety disorders, tobacco use, and nicotine: A critical review of interrelationships.

Morissette, Sandra B.; Tull, Matthew T.; Gulliver, Suzy B.; Kamholz, Barbara W.; Zimering, Rose T.

doi:10.1037/0033-2909.133.2.245

Cited by 335 publications

(265 citation statements)

References 330 publications

(476 reference statements)

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“…These data add to the growing theoretical and empirical literature suggesting that smokers with anxiety disorders may benefit from specialized treatment approaches that target these anxiety factors for the purpose of more effectively preventing relapse (Morissette et al, 2007;Zvolensky & Bernstein, 2005). Indeed, from a clinical perspective, the combination of a potentially increased reliance on smoking as a method of coping with the experience of negative mood and diagnosis-specific symptoms accompanied by a particularly pronounced experience of symptoms during quit attempts may help explain why these individuals are a difficult-to-treat sub-population of smokers.…”

Section: Discussionmentioning

confidence: 71%

“…Recent studies have found important linkages between smoking and certain anxiety disorders (Feldner, Babson, & Zvolensky, 2007a;Morissette, Tull, Gulliver, Kamholz, & Zimering, 2007;Patton, Carlin, Coffey, Wolfe, Hibbert, & Bowes, 1998; Zvolensky, Feldner, LeenFeldner, & McLeish, 2005 (Beckham et al, 1995;Breslau et al, 2003;Buckley et al, 2004;Feldner et al, 2007a). Recent controlled work supports the contention that PTSD is associated with earlier relapse compared to persons with no psychopathology (Zvolensky, Gibson et al, in press).…”

Section: Nih Public Accessmentioning

confidence: 99%

“…Recent studies have found important linkages between smoking and certain anxiety disorders (Feldner, Babson, & Zvolensky, 2007a;Morissette, Tull, Gulliver, Kamholz, & Zimering, 2007;Patton, Carlin, Coffey, Wolfe, Hibbert, & Bowes, 1998;Zvolensky, Feldner, LeenFeldner, & McLeish, 2005). Some of the most robust, clinically-significant relations documented between smoking and anxiety conditions have been evident for panic psychopathology (panic attacks [PA], panic disorder [PD], and agoraphobia) and posttraumatic stress disorder (PTSD).…”

mentioning

confidence: 99%

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Evaluation of smoking characteristics among community-recruited daily smokers with and without posttraumatic stress disorder and panic psychopathology

Marshall¹,

Zvolensky²,

Vujanovic³

et al. 2008

Journal of Anxiety Disorders

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The present investigation compared 123 community-recruited daily smokers with posttraumatic stress disorder (PTSD), panic disorder (PD), nonclinical panic attacks (PA), or no current Axis I psychopathology (controls; C) in terms of nicotine dependence, smoking rate, quit history, severity of symptoms during past quit attempts, and motivation for and expectancies about smoking. No differences were observed between groups in regard to smoking rate or nicotine dependence. The PTSD group reported making more lifetime quit attempts than the other groups, and the PTSD and PD groups perceived more severe symptoms during past quit attempts. The PD and PTSD groups reported greater motivation to smoke to reduce negative affect. Individuals with PTSD endorsed a stronger expectation that smoking would alleviate negative mood states and would produce negative consequences. Overall, results suggest that smokers with PD or PTSD differ from other smoking groups in a number of clinically significant ways. Keywords Smoking; Panic; PTSD; Anxiety Disorders; Smoking Motives and ExpectanciesCorrespondence concerning this article should be addressed to Michael J. Zvolensky, Ph.D. at The University of Vermont, Department of Psychology, 2 Colchester Avenue, John Dewey Hall, Burlington,. Electronic mail may be sent to Michael.Zvolensky@uvm.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. There is an increasing empirical recognition that tobacco use and dependence are elevated among those with psychopathology compared to those without psychiatric conditions (Kalman, Morissette, & George, 2005). For example, persons with, relative to those without, psychiatric disorders are approximately twice as likely to be current smokers (Lasser et al., 2000). Moreover, it is estimated that although smokers with psychiatric disorders represent approximately 20% of persons in the United States (U.S.), they consume over 40% of the cigarettes in the nation (Lasser et al., 2000). Such high rates of smoking among those with psychiatric disorders may play a clinically significant role in the high rates of diagnostic comorbidity and mortality observed in people with psychiatric disorders (Kalman et al., 2005). NIH Public AccessRecent studies have found important linkages between smoking and certain anxiety disorders (Feldner, Babson, & Zvolensky, 2007a;Morissette, Tull, Gulliver, Kamholz, & Zimering, 2007;Patton, Carlin, Coffey, Wolfe, Hibbert, & Bowes, 1998; Zvolensky, Feldner, LeenFeldner, & McLeish, 2005 (Beckham et al., 1995;Breslau et al., 2003;Buckley et al., 2004;Feldner et al., 2007a). Recent contr...

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Section: Discussionmentioning

confidence: 71%

Section: Nih Public Accessmentioning

confidence: 99%

“…Recent studies have found important linkages between smoking and certain anxiety disorders (Feldner, Babson, & Zvolensky, 2007a;Morissette, Tull, Gulliver, Kamholz, & Zimering, 2007;Patton, Carlin, Coffey, Wolfe, Hibbert, & Bowes, 1998;Zvolensky, Feldner, LeenFeldner, & McLeish, 2005). Some of the most robust, clinically-significant relations documented between smoking and anxiety conditions have been evident for panic psychopathology (panic attacks [PA], panic disorder [PD], and agoraphobia) and posttraumatic stress disorder (PTSD).…”

mentioning

confidence: 99%

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Evaluation of smoking characteristics among community-recruited daily smokers with and without posttraumatic stress disorder and panic psychopathology

Marshall¹,

Zvolensky²,

Vujanovic³

et al. 2008

Journal of Anxiety Disorders

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“…In the striatum, modulation of dopamine release by nAChRs may affect symptoms as well as the pathological degeneration of the dopaminergic neurons in Parkinson's disease [53]. Interest in nicotinic regulation of the dopamine system has also been stimulated by the observations that some of nicotine's effects on learning and memory [54,55], anxiety [56,57] and locomotor activation [58,59] may result as a consequence of dopamine release. Additional interest in nAChR-dopamine interactions comes from the observations that individuals suffering from dopamine-related psychopathologies such as schizophrenia and attention deficit hyperactivity are frequently smokers (incidence > 50-60%) [60,61] and that smoking may retard the onset of Parkinson's disease [62].…”

mentioning

confidence: 99%

The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum

Grady

Salminen

Laverty

et al. 2007

Biochemical Pharmacology

232

223

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This review summarizes studies that attempted to determine the subtypes of nicotinic acetylcholine receptors (nAChR) expressed in the dopaminergic nerve terminals in the mouse. A variety of experimental approaches has been necessary to reach current knowledge of these subtypes, including in situ hybridization, agonist and antagonist binding, function measured by neurotransmitter release from synaptosomal preparations, and immunoprecipitation by selective antibodies. Early developments that facilitated this effort include the radioactive labeling of selective binding agents, such as [ 125 I]-α-bungarotoxin and [ 3 H]-nicotine, advances in cloning the subunits, and expression and evaluation of function of combinations of subunits in Xenopus oocytes. The discovery of epibatidine and α-conotoxin MII (α-CtxMII), and the development of nAChR subunit null mutant mice have been invaluable in determining which nAChR subunits are important for expression and function in mice, as well as allowing validation of the specificity of subunit specific antibodies. These approaches have identified five nAChR subtypes of nAChR that are expressed on dopaminergic nerve terminals. Three of these contain the α6 subunit (α4α6β2β3, α6β2β3, α6β2) and bind α-CtxMII with high affinity. One of these three subtypes (α4α6β2β3) also has the highest sensitivity to nicotine of any native nAChR that has been studied, to date. The two subtypes that do not have high affinity for α-CtxMII (α4β2, α4α5β2) are somewhat more numerous than the α6* subtypes, but do bind nicotine with high affinity. Given that our first studies detected readily measured differences in sensitivity to agonists and antagonists among these five nAChR subtypes, it seems likely that subtype selective compounds could be developed that would allow therapeutic manipulation of diverse nAChRs that have been implicated in a number of human conditions. Alterations in nicotinic cholinergic receptor (nAChRs) number or function have been implicated in psychopathologies such as anxiety, attention deficit hyperactivity disorder, depression, schizophrenia (reviewed in [1,2,3]), at least one form of familial epilepsy [4], and Parkinson's and Alzheimer's diseases [5]. It is not particularly surprising that nAChRs might play important roles in modulating several human diseases given that binding sites for nicotinic ligands such as [ 125 I]-α-bungarotoxin [6,7,8], [ 3 H]-nicotine [7,8] Corresponding author: Sharon R Grady e-mail: sharon.grady@colorado.edu phone: 303-492-9677 fax: 303-492-8063 mailing address: Institute for Behavioral Genetics University of Colorado 447UCB Boulder, CO 80309. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered w...

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“…Level two of the model accounted for an additional 5% of the variance, with the appetite control subscale being the only significant predictor (β = −.16, p < .05). There is a recent and increasingly well-documented association between cigarette smoking and depressive and anxiety symptoms and disorders (Morrell & Cohen, 2006;Morissette, Tull, Gulliver, Kamholz, & Zimering, 2007;Patton, Carlin, Coffey, Wolfe, Hibbert, & Bowes, 1998). Indeed, epidemiological (Grant, Hasin, Chou, Stinson, & Dawson, 2004;Lasser, et al, 2000), community (Hayward, Killen, & Taylor, 1989) and clinical (Himle, Thyer, & Fischer, 1988;McCabe et al, 2004;Pohl, Yeragani, Balon, Lycaki, & McBride, 1992) studies have found that daily cigarette smoking is more common among those with anxiety and depressive psychopathology compared to those without such problems.…”

mentioning

confidence: 99%

Linkages between cigarette smoking outcome expectancies and negative emotional vulnerability

Johnson¹,

Zvolensky²,

Marshall³

et al. 2008

Addictive Behaviors

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The present investigation examined whether smoking outcome expectancies, as measured by the Smoking Consequences Questionnaire (SCQ; Brandon & Baker, 1991), were incrementally related to emotional vulnerability factors among an adult sample of 202 daily cigarette smokers (44.6% women; M age = 23.78 years, SD = 9.69 years). After controlling for cigarettes smoked per day, past 30-day marijuana use, current alcohol consumption, and coping style, negative reinforcement/ negative affect reduction outcome expectancies were significantly associated with greater levels of negative affectivity, emotional dysregulation, and anxiety sensitivity. The observed effects for negative reinforcement/negative affect reduction also were independent of shared variance with other outcome expectancies. Negative personal consequences outcome expectancies were significantly and incrementally related to anxiety sensitivity, but not negative affectivity or emotional dysregulation. Findings are discussed in terms of the role of negative reinforcement/negative affect reduction smoking outcome expectancies and clinically-relevant negative emotional vulnerability for better understanding cigarette smoking-negative mood problems.Correspondence concerning this article should be addressed to Michael J. Zvolensky, Ph.D., Dr. Zvolensky can be contacted at The University of Vermont, Department of Psychology, 2, Colchester Avenue, John Dewey Hall, Burlington,. Electronic mail may be sent to Michael.Zvolensky@uvm.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 2 Although not a primary aim of the current study, exploratory analyses focused on positive affectivity were completed for comparative purposes. These analyses were completed in an identical fashion to those reported in the paper except positive affectivity was employed as the dependent variable. Here, predictor variables accounted for 22.1% of the overall variance for positive affectivity [F(9, 198) = 5.95, p < .001]. Level one of the model accounted for 17.1% of the variance, with significant contributions by the emotional processing and emotional expression subscales (β = .30, p < .001 and β = .16, p < .05, respectively). Level two of the model accounted for an additional 5% of the variance, with the appetite control subscale being the only significant predictor (β = −.16, p < .05). There is a recent and increasingly well-documented association between cigarette smoking and depressive and anxiety symptoms and disorders (Morrell & Cohen, 2006;Morissette, Tull, Gulliver, Kamholz, & Zimering, 2007;Patton, Carlin, Coffey, Wolfe, Hibbert, & ...

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Anxiety, anxiety disorders, tobacco use, and nicotine: A critical review of interrelationships.

Cited by 335 publications

References 330 publications

Evaluation of smoking characteristics among community-recruited daily smokers with and without posttraumatic stress disorder and panic psychopathology

Evaluation of smoking characteristics among community-recruited daily smokers with and without posttraumatic stress disorder and panic psychopathology

The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum

Linkages between cigarette smoking outcome expectancies and negative emotional vulnerability

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